insertion into alkane sp
3 C–H bond with EDA in quantitative yield. More importantly, those silver complexes could be separated and reused several times without
loss of efficacy and chemo- and regioselectivities under a fluorous phase (Fomblin
or perfluorophenanthrene). For example, by using 2,3-dimethylbutane (1 mL,
7.6 mmol) as the substrate, silver complex 7 (0.005 mmol) F 51 -Tp
4Bo,3(CF2)
5CF3 Ag(acetone) as the catalyst, ethyl diazoacetate (10.5 μL, 0.1 mmol) as a carbene
Scheme 3 Silver complex-catalyzed carbene insertion into sp
3 C–H bonds
Silver-Mediated Direct sp
3 C–H Bond Functionalization
119
3 C–H bond with EDA in quantitative yield. More importantly, those silver complexes could be separated and reused several times without
loss of efficacy and chemo- and regioselectivities under a fluorous phase (Fomblin
or perfluorophenanthrene). For example, by using 2,3-dimethylbutane (1 mL,
7.6 mmol) as the substrate, silver complex 7 (0.005 mmol) F 51 -Tp
4Bo,3(CF2)
5CF3 Ag(acetone) as the catalyst, ethyl diazoacetate (10.5 μL, 0.1 mmol) as a carbene
Scheme 3 Silver complex-catalyzed carbene insertion into sp
3 C–H bonds
Silver-Mediated Direct sp
3 C–H Bond Functionalization
119