132
89. Prakash Chaturvedula VS, Hecht SM, Gao Z, Jones SH, Feng X, Kingston DG (2004) New
neolignans that inhibit DNA polymerase beta lyase. J Nat Prod 67(6): 964–967
90. Deng JZ, Starck SR, Hecht SM (2000) Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase β. Bioorg Med Chem 8:247–250
91. Brideau RJ, Knechtel ML, Huang A, Vaillancourt VA, Vera EE, Oien NL, Hopkins TA,
Wieber JL, Wilkinson KF, Rush BD, Schwende FJ, Wathen MW (2002) Broad-spectrum
antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses. Antiviral Res 54(1):19–28
92. Oien NL, Brideau RJ, Hopkins TA, Wieber JL, Knechtel ML, Shelly JA, Anstadt RA, Wells
PA, Poorman RA, Huang A, Vaillancourt VA, Clayton TL, Tucker JA, Wathen MW (2002)
Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of
herpesvirus polymerase inhibitors. Antimicrob Agents Chemother 46(3):724–730
93. Hazan C, Boudsocq F, Gervais V, Saurel O, Ciais M, Cazaux C, Czaplicki J, Milon A (2008)
Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase β complex:
towards the design of higher-affinity inhibitors. BMC Struct Biol 8:22
94. Mizushina Y, Zhang J, Pugliese A, Kim SH, Lü J (2010) Anti-cancer gallotannin pentaO-galloyl-beta-d-glucose is a nanomolar inhibitor of select mammalian DNA polymerases.
Biochem Pharmacol 80(8):1125–1132
95. Mizushina Y, Kamisuki S, Kasai N, Ishidoh T, Shimazaki N, Takemura M, Asahara H, Linn
S, Yoshida S, Koiwai O, Sugawara F, Yoshida H, Sakaguchi K (2002) Petasiphenol: a DNA
polymerase λ inhibitor. Biochemistry 41(49):14463–14471
96. Mizushina Y, Xu X, Matsubara K, Murakami C, Kuriyama I, Oshige M, Takemura M, Kato
N, Yoshida H, Sakaguchi K (2003) Pyridoxal 5’-phosphate is a selective inhibitor in vivo of
DNA polymerase α and e. Biochem Biophys Res Commun 312(4):1025–1032
97. Locatelli GA, Savio M, Forti L, Shevelev I, Ramadan K, Stivala LA, Vannini V, Hübscher
U, Spadari S, Maga G (2005) Inhibition of mammalian DNA polymerases by resveratrol:
mechanism and structural determinants. Biochem J 389(Pt 2): 259–268
98. Strittmatter T, Bareth B, Immel TA, Huhn T, Mayer TU, Marx A (2011) Small molecule
inhibitors of human DNA polymerase λ. ACS Chem Biol 6(4):314–319
99. Ishimaru C, Yonezawa Y, Kuriyama I, Nishida M, Yoshida H, Mizushina Y (2008) Inhibitory
effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth. Lipids 43(4):373–382
100. Perpelescu M, Kobayashi J, Furuta M, Ito Y, Izuta S, Takemura M, Suzuki M, Yoshida S
(2002) Novel phenalenone derivatives from a marine-derived fungus exhibit distinct inhibition spectra against eukaryotic DNA polymerases. Biochemistry 41:7610–7616
101. Mizushina Y, Nakanishi R, Kuriyama I, Kamiya K, Satake T, Shimazaki N, Koiwai O,
Uchiya-ma Y, Yonezawa Y, Takemura M, Sakaguchi K, Yoshida H (2006) Beta-sitosterol3-O-beta-d-glucopyranoside: a eukaryotic DNA polymerase λ inhibitor. J Steroid Biochem
Mol Biol 99(2–3):100–107
102. Mizushina Y, Kasai N, Iijima H, Sugawara F, Yoshida H, Sakaguchi K (2005) Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent.
Curr Med Chem Anticancer Agents 5(6):613–625
103. Mizushina, Y. et al. (2002) A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda. J. Biol. Chem 277:630–638
104. Kasai N, Mizushina Y, Murata H, Yamazaki T, Ohkubo T, Sakaguchi K, Sugawara F (2005)
Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase β.
FEBS J 272(17):4349–4361
105. Mizushina Y, Nakagawa K, Shibata A, Awata Y, Kuriyama I, Shimazaki N, Koiwai O,
Uchiyama Y, Sakaguchi K, Miyazawa T, Yoshida H (2006) Inhibitory effect of tocotrienol
on eukaryotic DNA polymerase λ and angiogenesis. Biochem Biophys Res Commun 339(3):
