125
Barros AA, Silva JM, Craveiro R, Paiva A, Reis RL, Duarte ARC (2017) Green solvents for
enhanced impregnation processes in biomedicine. Curr Opin Green Sustain Chem 5:82–87.
https://doi.org/10.1016/j.cogsc.2017.03.014
Bellafiore IJ (1953) Stabilization of capsules of eutectic mixtures against liquefaction. J Am Pharm
Assoc 14:580–582. https://doi.org/10.1016/S0095-9561(16)33172-3
Blasco J, DelValls A (2008) Impact of emergent contaminants in the environment: environmental
risk assessment. Hdb Env Chem 5(S/1):169–188. https://doi.org/10.1007/698_5_107
Brennecke JF, Maginn EJ (2001) Ionic liquids: innovative fluids for chemical processing. AICHE
J 47:2384–2389. https://doi.org/10.1002/aic.690471102
Bubalo MC, Vidović S, Redovniković IR, Jokić S (2015) Green solvents for green technologies. J
Chem Technol Biotechnol 90:1631–1639. https://doi.org/10.1002/jctb.4668
Buckley MM, Benfield P (1993) Eutectic lidocaine/prilocaine cream: a review of the topical
anaesthetic/analgesic efficacy of a eutectic mixture of local anaesthetics (EMLA). Drugs
46:126–151. https://doi.org/10.2165/00003495-199346010-00008
Chavda HP, Patel CN, Anand IS (2010) Biopharmaceutics classification system. Sys Rev Pharm
(1):62–69
Cherukuvada S (2016) On the issues of resolving a low melting combination as a definite eutectic
or an elusive cocrystal: a critical evaluation. J Chem Sci 128:487–499. https://doi.org/10.1007/
s12039-016-1055-7
Cherukuvada S, Nangia A (2014) Eutectics as improved pharmaceutical materials: design, properties and characterization. Chem Commun 50:906–923. https://doi.org/10.1039/c3cc47521b
Choi YH, Spronsen JV, Dai Y, Verberne M, Hollmann F, Arends IWCE, Witkamp GJ, Verpoorte R
(2011) Are natural deep eutectic solvents the missing link in understanding cellular metabolism
and physiology? Plant Physiol 156:1701–1705. https://doi.org/10.1104/pp.111.178426
Cizmas L, Sharma VK, Gray CM, McDonald TJ (2015) Pharmaceuticals and personal care products in waters: occurrence, toxicity, and risk. Environ Chem Lett 13:381–394. https://doi.
org/10.1007/s10311-015-0524-4
Craveiro R, Aroso I, Flammia V, Carvalho T, Viciosa MT, Dionísio M, Barreiros S, Reis RL,
Duarte ARC, Paiva A (2016) Properties and thermal behavior of natural deep eutectic solvents.
J Mol Liq 215:534–540. https://doi.org/10.1016/j.molliq.2016.01.038
Dai Y, Spronsen JV, Witkamp GJ, Verpoorte R, Choi YH (2013) Natural deep eutectic solvents as new potential media for green technology. Anal Chim Acta 766:61–68. https://doi.
org/10.1016/j.aca.2012.12.019
Dai Y, Witkamp GJ, Verpoorte R, Choi YH (2015) Tailoring properties of natural deep eutectic solvents with water to facilitate their applications. Food Chem 187:14–19. https://doi.
org/10.1016/j.foodchem.2015.03.123
Dias AR, Costa-Rodrigues J, Fernandes MH, Ferraz R, Prudêncio C (2017) The anticancer potential of ionic liquids. Chem Med Chem 12:11–18. https://doi.org/10.1002/cmdc.201600480
Dichi E, Sghaier M, Guiblin N (2018) Reinvestigation of the paracetamol-caffeine, aspirin-caffeine
and paracetamol-aspirin phase equilibria diagrams. J Therm Anal Calorim 131:2141–2155.
https://doi.org/10.1007/s10973-017-6855-6
Domingos S, André V, Quaresma S, Martins ICB, Piedade MFM, Duarte MT (2015) New forms
of old drugs: improving without changing. J Pharm Pharmacol 67:830–846. https://doi.
org/10.1111/jphp.12384
Domínguez de María P, Maugeri Z (2011) Ionic liquids in biotransformations: from proof-ofconcept to emerging deep-eutectic-solvents. Curr Opin Chem Biol 15:220–225. https://doi.
org/10.1016/j.cbpa.2010.11.008
Duarte ARC, Ferreira ASD, Barreiros S, Cabrita E, Reis RL, Paiva A (2017) A comparison
between pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: solubility and permeability studies. Eur J Pharm Biopharm 114:296–304. https://doi.org/10.1016/j.
ejpb.2017.02.003
Dunn PJ (2012) The importance of green chemistry in process research and development. Chem
Soc Rev 41:1452–1461. https://doi.org/10.1039/c1cs15041c
3 Therapeutic Deep Eutectic Systems for the Enhancement of Drug Bioavailability
Barros AA, Silva JM, Craveiro R, Paiva A, Reis RL, Duarte ARC (2017) Green solvents for
enhanced impregnation processes in biomedicine. Curr Opin Green Sustain Chem 5:82–87.
