126
Durand E, Lecomte J, Villeneuve P (2016) From green chemistry to nature: the versatile role
of low transition temperature mixtures. Biochimie 120:119–123. https://doi.org/10.1016/j.
biochi.2015.09.019
Evers H, Dardel OV, Juhlin L, Ohlsen L, Vinnars E (1985) Dermal effects of compositions based
on the eutectic mixture of lignocaine and prilocaine (EMLA). Br J Anaesth 57:997–1005.
https://doi.org/10.1093/bja/57.10.997
Faggian M, Sut S, Perissutti B, Baldan V, Grabnar I, Dall’Acqua S (2016) Natural deep eutectic
solvents (NADES) as a tool for bioavailability improvement: pharmacokinetics of rutin dissolved in proline/glycine after oral administration in rats: possible application in nutraceuticals.
Molecules 21:1531–1542. https://doi.org/10.3390/molecules21111531
Ferraz R, Branco LC, Prudêncio C, Noronha JP, Petrovski Z (2011) Ionic liquids as active pharmaceutical ingredients. Chem Med Chem 6:975–985. https://doi.org/10.1002/cmdc.201100082
Fiala S, Jones SA, Brown MB (2010) A fundamental investigation into the effects of eutectic
formation on transmembrane transport. Int J Pharm 393:68–73. https://doi.org/10.1016/j.
ijpharm.2010.04.001
Francisco M, Bruinhorst AVD, Kroon MC (2013) Low-transition-temperature mixtures (LTTMs):
a new generation of designer solvents. Angew Chem Int Ed 52:3074–3085. https://doi.
org/10.1002/anie.201207548
Gala U, Chuong MC, Varanasi R, Chauhan H (2014) Characterization and comparison of
lidocaine- tetracaine and lidocaine-camphor eutectic mixtures based on their crystallization
and hydrogen-bonding abilities. AAPS Pharm Sci Tech 16:528–536. https://doi.org/10.1208/
s12249-014-0242-4
García-Argüelles S, Serrano MC, Gutiérrez MC, Ferrer ML, Yuste L, Rojo F, Del Monte F (2013)
Deep eutectic solvent-assisted synthesis of biodegradable polyesters with antibacterial properties. Langmuir 29:9525–9534. https://doi.org/10.1021/la401353r
Goldberg AH, Gibaldi M, Kanig JL (1966) Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures II: experimental evaluation of a eutectic mixture: urea-acetaminophen systems. J Pharm Sci 55:482–487. https://doi.org/10.1002/
jps.2600550507
Goud NR, Suresh K, Sanphui P, Nangia A (2012) Fast dissolving eutectic compositions of curcumin. Int J Pharm 439:63–72. https://doi.org/10.1016/j.ijpharm.2012.09.045
Gutiérrez MC, Ferrer ML, Mateo CR, Monte F (2009) Freeze-drying of aqueous solutions of deep
eutectic solvents: a suitable approach to deep eutectic suspensions of self-assembled structures.
Langmuir 25:5509–5515. https://doi.org/10.1021/la900552b
Guney O, Akgerman A (2002) Synthesis of controlled-release products in supercritical medium.
AICHE J 48:856–866. https://doi.org/10.1002/aic.690480419
Guthrie F (1884) On eutexia. The London, Edinburgh, and Dublin Philosophical Magazine and. J
Sci 17:462–482. https://doi.org/10.1080/14786448408627543
Gutiérrez A, Atilhan M, Aparicio S (2018) A theoretical study on lidocaine solubility in deep eutectic solvents. Phys Chem Chem Phys 20:27464–27473. https://doi.org/10.1039/c8cp05641b
Hayyan M, Looi CY, Hayyan A, Wong WF, Hashim MA (2015) In vitro and in vivo toxicity profiling of ammonium-based deep eutectic solvents. PLoS One 10:1–18. https://doi.org/10.1371/
journal.pone.0117934
Hayyan M, Mbous YP, Looi CY, Wong WF, Hayyan A, Salleh Z, Mohd-Ali O (2016) Natural
deep eutectic solvents: cytotoxic profile. Springer Plus 5:913–925. https://doi.org/10.1186/
s40064-016-2575-9
Heckenbach ME, Romero FN, Green MD, Halden RU (2016) Meta-analysis of ionic liquid literature and toxicology. Chemosphere 150:266–274. https://doi.org/10.1016/j.
chemosphere.2016.02.029
Hough WL, Rogers RD (2007) Ionic liquids then and now: from solvents to materials to active
pharmaceutical ingredients. Bull Chem Soc Jpn 80:2262–2269. https://doi.org/10.1246/
bcsj.80.2262
F. Santos and A. R. C. Duarte
Durand E, Lecomte J, Villeneuve P (2016) From green chemistry to nature: the versatile role
of low transition temperature mixtures. Biochimie 120:119–123. https://doi.org/10.1016/j.