949–955
106. Deng JZ, Starck SR, Hecht SM (1999) DNA polymerase β inhibitors from Baeckea gunniana.
J Nat Prod 62:1624–1626
A. Yu. Nyporko
89. Prakash Chaturvedula VS, Hecht SM, Gao Z, Jones SH, Feng X, Kingston DG (2004) New
neolignans that inhibit DNA polymerase beta lyase. J Nat Prod 67(6): 964–967
90. Deng JZ, Starck SR, Hecht SM (2000) Pentacyclic triterpenoids from Freziera sp. that inhibit DNA polymerase β. Bioorg Med Chem 8:247–250
91. Brideau RJ, Knechtel ML, Huang A, Vaillancourt VA, Vera EE, Oien NL, Hopkins TA,
Wieber JL, Wilkinson KF, Rush BD, Schwende FJ, Wathen MW (2002) Broad-spectrum
antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses. Antiviral Res 54(1):19–28
92. Oien NL, Brideau RJ, Hopkins TA, Wieber JL, Knechtel ML, Shelly JA, Anstadt RA, Wells
PA, Poorman RA, Huang A, Vaillancourt VA, Clayton TL, Tucker JA, Wathen MW (2002)
Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of
herpesvirus polymerase inhibitors. Antimicrob Agents Chemother 46(3):724–730
93. Hazan C, Boudsocq F, Gervais V, Saurel O, Ciais M, Cazaux C, Czaplicki J, Milon A (2008)
Structural insights on the pamoic acid and the 8 kDa domain of DNA polymerase β complex:
towards the design of higher-affinity inhibitors. BMC Struct Biol 8:22
94. Mizushina Y, Zhang J, Pugliese A, Kim SH, Lü J (2010) Anti-cancer gallotannin pentaO-galloyl-beta-d-glucose is a nanomolar inhibitor of select mammalian DNA polymerases.
Biochem Pharmacol 80(8):1125–1132
95. Mizushina Y, Kamisuki S, Kasai N, Ishidoh T, Shimazaki N, Takemura M, Asahara H, Linn
S, Yoshida S, Koiwai O, Sugawara F, Yoshida H, Sakaguchi K (2002) Petasiphenol: a DNA
polymerase λ inhibitor. Biochemistry 41(49):14463–14471
96. Mizushina Y, Xu X, Matsubara K, Murakami C, Kuriyama I, Oshige M, Takemura M, Kato
N, Yoshida H, Sakaguchi K (2003) Pyridoxal 5’-phosphate is a selective inhibitor in vivo of
DNA polymerase α and e. Biochem Biophys Res Commun 312(4):1025–1032
97. Locatelli GA, Savio M, Forti L, Shevelev I, Ramadan K, Stivala LA, Vannini V, Hübscher
U, Spadari S, Maga G (2005) Inhibition of mammalian DNA polymerases by resveratrol:
mechanism and structural determinants. Biochem J 389(Pt 2): 259–268
98. Strittmatter T, Bareth B, Immel TA, Huhn T, Mayer TU, Marx A (2011) Small molecule
inhibitors of human DNA polymerase λ. ACS Chem Biol 6(4):314–319
99. Ishimaru C, Yonezawa Y, Kuriyama I, Nishida M, Yoshida H, Mizushina Y (2008) Inhibitory
effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth. Lipids 43(4):373–382
100. Perpelescu M, Kobayashi J, Furuta M, Ito Y, Izuta S, Takemura M, Suzuki M, Yoshida S
(2002) Novel phenalenone derivatives from a marine-derived fungus exhibit distinct inhibition spectra against eukaryotic DNA polymerases. Biochemistry 41:7610–7616
101. Mizushina Y, Nakanishi R, Kuriyama I, Kamiya K, Satake T, Shimazaki N, Koiwai O,
Uchiya-ma Y, Yonezawa Y, Takemura M, Sakaguchi K, Yoshida H (2006) Beta-sitosterol3-O-beta-d-glucopyranoside: a eukaryotic DNA polymerase λ inhibitor. J Steroid Biochem
Mol Biol 99(2–3):100–107
102. Mizushina Y, Kasai N, Iijima H, Sugawara F, Yoshida H, Sakaguchi K (2005) Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent.
Curr Med Chem Anticancer Agents 5(6):613–625
103. Mizushina, Y. et al. (2002) A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase beta and lambda. J. Biol. Chem 277:630–638
104. Kasai N, Mizushina Y, Murata H, Yamazaki T, Ohkubo T, Sakaguchi K, Sugawara F (2005)
Sulfoquinovosylmonoacylglycerol inhibitory mode analysis of rat DNA polymerase β.
FEBS J 272(17):4349–4361
105. Mizushina Y, Nakagawa K, Shibata A, Awata Y, Kuriyama I, Shimazaki N, Koiwai O,
Uchiyama Y, Sakaguchi K, Miyazawa T, Yoshida H (2006) Inhibitory effect of tocotrienol
on eukaryotic DNA polymerase λ and angiogenesis. Biochem Biophys Res Commun 339(3):
949–955
106. Deng JZ, Starck SR, Hecht SM (1999) DNA polymerase β inhibitors from Baeckea gunniana.
J Nat Prod 62:1624–1626
A. Yu. Nyporko