124
3.4 Conclusion
The present review emphasizes the importance and evolution of therapeutic deep
eutectic solvents. THEDES are systems that have an infinite number of possible
combinations of its components, which allows the modulation of their features and
the application in different pharmaceutical formulations. For pharmaceutical
research, it is important to have this possibility that involves less toxicity, improves
the properties of the drugs, is cost-effective, and is an ecological alternative to the
preparation of enhanced biopharmaceuticals.
Acknowledgments The research leading to these results has received funding from the European
Union Horizon 2020 Programme under the agreement number ERC-2016-CoG 725034 (ERC
Consolidator Grant Des.solve). This work was supported also by the Associate Laboratory for
Green Chemistry-LAQV which is financed by the ERDF under the PT2020 Partnership Agreement
(POCI-01-0145-FEDER-007265).
References
Abbott AP, Capper G, Davies DL, Rasheed RK, Tambyrajah V (2003) Novel solvent properties
of choline chloride/urea mixtures. Chem Commun:70–71. https://doi.org/10.1039/B210714G
Abbott AP, Boothby D, Capper G, Davies DL, Rasheed R (2004) Deep eutectic solvents formed
between choline chloride and carboxylic acids. J Am Chem Soc 126:9142–9147. https://doi.
org/10.1021/ja048266j
Abbott AP, Capper G, Gray S (2006) Design of improved deep eutectic solvents using hole theory.
ChemPhysChem 7:803–806. https://doi.org/10.1002/cphc.200500489
Abbott AP, Ahmed EI, Prasad K, Qader IB, Ryder KS (2017) Liquid pharmaceuticals formulation
by eutectic formation. Fluid Phase Equilib 448:2–8. https://doi.org/10.1016/j.fluid.2017.05.009
Ali H, Khan E (2017) Environmental chemistry in the twenty-first century. Environ Chem Lett
15:329–346. https://doi.org/10.1007/s10311-016-0601-3
Álvarez MS, Zhang Y (2019) Sketching neoteric solvents for boosting drugs bioavailability. J
Control Release 311–312:225–232. https://doi.org/10.1016/j.jconrel.2019.09.008
Anastas P, Eghbali N (2010) Green chemistry: principles and practice. Chem Soc Rev 39:301–312.
https://doi.org/10.1039/b918763b
Anastas PT, Kirchhoff MM (2002) Origins, current status, and future challenges of green chemistry. Acc Chem Res 35:686–694. https://doi.org/10.1021/ar010065m
Anastas PT, Warner JC (1998) Green chemistry: theory and practice. Oxford University Press.
ISBN: 9780198506980
Aroso IM, Craveiro R, Rocha A, Dionísio M, Barreiros S, Reis RL, Paiva A, Duarte ARC
(2015) Design of controlled release systems for THEDES — therapeutic deep eutectic solvents, using supercritical fluid technology. Int J Pharm 492:73–979. https://doi.org/10.1016/j.
ijpharm.2015.06.038
Aroso IM, Silva JC, Mano F, Ferreira ASD, Dionísio M, Sá-nogueira I, Barreiros S, Reis RL,
Paiva A, Duarte ARC (2016) Dissolution enhancement of active pharmaceutical ingredients by
therapeutic deep eutectic systems. Eur J Pharm Biopharm 98:57–66. https://doi.org/10.1016/j.
ejpb.2015.11.002
Banerjee A, Ibsen K, Iwao Y, Zakrewsky M, Mitragotri S (2017) Transdermal protein delivery
using choline and geranate (CAGE) deep eutectic solvent. Adv Healthc Mater 6:1–11. https://
doi.org/10.1002/adhm.201601411
F. Santos and A. R. C. Duarte
3.4 Conclusion
The present review emphasizes the importance and evolution of therapeutic deep
eutectic solvents. THEDES are systems that have an infinite number of possible
combinations of its components, which allows the modulation of their features and
the application in different pharmaceutical formulations. For pharmaceutical
research, it is important to have this possibility that involves less toxicity, improves
the properties of the drugs, is cost-effective, and is an ecological alternative to the
preparation of enhanced biopharmaceuticals.
Acknowledgments The research leading to these results has received funding from the European
Union Horizon 2020 Programme under the agreement number ERC-2016-CoG 725034 (ERC
Consolidator Grant Des.solve). This work was supported also by the Associate Laboratory for
Green Chemistry-LAQV which is financed by the ERDF under the PT2020 Partnership Agreement
(POCI-01-0145-FEDER-007265).
References
Abbott AP, Capper G, Davies DL, Rasheed RK, Tambyrajah V (2003) Novel solvent properties
of choline chloride/urea mixtures. Chem Commun:70–71. https://doi.org/10.1039/B210714G
Abbott AP, Boothby D, Capper G, Davies DL, Rasheed R (2004) Deep eutectic solvents formed
between choline chloride and carboxylic acids. J Am Chem Soc 126:9142–9147. https://doi.
org/10.1021/ja048266j
Abbott AP, Capper G, Gray S (2006) Design of improved deep eutectic solvents using hole theory.
ChemPhysChem 7:803–806. https://doi.org/10.1002/cphc.200500489
Abbott AP, Ahmed EI, Prasad K, Qader IB, Ryder KS (2017) Liquid pharmaceuticals formulation
by eutectic formation. Fluid Phase Equilib 448:2–8. https://doi.org/10.1016/j.fluid.2017.05.009
Ali H, Khan E (2017) Environmental chemistry in the twenty-first century. Environ Chem Lett
15:329–346. https://doi.org/10.1007/s10311-016-0601-3
Álvarez MS, Zhang Y (2019) Sketching neoteric solvents for boosting drugs bioavailability. J
Control Release 311–312:225–232. https://doi.org/10.1016/j.jconrel.2019.09.008
Anastas P, Eghbali N (2010) Green chemistry: principles and practice. Chem Soc Rev 39:301–312.
https://doi.org/10.1039/b918763b
Anastas PT, Kirchhoff MM (2002) Origins, current status, and future challenges of green chemistry. Acc Chem Res 35:686–694. https://doi.org/10.1021/ar010065m
Anastas PT, Warner JC (1998) Green chemistry: theory and practice. Oxford University Press.
ISBN: 9780198506980
Aroso IM, Craveiro R, Rocha A, Dionísio M, Barreiros S, Reis RL, Paiva A, Duarte ARC
(2015) Design of controlled release systems for THEDES — therapeutic deep eutectic solvents, using supercritical fluid technology. Int J Pharm 492:73–979. https://doi.org/10.1016/j.
ijpharm.2015.06.038
Aroso IM, Silva JC, Mano F, Ferreira ASD, Dionísio M, Sá-nogueira I, Barreiros S, Reis RL,
Paiva A, Duarte ARC (2016) Dissolution enhancement of active pharmaceutical ingredients by
therapeutic deep eutectic systems. Eur J Pharm Biopharm 98:57–66. https://doi.org/10.1016/j.
ejpb.2015.11.002
Banerjee A, Ibsen K, Iwao Y, Zakrewsky M, Mitragotri S (2017) Transdermal protein delivery
using choline and geranate (CAGE) deep eutectic solvent. Adv Healthc Mater 6:1–11. https://
doi.org/10.1002/adhm.201601411
F. Santos and A. R. C. Duarte