4 DNA Dependent DNA Polymerases as Targets for Low-Weight …
131
72. Togashi H, Mizushina Y, Takemura M, Sugawara F, Koshino H, Esumi Y, Uzawa J, Kumagai
H, Matsukage A, Yoshida S, Sakaguchi K (1998) 4-Hydroxy-17-methylincisterol, an inhibitor
of DNA polymerase-α activity and the growth of human cancer cells in vitro. Biochem Pharmacol 56(5):583–590
73. Cao S, Gao Z, Thomas SJ, Hecht SM, Lazo JS, Kingston DG (2004) Marine sesquiterpenoids
that inhibit the lyase activity of DNA polymerase β. J Nat Prod 67:1716–1718
74. Mizushina Y, Ishidoh T, Kamisuki S, Nakazawa S, Takemura M, Sugawara F, Yoshida H,
Sakaguchi K (2003) Flavonoid glycoside: a new inhibitor of eukaryotic DNA polymerase alpha and a new carrier for inhibitor-affinity chromatography. Biochem Biophys Res Commun
301(2):480–487
75. Ogawa A, Murate T, Izuta S, Takemura M, Furuta K, Kobayashi J, Kamikawa T, Nimura Y,
Yoshida S (1998) Sulfated glycoglycerolipid from archaebacterium inhibits eukaryotic DNA
polymerase α, β and retroviral reverse transcriptase and affects methylmethanesulfonate cytotoxicity
76. Mizushina Y, Manita D, Takeuchi T, Sugawara F, Kumamoto-Yonezawa Y, Matsui Y, Takemura M, Sasaki M, Yoshida H, Takikawa H (2009) The inhibitory action of kohamaic acid A
derivatives on mammalian DNA polymerase β. Molecules 14(1):102–121
77. Sun DA, Starck SR, Locke EP, Hecht SM (1999) DNA polymerase beta inhibitors from Sandoricum koetjape. J Nat Prod 62: 1110–1113
78. Hu HY, Horton JK, Gryk MR, Prasad R, Naron JM, Sun DA, Hecht SM, Wilson SH, Mullen GP (2004) Identification of small molecule synthetic inhibitors of DNA polymerase β by
NMR chemical shift mapping. J Biol Chem 279:39736–39744
79. Mizushina Y, Tanaka N, Yagi H, Kurosawa T, Onoue M, Seto H, Horie T, Aoyagi N, Yamaoka
M, Matsukage A, Yoshida S, Sakaguchi K (1996) Fatty acids selectively inhibit eukaryotic
DNA polymerase activities in vitro. Biochim Biophys Acta 1308(3):256–262
80. Mizushina Y, Yoshida S, Matsukage A, Sakaguchi K (1997) The inhibitory action of fatty
acids on DNA polymerase β. Biochim Biophys Acta 1336(3):509–521
81. Mizushina Y, Watanabe I, Ohta K, Takemura M, Sahara H, Takahashi N, Gasa S, Sugawara F,
Matsukage A, Yoshida S, Sakaguchi K (1998) Studies on inhibitors of mammalian DNA polymerase α and β: sulfolipids from a pteridophyte, Athyrium niponicum. Biochem Pharmacol
55(4):537–541
82. Mizushina Y, Ohkubo T, Sugawara F, Sakaguchi K. (2000) Structure of lithocholic acid
binding to the N-terminal 8-kDa domain of DNA polymerase β. Biochemistry 39(41):
12606–12613
83. Ogawa A, Murate T, Suzuki M, Nimura Y, Yoshida S (1998) Lithocholic acid, a putative tumor
promoter, inhibits mammalian DNA polymerase β. Jpn J Cancer Res 89(11):1154–1159
84. Chaturvedula VS, Gao Z, Jones SH, Feng X, Hecht SM, Kingston DG (2004) A new ursane
tri-terpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase. J Nat Prod
67:899–901
85. Mizushina Y, Ishidoh T, Takeuchi T, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S,
Sugawara F, Sakaguchi K, Yoshida H (2005) Monoacetylcurcumin: a new inhibitor of eukaryotic DNA polymerase λ and a new ligand for inhibitor-affinity chromatography. Biochem
Biophys Res Commun 337(4):1288–1295
86. Takeuchi T, Ishidoh T, Iijima H, Kuriyama I, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y (2006) Structural relationship
of curcumin derivatives binding to the BRCT domain of human DNA polymerase λ. Genes
Cells 11(3):223–235
87. Maloney DJ, Deng JZ, Starck SR, Gao Z, Hecht SM (2005) (ı)-Myristinin A, a naturally
occurring DNA polymerase β inhibitor and potent DNA-damaging agent. J Am Chem Soc
127(12): 4140–4141
88. Shiomi K, Kuriyama I, Yoshida H, Mizushina Y (2013) Inhibitory effects of myricetin on
mammalian DNA polymerase, topoisomerase and human cancer cell proliferation. Food