https://doi.org/10.1016/j.cogsc.2017.03.014
Bellafiore IJ (1953) Stabilization of capsules of eutectic mixtures against liquefaction. J Am Pharm
Assoc 14:580–582. https://doi.org/10.1016/S0095-9561(16)33172-3
Blasco J, DelValls A (2008) Impact of emergent contaminants in the environment: environmental
risk assessment. Hdb Env Chem 5(S/1):169–188. https://doi.org/10.1007/698_5_107
Brennecke JF, Maginn EJ (2001) Ionic liquids: innovative fluids for chemical processing. AICHE
J 47:2384–2389. https://doi.org/10.1002/aic.690471102
Bubalo MC, Vidović S, Redovniković IR, Jokić S (2015) Green solvents for green technologies. J
Chem Technol Biotechnol 90:1631–1639. https://doi.org/10.1002/jctb.4668
Buckley MM, Benfield P (1993) Eutectic lidocaine/prilocaine cream: a review of the topical
anaesthetic/analgesic efficacy of a eutectic mixture of local anaesthetics (EMLA). Drugs
46:126–151. https://doi.org/10.2165/00003495-199346010-00008
Chavda HP, Patel CN, Anand IS (2010) Biopharmaceutics classification system. Sys Rev Pharm
(1):62–69
Cherukuvada S (2016) On the issues of resolving a low melting combination as a definite eutectic
or an elusive cocrystal: a critical evaluation. J Chem Sci 128:487–499. https://doi.org/10.1007/
s12039-016-1055-7
Cherukuvada S, Nangia A (2014) Eutectics as improved pharmaceutical materials: design, properties and characterization. Chem Commun 50:906–923. https://doi.org/10.1039/c3cc47521b
Choi YH, Spronsen JV, Dai Y, Verberne M, Hollmann F, Arends IWCE, Witkamp GJ, Verpoorte R
(2011) Are natural deep eutectic solvents the missing link in understanding cellular metabolism
and physiology? Plant Physiol 156:1701–1705. https://doi.org/10.1104/pp.111.178426
Cizmas L, Sharma VK, Gray CM, McDonald TJ (2015) Pharmaceuticals and personal care products in waters: occurrence, toxicity, and risk. Environ Chem Lett 13:381–394. https://doi.
org/10.1007/s10311-015-0524-4
Craveiro R, Aroso I, Flammia V, Carvalho T, Viciosa MT, Dionísio M, Barreiros S, Reis RL,
Duarte ARC, Paiva A (2016) Properties and thermal behavior of natural deep eutectic solvents.
J Mol Liq 215:534–540. https://doi.org/10.1016/j.molliq.2016.01.038
Dai Y, Spronsen JV, Witkamp GJ, Verpoorte R, Choi YH (2013) Natural deep eutectic solvents as new potential media for green technology. Anal Chim Acta 766:61–68. https://doi.
org/10.1016/j.aca.2012.12.019
Dai Y, Witkamp GJ, Verpoorte R, Choi YH (2015) Tailoring properties of natural deep eutectic solvents with water to facilitate their applications. Food Chem 187:14–19. https://doi.
org/10.1016/j.foodchem.2015.03.123
Dias AR, Costa-Rodrigues J, Fernandes MH, Ferraz R, Prudêncio C (2017) The anticancer potential of ionic liquids. Chem Med Chem 12:11–18. https://doi.org/10.1002/cmdc.201600480
Dichi E, Sghaier M, Guiblin N (2018) Reinvestigation of the paracetamol-caffeine, aspirin-caffeine
and paracetamol-aspirin phase equilibria diagrams. J Therm Anal Calorim 131:2141–2155.
https://doi.org/10.1007/s10973-017-6855-6
Domingos S, André V, Quaresma S, Martins ICB, Piedade MFM, Duarte MT (2015) New forms
of old drugs: improving without changing. J Pharm Pharmacol 67:830–846. https://doi.
org/10.1111/jphp.12384
Domínguez de María P, Maugeri Z (2011) Ionic liquids in biotransformations: from proof-ofconcept to emerging deep-eutectic-solvents. Curr Opin Chem Biol 15:220–225. https://doi.
org/10.1016/j.cbpa.2010.11.008
Duarte ARC, Ferreira ASD, Barreiros S, Cabrita E, Reis RL, Paiva A (2017) A comparison
between pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: solubility and permeability studies. Eur J Pharm Biopharm 114:296–304. https://doi.org/10.1016/j.
ejpb.2017.02.003
Dunn PJ (2012) The importance of green chemistry in process research and development. Chem
Soc Rev 41:1452–1461. https://doi.org/10.1039/c1cs15041c
3 Therapeutic Deep Eutectic Systems for the Enhancement of Drug Bioavailability