130
51. Acosta EP, Fletcher CV (1997) Valacyclovir. Ann Pharmacother 31:185–191
52. Mizushina Y (2009) Specific inhibitors of mammalian DNA polymerase species. Biotechnol
Biochem 73(6):1239–1251
53. Barakat KH, Gajewski MM, Tuszynski JA (2012) DNA polymerase beta (pol β) inhibitors: a
comprehensive overview. Drug Discov Today 17(15–16):913–920
54. Chen J, Zhang YH, Wang LK, Sucheck SJ, Snow AM, Hecht SM (1998) Inhibitors of DNA
polymerase β from Schoepfia californica. J Chem Soc Chem Commun 24:2769–2770
55. Spadari S, Pedrali-Noy G, Falaschi MC, Ciarrocchi G (1984) Control of DNA replication and
cell proliferation in eukaryotes by aphidicolin. Toxicol Pathol 12(2):143–148
56. Arabshahi L, Brown N, Khan N, Wright G. (1988) Inhibition of DNApolymerase alpha by
aphidicolin derivatives. Nucleic Acids Res 16:5107–5113
57. Ma J, Starck SR, Hecht SM (1999) DNA polymerase β inhibitors from Tetracera boiviniana.
J Nat Prod 62:1660–1663
58. Deng JZ, Starck SR, Hecht SM (1999) Bis-5-alkylresorcinols from Panopsis rubescens that
inhibit DNA polymerase β. J Nat Prod 62:477–480
59. Mizushina Y, Matsukage A, Sakaguchi K (1998) The biochemical inhibition mode of bredinin-5’-monophosphate on DNA polymerase β. Biochim Biophys Acta 1403(1):5–11
60. Talanian RV, Brown NC, McKenna CE, Ye TG, Levy JN, Wright GE (1989) Carbonyldiphosphonate, a selective inhibitor of mammalian DNA polymerase δ. Biochemistry 28(21):
8270–8274
61. Oshige M, Takenouchi M, Kato Y, Kamisuki S, Takeuchi T, Kuramochi K, Shiina I, Suenaga
Y, Kawakita Y, Kuroda K, Sato N, Kobayashi S, Sugawara F, Sakaguchi K (2004) Taxol derivatives are selective inhibitors of DNA polymerase α. Bioorg Med Chem 12(10):2597–2601
62. Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd
RS (2012) A comprehensive strategy to discover inhibitors of the translesion synthesis DNA
polymerase κ. PLoS One 7(10): e45032
63. Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K,
Sugawara F, Yoshida H, Sato N, Mizushina Y (2007) Anti-tumor effects of dehydroaltenusin,
a specific inhibitor of mammalian DNA polymerase alpha. Biochem Biophys Res Commun
352(2):390–396
64. Mizushina Y, Xu X, Asano N, Kasai N, Kato A, Takemura M, Asahara H, Linn S, Sugawara
F, Yoshida H, Sakaguchi K (2003) The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-d-ribitol, on eukaryotic DNA polymerases. Biochem Biophys Res Commun
304:78–85
65. Li SS, Gao Z, Feng X, Hecht SM (2004) Biscoumarin derivatives from Edgeworthia gardneri
that inhibit the lyase activity of DNA polymerase β. J Nat Prod 67(9):1608–1610
66. Feng X, Gao Z, Li S, Jones SH, Hecht SM (2004) DNA polymerase β lyase inhibitors from
Maytenus putterlickoides. J Nat Prod 67:1744–1747
67. Mizushina Y, Watanabe I, Togashi H, Hanashima L, Takemura M, Ohta K, Sugawara F, Koshino H, Esumi Y, Uzawa J, Matsukage A, Yoshida S, Sakaguchi K (1998) An ergosterol
peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on
DNA polymerase β. Biol Pharm Bull 21(5):444–448
68. Mizushina Y, Tanaka N, Kitamura A, Tamai K, Ikeda M, Takemura M, Sugawara F, Arai T,
Matsukage A, Yoshida S, Sakaguchi K (1998) The inhibitory effect of novel triterpenoid compounds, fomitellic acids, on DNA polymerase beta. Biochem J 330(Pt 3):1325–1332
69. Tanaka N, Kitamura A, Mizushina Y, Sugawara F, Sakaguchi K (1998) Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea.
