7 Quantitative Analysis of Retinal Layers’ Optical Intensities …
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7.5.4 Results
Due to the difficulty to enroll exactly age-matched normal controls, the CRAO subjects were slightly older compared to the control group (77.0 ± 5.7 vs 71.9 ± 4.5 years
old, p < 0.001). There was no statistically significant difference of gender distribution or perceived quality of included images between the CRAO and control groups.
No statistically significant correlation was found between the optical intensities of
retinal layers and the disease duration from the onset to the image acquisition (all p
> 0.05).
The mean and standard deviation of optical intensities and optical intensity ratios
in each layer are shown in Table 7.4. Results of multilinear regression after adjusting
for optical intensity of the entire region and age are given in Table 7.4 and Fig. 7.9.
There was no statistically significant difference of optical intensities between the
CRAO and control subjects in the vitreous and RNFL (standardized beta 0.160 and
0.050 respectively, both p > 0.5). Optical intensities in GCL, IPL, INL and OPL were
higher in CRAO compared to controls (standardized beta 0.657, 0.702, 0.777 and
0.694, respectively, all p < 0.001). Optical intensity at ONL+HFL was not different
between the CRAO and control groups (standardized beta 0.047, p > 0.5). Optical
intensities at the photoreceptor, RPE, and choroidal layers were lower in the CRAO
cases compared to controls (standardized beta −0.412, −0.611 and −0.559, all
p < 0.001). Discriminant analysis found that the optical intensity of INL was most
strongly associated with the CRAO disease status (Wilks’ Lambda 0.641).
7.5.5 Discussion
The optical intensities in each segmented retinal layer detected from 3D-OCT for
CRAO patients and normal controls have been quantitatively investigated in this
study. The results showed that the optical intensities of vitreous, RNFL and ONL
were not different between CRAO and controls. The optical intensities of layers in
the inner retina, from GCL to OPL, were higher in CRAO than in controls, with the
most prominent increase identified at the INL. While the optical intensities from the
photoreceptor to choroidal layers were lower in CRAO patients than in controls, the
photoreceptor layer exhibited the most pronounced OCT image intensity decrease.
185
7.5.4 Results
Due to the difficulty to enroll exactly age-matched normal controls, the CRAO subjects were slightly older compared to the control group (77.0 ± 5.7 vs 71.9 ± 4.5 years
old, p < 0.001). There was no statistically significant difference of gender distribution or perceived quality of included images between the CRAO and control groups.
No statistically significant correlation was found between the optical intensities of
retinal layers and the disease duration from the onset to the image acquisition (all p
> 0.05).
The mean and standard deviation of optical intensities and optical intensity ratios
in each layer are shown in Table 7.4. Results of multilinear regression after adjusting
for optical intensity of the entire region and age are given in Table 7.4 and Fig. 7.9.
There was no statistically significant difference of optical intensities between the
CRAO and control subjects in the vitreous and RNFL (standardized beta 0.160 and
0.050 respectively, both p > 0.5). Optical intensities in GCL, IPL, INL and OPL were
higher in CRAO compared to controls (standardized beta 0.657, 0.702, 0.777 and
0.694, respectively, all p < 0.001). Optical intensity at ONL+HFL was not different
between the CRAO and control groups (standardized beta 0.047, p > 0.5). Optical
intensities at the photoreceptor, RPE, and choroidal layers were lower in the CRAO
cases compared to controls (standardized beta −0.412, −0.611 and −0.559, all
p < 0.001). Discriminant analysis found that the optical intensity of INL was most
strongly associated with the CRAO disease status (Wilks’ Lambda 0.641).
7.5.5 Discussion
The optical intensities in each segmented retinal layer detected from 3D-OCT for
CRAO patients and normal controls have been quantitatively investigated in this
study. The results showed that the optical intensities of vitreous, RNFL and ONL
were not different between CRAO and controls. The optical intensities of layers in
the inner retina, from GCL to OPL, were higher in CRAO than in controls, with the
most prominent increase identified at the INL. While the optical intensities from the
photoreceptor to choroidal layers were lower in CRAO patients than in controls, the
photoreceptor layer exhibited the most pronounced OCT image intensity decrease.