Chem 139(1–4):910–918
131
72. Togashi H, Mizushina Y, Takemura M, Sugawara F, Koshino H, Esumi Y, Uzawa J, Kumagai
H, Matsukage A, Yoshida S, Sakaguchi K (1998) 4-Hydroxy-17-methylincisterol, an inhibitor
of DNA polymerase-α activity and the growth of human cancer cells in vitro. Biochem Pharmacol 56(5):583–590
73. Cao S, Gao Z, Thomas SJ, Hecht SM, Lazo JS, Kingston DG (2004) Marine sesquiterpenoids
that inhibit the lyase activity of DNA polymerase β. J Nat Prod 67:1716–1718
74. Mizushina Y, Ishidoh T, Kamisuki S, Nakazawa S, Takemura M, Sugawara F, Yoshida H,
Sakaguchi K (2003) Flavonoid glycoside: a new inhibitor of eukaryotic DNA polymerase alpha and a new carrier for inhibitor-affinity chromatography. Biochem Biophys Res Commun
301(2):480–487
75. Ogawa A, Murate T, Izuta S, Takemura M, Furuta K, Kobayashi J, Kamikawa T, Nimura Y,
Yoshida S (1998) Sulfated glycoglycerolipid from archaebacterium inhibits eukaryotic DNA
polymerase α, β and retroviral reverse transcriptase and affects methylmethanesulfonate cytotoxicity
76. Mizushina Y, Manita D, Takeuchi T, Sugawara F, Kumamoto-Yonezawa Y, Matsui Y, Takemura M, Sasaki M, Yoshida H, Takikawa H (2009) The inhibitory action of kohamaic acid A
derivatives on mammalian DNA polymerase β. Molecules 14(1):102–121
77. Sun DA, Starck SR, Locke EP, Hecht SM (1999) DNA polymerase beta inhibitors from Sandoricum koetjape. J Nat Prod 62: 1110–1113
78. Hu HY, Horton JK, Gryk MR, Prasad R, Naron JM, Sun DA, Hecht SM, Wilson SH, Mullen GP (2004) Identification of small molecule synthetic inhibitors of DNA polymerase β by
NMR chemical shift mapping. J Biol Chem 279:39736–39744
79. Mizushina Y, Tanaka N, Yagi H, Kurosawa T, Onoue M, Seto H, Horie T, Aoyagi N, Yamaoka
M, Matsukage A, Yoshida S, Sakaguchi K (1996) Fatty acids selectively inhibit eukaryotic
DNA polymerase activities in vitro. Biochim Biophys Acta 1308(3):256–262
80. Mizushina Y, Yoshida S, Matsukage A, Sakaguchi K (1997) The inhibitory action of fatty
acids on DNA polymerase β. Biochim Biophys Acta 1336(3):509–521
81. Mizushina Y, Watanabe I, Ohta K, Takemura M, Sahara H, Takahashi N, Gasa S, Sugawara F,
Matsukage A, Yoshida S, Sakaguchi K (1998) Studies on inhibitors of mammalian DNA polymerase α and β: sulfolipids from a pteridophyte, Athyrium niponicum. Biochem Pharmacol
55(4):537–541
82. Mizushina Y, Ohkubo T, Sugawara F, Sakaguchi K. (2000) Structure of lithocholic acid
binding to the N-terminal 8-kDa domain of DNA polymerase β. Biochemistry 39(41):
12606–12613
83. Ogawa A, Murate T, Suzuki M, Nimura Y, Yoshida S (1998) Lithocholic acid, a putative tumor
promoter, inhibits mammalian DNA polymerase β. Jpn J Cancer Res 89(11):1154–1159
84. Chaturvedula VS, Gao Z, Jones SH, Feng X, Hecht SM, Kingston DG (2004) A new ursane
tri-terpene from Monochaetum vulcanicum that inhibits DNA polymerase β lyase. J Nat Prod
67:899–901
85. Mizushina Y, Ishidoh T, Takeuchi T, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S,
Sugawara F, Sakaguchi K, Yoshida H (2005) Monoacetylcurcumin: a new inhibitor of eukaryotic DNA polymerase λ and a new ligand for inhibitor-affinity chromatography. Biochem
Biophys Res Commun 337(4):1288–1295
86. Takeuchi T, Ishidoh T, Iijima H, Kuriyama I, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y (2006) Structural relationship
of curcumin derivatives binding to the BRCT domain of human DNA polymerase λ. Genes
Cells 11(3):223–235
87. Maloney DJ, Deng JZ, Starck SR, Gao Z, Hecht SM (2005) (ı)-Myristinin A, a naturally
occurring DNA polymerase β inhibitor and potent DNA-damaging agent. J Am Chem Soc
127(12): 4140–4141
88. Shiomi K, Kuriyama I, Yoshida H, Mizushina Y (2013) Inhibitory effects of myricetin on
mammalian DNA polymerase, topoisomerase and human cancer cell proliferation. Food
Chem 139(1–4):910–918