biochi.2015.09.019
Evers H, Dardel OV, Juhlin L, Ohlsen L, Vinnars E (1985) Dermal effects of compositions based
on the eutectic mixture of lignocaine and prilocaine (EMLA). Br J Anaesth 57:997–1005.
https://doi.org/10.1093/bja/57.10.997
Faggian M, Sut S, Perissutti B, Baldan V, Grabnar I, Dall’Acqua S (2016) Natural deep eutectic
solvents (NADES) as a tool for bioavailability improvement: pharmacokinetics of rutin dissolved in proline/glycine after oral administration in rats: possible application in nutraceuticals.
Molecules 21:1531–1542. https://doi.org/10.3390/molecules21111531
Ferraz R, Branco LC, Prudêncio C, Noronha JP, Petrovski Z (2011) Ionic liquids as active pharmaceutical ingredients. Chem Med Chem 6:975–985. https://doi.org/10.1002/cmdc.201100082
Fiala S, Jones SA, Brown MB (2010) A fundamental investigation into the effects of eutectic
formation on transmembrane transport. Int J Pharm 393:68–73. https://doi.org/10.1016/j.
ijpharm.2010.04.001
Francisco M, Bruinhorst AVD, Kroon MC (2013) Low-transition-temperature mixtures (LTTMs):
a new generation of designer solvents. Angew Chem Int Ed 52:3074–3085. https://doi.
org/10.1002/anie.201207548
Gala U, Chuong MC, Varanasi R, Chauhan H (2014) Characterization and comparison of
lidocaine- tetracaine and lidocaine-camphor eutectic mixtures based on their crystallization
and hydrogen-bonding abilities. AAPS Pharm Sci Tech 16:528–536. https://doi.org/10.1208/
s12249-014-0242-4
García-Argüelles S, Serrano MC, Gutiérrez MC, Ferrer ML, Yuste L, Rojo F, Del Monte F (2013)
Deep eutectic solvent-assisted synthesis of biodegradable polyesters with antibacterial properties. Langmuir 29:9525–9534. https://doi.org/10.1021/la401353r
Goldberg AH, Gibaldi M, Kanig JL (1966) Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions and eutectic mixtures II: experimental evaluation of a eutectic mixture: urea-acetaminophen systems. J Pharm Sci 55:482–487. https://doi.org/10.1002/
jps.2600550507
Goud NR, Suresh K, Sanphui P, Nangia A (2012) Fast dissolving eutectic compositions of curcumin. Int J Pharm 439:63–72. https://doi.org/10.1016/j.ijpharm.2012.09.045
Gutiérrez MC, Ferrer ML, Mateo CR, Monte F (2009) Freeze-drying of aqueous solutions of deep
eutectic solvents: a suitable approach to deep eutectic suspensions of self-assembled structures.
Langmuir 25:5509–5515. https://doi.org/10.1021/la900552b
Guney O, Akgerman A (2002) Synthesis of controlled-release products in supercritical medium.
AICHE J 48:856–866. https://doi.org/10.1002/aic.690480419
Guthrie F (1884) On eutexia. The London, Edinburgh, and Dublin Philosophical Magazine and. J
Sci 17:462–482. https://doi.org/10.1080/14786448408627543
Gutiérrez A, Atilhan M, Aparicio S (2018) A theoretical study on lidocaine solubility in deep eutectic solvents. Phys Chem Chem Phys 20:27464–27473. https://doi.org/10.1039/c8cp05641b
Hayyan M, Looi CY, Hayyan A, Wong WF, Hashim MA (2015) In vitro and in vivo toxicity profiling of ammonium-based deep eutectic solvents. PLoS One 10:1–18. https://doi.org/10.1371/
journal.pone.0117934
Hayyan M, Mbous YP, Looi CY, Wong WF, Hayyan A, Salleh Z, Mohd-Ali O (2016) Natural
deep eutectic solvents: cytotoxic profile. Springer Plus 5:913–925. https://doi.org/10.1186/
s40064-016-2575-9
Heckenbach ME, Romero FN, Green MD, Halden RU (2016) Meta-analysis of ionic liquid literature and toxicology. Chemosphere 150:266–274. https://doi.org/10.1016/j.
chemosphere.2016.02.029
Hough WL, Rogers RD (2007) Ionic liquids then and now: from solvents to materials to active
pharmaceutical ingredients. Bull Chem Soc Jpn 80:2262–2269. https://doi.org/10.1246/
bcsj.80.2262
F. Santos and A. R. C. Duarte