J Nat Prod 61(2):193–197
70. Ishida T, Mizushina Y, Yagi S, Irino Y, Nishiumi S, Miki I, Kondo Y, Mizuno S, Yoshida H,
Azuma T, Yoshida M (2012) Inhibitory effects of glycyrrhetinic acid on DNA polymerase and
inflammatory activities. Evid Based Complement Alternat Med 2012:650514
71. Deng JZ, Starck SR, Hecht SM, Ijames CF, Hemling ME (1999) Harbinatic acid, a novel and
potent DNA polymerase β inhibitor from Hardwickia binata. J Nat Prod 62:1000–1002
A. Yu. Nyporko
51. Acosta EP, Fletcher CV (1997) Valacyclovir. Ann Pharmacother 31:185–191
52. Mizushina Y (2009) Specific inhibitors of mammalian DNA polymerase species. Biotechnol
Biochem 73(6):1239–1251
53. Barakat KH, Gajewski MM, Tuszynski JA (2012) DNA polymerase beta (pol β) inhibitors: a
comprehensive overview. Drug Discov Today 17(15–16):913–920
54. Chen J, Zhang YH, Wang LK, Sucheck SJ, Snow AM, Hecht SM (1998) Inhibitors of DNA
polymerase β from Schoepfia californica. J Chem Soc Chem Commun 24:2769–2770
55. Spadari S, Pedrali-Noy G, Falaschi MC, Ciarrocchi G (1984) Control of DNA replication and
cell proliferation in eukaryotes by aphidicolin. Toxicol Pathol 12(2):143–148
56. Arabshahi L, Brown N, Khan N, Wright G. (1988) Inhibition of DNApolymerase alpha by
aphidicolin derivatives. Nucleic Acids Res 16:5107–5113
57. Ma J, Starck SR, Hecht SM (1999) DNA polymerase β inhibitors from Tetracera boiviniana.
J Nat Prod 62:1660–1663
58. Deng JZ, Starck SR, Hecht SM (1999) Bis-5-alkylresorcinols from Panopsis rubescens that
inhibit DNA polymerase β. J Nat Prod 62:477–480
59. Mizushina Y, Matsukage A, Sakaguchi K (1998) The biochemical inhibition mode of bredinin-5’-monophosphate on DNA polymerase β. Biochim Biophys Acta 1403(1):5–11
60. Talanian RV, Brown NC, McKenna CE, Ye TG, Levy JN, Wright GE (1989) Carbonyldiphosphonate, a selective inhibitor of mammalian DNA polymerase δ. Biochemistry 28(21):
8270–8274
61. Oshige M, Takenouchi M, Kato Y, Kamisuki S, Takeuchi T, Kuramochi K, Shiina I, Suenaga
Y, Kawakita Y, Kuroda K, Sato N, Kobayashi S, Sugawara F, Sakaguchi K (2004) Taxol derivatives are selective inhibitors of DNA polymerase α. Bioorg Med Chem 12(10):2597–2601
62. Yamanaka K, Dorjsuren D, Eoff RL, Egli M, Maloney DJ, Jadhav A, Simeonov A, Lloyd
RS (2012) A comprehensive strategy to discover inhibitors of the translesion synthesis DNA
polymerase κ. PLoS One 7(10): e45032
63. Maeda N, Kokai Y, Ohtani S, Sahara H, Kuriyama I, Kamisuki S, Takahashi S, Sakaguchi K,
Sugawara F, Yoshida H, Sato N, Mizushina Y (2007) Anti-tumor effects of dehydroaltenusin,
a specific inhibitor of mammalian DNA polymerase alpha. Biochem Biophys Res Commun
352(2):390–396
64. Mizushina Y, Xu X, Asano N, Kasai N, Kato A, Takemura M, Asahara H, Linn S, Sugawara
F, Yoshida H, Sakaguchi K (2003) The inhibitory action of pyrrolidine alkaloid, 1,4-dideoxy-1,4-imino-d-ribitol, on eukaryotic DNA polymerases. Biochem Biophys Res Commun
304:78–85
65. Li SS, Gao Z, Feng X, Hecht SM (2004) Biscoumarin derivatives from Edgeworthia gardneri
that inhibit the lyase activity of DNA polymerase β. J Nat Prod 67(9):1608–1610
66. Feng X, Gao Z, Li S, Jones SH, Hecht SM (2004) DNA polymerase β lyase inhibitors from
Maytenus putterlickoides. J Nat Prod 67:1744–1747
67. Mizushina Y, Watanabe I, Togashi H, Hanashima L, Takemura M, Ohta K, Sugawara F, Koshino H, Esumi Y, Uzawa J, Matsukage A, Yoshida S, Sakaguchi K (1998) An ergosterol
peroxide, a natural product that selectively enhances the inhibitory effect of linoleic acid on
DNA polymerase β. Biol Pharm Bull 21(5):444–448
68. Mizushina Y, Tanaka N, Kitamura A, Tamai K, Ikeda M, Takemura M, Sugawara F, Arai T,
Matsukage A, Yoshida S, Sakaguchi K (1998) The inhibitory effect of novel triterpenoid compounds, fomitellic acids, on DNA polymerase beta. Biochem J 330(Pt 3):1325–1332
69. Tanaka N, Kitamura A, Mizushina Y, Sugawara F, Sakaguchi K (1998) Fomitellic acids, triterpenoid inhibitors of eukaryotic DNA polymerases from a basidiomycete, Fomitella fraxinea.
J Nat Prod 61(2):193–197
70. Ishida T, Mizushina Y, Yagi S, Irino Y, Nishiumi S, Miki I, Kondo Y, Mizuno S, Yoshida H,
Azuma T, Yoshida M (2012) Inhibitory effects of glycyrrhetinic acid on DNA polymerase and
inflammatory activities. Evid Based Complement Alternat Med 2012:650514
71. Deng JZ, Starck SR, Hecht SM, Ijames CF, Hemling ME (1999) Harbinatic acid, a novel and
potent DNA polymerase β inhibitor from Hardwickia binata. J Nat Prod 62:1000–1002
A. Yu. Nyporko