123
Table 3.3 (continued)
THEDES
Application
References
Menthol:ibuprofen (3:1)
Preparation of THEDES with API
(NSAID) incorporated in the system
for impregnation in polymer matrices
with supercritical CO 2
Aroso et al. (2015),
Barros et al.
(2017), and Duarte
et al. (2017)
Choline chloride:mandelic acid
(1:2)
Preparation of THEDES and
encapsulate them in gelatin fiber
membranes
Mano et al. (2016)
Choline chloride:ascorbic acid
(1:1), (1:2), (2:1)
Preparation of THEDES to dissolve
an API (dexamethasone), with
possible applications in tissue
engineering
Silva et al. (2018)
Choline chloride:lactic acid (1:1)
β-Alanine:lactic acid (1:1)
Solubility enhancement of lidocaine
in DES (theoretical study)
Gutiérrez et al.
(2018)
Choline chloride:glycerol (1:2)
Choline chloride:ethylene glycol
(1:2)
Solubility enhancement of
acetaminophen with DES
Shekaari et al.
(2018)
Citric acid:ethambutol:H 2 O
(2:1:10)
Citric acid:L-arginine:H 2 O (1:1:6)
Citric acid:L-arginine:H 2 O (1:1:7)
Citric acid:L-arginine:H 2 O (2:1:7)
Citric acid:L-arginine:H 2 O (2:1:8)
Citric acid:L-arginine:H 2 O (2:1:9)
Preparation of THEDES with API and
water incorporated in the system
Santos et al. (2019)
Choline chloride:sucrose:H2O
(4:1:4)
Choline chloride:glycerol:H2O
(1:2:1)
Preparation of DES for
functionalization of drug nanocarriers
of graphene
Zainal-Abidin et al.
(2019)
Menthol:lauric acid (1:1); (1:2);
(2:1); (4:1); (8:1)
Menthol:myristic acid (1:1); (2:1);
(4:1); (8:1); (10:1)
Menthol:stearic acid (4:1); (8:1);
(20:1)
Preparation and characterization of
THEDES with terpenes and fatty
acids with wound healing properties
Silva et al. (2019a,
b, c)
Lauric acid:myristic acid (1:1)
Preparation of eutectic blends and
loading onto gauzes
Silva et al. (2019a,
b, c)
Capric acid:lauric acid (2:1)
Capric acid:stearic acid (4:1)
Capric acid:myristic acid (3:1)
Preparation of different DES with
fatty acids with antimicrobial activity
and biofilm detachment
Silva et al. (2019a,
b, c)
Myristic acid:limonene (1:1);
(1:2); (2:1)
Capric acid:limonene (1:1); (1:2);
(2:1)
Menthol:limonene (1:1); (1:2);
(2:1)
Ibuprofen:limonene (1:1); (1:2);
(2:1); (4:1); (8:1)
Preparation of THEDES with
limonene and evaluate their antitumor
activity
Pereira et al. (2019)
Nimesulide:nicotinamide (1:2)
Direct preparation of compressible
dosage forms for drug delivery
Patel et al. (2019)
3 Therapeutic Deep Eutectic Systems for the Enhancement of Drug Bioavailability
Table 3.3 (continued)
THEDES
Application
References
Menthol:ibuprofen (3:1)
Preparation of THEDES with API
(NSAID) incorporated in the system
for impregnation in polymer matrices
with supercritical CO 2
Aroso et al. (2015),
Barros et al.
(2017), and Duarte
et al. (2017)
Choline chloride:mandelic acid
(1:2)
Preparation of THEDES and
encapsulate them in gelatin fiber
membranes
Mano et al. (2016)
Choline chloride:ascorbic acid
(1:1), (1:2), (2:1)
Preparation of THEDES to dissolve
an API (dexamethasone), with
possible applications in tissue
engineering
Silva et al. (2018)
Choline chloride:lactic acid (1:1)
β-Alanine:lactic acid (1:1)
Solubility enhancement of lidocaine
in DES (theoretical study)
Gutiérrez et al.
(2018)
Choline chloride:glycerol (1:2)
Choline chloride:ethylene glycol
(1:2)
Solubility enhancement of
acetaminophen with DES
Shekaari et al.
(2018)
Citric acid:ethambutol:H 2 O
(2:1:10)
Citric acid:L-arginine:H 2 O (1:1:6)
Citric acid:L-arginine:H 2 O (1:1:7)
Citric acid:L-arginine:H 2 O (2:1:7)
Citric acid:L-arginine:H 2 O (2:1:8)
Citric acid:L-arginine:H 2 O (2:1:9)
Preparation of THEDES with API and
water incorporated in the system
Santos et al. (2019)
Choline chloride:sucrose:H2O
(4:1:4)
Choline chloride:glycerol:H2O
(1:2:1)
Preparation of DES for
functionalization of drug nanocarriers
of graphene
Zainal-Abidin et al.
(2019)
Menthol:lauric acid (1:1); (1:2);
(2:1); (4:1); (8:1)
Menthol:myristic acid (1:1); (2:1);
(4:1); (8:1); (10:1)
Menthol:stearic acid (4:1); (8:1);
(20:1)
Preparation and characterization of
THEDES with terpenes and fatty
acids with wound healing properties
Silva et al. (2019a,
b, c)
Lauric acid:myristic acid (1:1)
Preparation of eutectic blends and
loading onto gauzes
Silva et al. (2019a,
b, c)
Capric acid:lauric acid (2:1)
Capric acid:stearic acid (4:1)
Capric acid:myristic acid (3:1)
Preparation of different DES with
fatty acids with antimicrobial activity
and biofilm detachment
Silva et al. (2019a,
b, c)
Myristic acid:limonene (1:1);
(1:2); (2:1)
Capric acid:limonene (1:1); (1:2);
(2:1)
Menthol:limonene (1:1); (1:2);
(2:1)
Ibuprofen:limonene (1:1); (1:2);
(2:1); (4:1); (8:1)
Preparation of THEDES with
limonene and evaluate their antitumor
activity
Pereira et al. (2019)
Nimesulide:nicotinamide (1:2)
Direct preparation of compressible
dosage forms for drug delivery
Patel et al. (2019)
3 Therapeutic Deep Eutectic Systems for the Enhancement of Drug Bioavailability