97
Esquembre R, Sanz JM, Wall JG, del Monte F, Mateo CR, Ferrer ML (2013) Thermal unfolding
and refolding of lysozyme in deep eutectic solvents and their aqueous dilutions. Phys Chem
Chem Phys 15:11248–11256. https://doi.org/10.1039/c3cp44299c
Faggian M, Sut S, Perissutti B, Baldan V, Grabnar I, Dall’Acqua S (2016) Natural deep eutectic
solvents (NADES) as a tool for bioavailability improvement: pharmacokinetics of rutin dissolved in proline/glycine after oral administration in rats: possible application in nutraceuticals.
Molecules 21:E1531. https://doi.org/10.3390/molecules21111531
Florindo C, Celia-Silva LG, Martins LFG, Branco LC, Marrucho IM (2018) Supramolecular
hydrogel based on a sodium deep eutectic solvent. Chem Commun 54:7527–7530. https://doi.
org/10.1039/c8cc03266a
Fourmentin S, Landy D, Cunha Gomes de Moura LM, Tilloy S, Bricout H, Ferreira M (2018)
Procédé d’épuration d’un effluent gazeux. FR3058905
Fu N, Li L, Liu K, Kim CK, Li J, Zhu T, Li J, Tang B (2019) A choline chloride-acrylic acid deep
eutectic solvent polymer based on Fe3O4 particles and MoS2 sheets (poly(ChCl-AA DES)@
Fe3O4@MoS2) with specific recognition and good antibacterial properties for β-lactoglobulin
in milk. Talanta 197:567–577. https://doi.org/10.1016/j.talanta.2019.01.072
Gállego I, Grover MA, Hud NV (2015) Folding and imaging of DNA nanostructures in anhydrous and hydrated deep-eutectic solvents. Angew Chem Int Ed Engl 54:6765–6769. https://
doi.org/10.1002/anie.201412354
Gautam RK, Ahmed SA, Seth D (2018) Photophysics of thioflavin T in deep eutectic solvents. J
Lumin 198:508–516. https://doi.org/10.1016/j.jlumin.2018.02.055
Gutiérrez A, Atilhan M, Aparicio S (2018) A theoretical study on lidocaine solubility in deep eutectic solvents. Phys Chem Chem Phys 20:27464–27473. https://doi.org/10.1039/c8cp05641b
Gutiérrez A, Aparicio S, Atilhan M (2019) Design of arginine-based therapeutic deep eutectic solvents as drug solubilization vehicles for active pharmaceutical ingredients. Phys Chem Chem
Phys 21:10621–10634. https://doi.org/10.1039/c9cp01408j
Halder AK, Natalia M, Cordeiro DS (2019) Probing the environmental toxicity of deep eutectic solvents and their components: an in silico modeling approach. ACS Sustain Chem Eng
7:10649–10660. https://doi.org/10.1021/acssuschemeng.9b01306
Haraźna K, Walas K, Urbańska P, Witko T, Snoch W, Siemek A, Jachimska B, Krzan M,
Napruszewska BD, Witko M, Bednarz S, Guzik M (2019) Polyhydroxyalkanoate-derived
hydrogen-bond donors for the synthesis of new deep eutectic solvents. Green Chem
21:3116–3126. https://doi.org/10.1039/C9GC00387H
Harifi-Mood AR, Ghobadi R, Divsalar A (2017) The effect of deep eutectic solvents on catalytic
function and structure of bovine liver catalase. Int J Biol Macromol 95:115–120. https://doi.
org/10.1016/j.ijbiomac.2016.11.043
Hattori T, Tagawa H, Inai M, Kan T, Kimura S, Itai S, Mitragotri S, Iwao Y (2019) Transdermal
delivery of nobiletin using ionic liquids. Sci Rep 9:20191. https://doi.org/10.1038/
s41598-019-56731-1
Hayyan M, Hashim MA, Hayyan A, Al-Saadi MA, AlNashef IM, Mirghani ME, Saheed OK
(2013) Are deep eutectic solvents benign or toxic? Chemosphere 90:2193–2195. https://doi.
org/10.1016/j.chemosphere.2012.11.004
Hayyan M, Looi CY, Hayyan A, Wong WF, Hashim MA (2015) In vitro and in vivo toxicity
profiling of ammonium-based deep eutectic solvents. PLoS One 10:e0117934. https://doi.
org/10.1371/journal.pone.0117934
Hayyan M, Mbous YP, Looi CY, Wong WF, Hayyan A, Salleh Z, Mohd-Ali O (2016) Natural
deep eutectic solvents: cytotoxic profile. Springerplus 5:913. https://doi.org/10.1186/
s40064-016-2575-9
Ibsen KN, Ma H, Banerjee A, Tanner EEL, Nangia S, Mitragotri S (2018) Mechanism of antibacterial activity of choline-based ionic liquids (CAGE). ACS Biomater Sci Eng 4:2370–2379.
https://doi.org/10.1021/acsbiomaterials.8b00486
Jeliński T, Przybyłek M, Cysewski P (2019a) Solubility advantage of sulfanilamide and sulfacetamide in natural deep eutectic systems: experimental and theoretical investigations. Drug Dev
Ind Pharm 45:1120–1129. https://doi.org/10.1080/03639045.2019.1597104
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations
Esquembre R, Sanz JM, Wall JG, del Monte F, Mateo CR, Ferrer ML (2013) Thermal unfolding
and refolding of lysozyme in deep eutectic solvents and their aqueous dilutions. Phys Chem
Chem Phys 15:11248–11256. https://doi.org/10.1039/c3cp44299c
Faggian M, Sut S, Perissutti B, Baldan V, Grabnar I, Dall’Acqua S (2016) Natural deep eutectic
solvents (NADES) as a tool for bioavailability improvement: pharmacokinetics of rutin dissolved in proline/glycine after oral administration in rats: possible application in nutraceuticals.
Molecules 21:E1531. https://doi.org/10.3390/molecules21111531
Florindo C, Celia-Silva LG, Martins LFG, Branco LC, Marrucho IM (2018) Supramolecular
hydrogel based on a sodium deep eutectic solvent. Chem Commun 54:7527–7530. https://doi.
org/10.1039/c8cc03266a
Fourmentin S, Landy D, Cunha Gomes de Moura LM, Tilloy S, Bricout H, Ferreira M (2018)
Procédé d’épuration d’un effluent gazeux. FR3058905
Fu N, Li L, Liu K, Kim CK, Li J, Zhu T, Li J, Tang B (2019) A choline chloride-acrylic acid deep
eutectic solvent polymer based on Fe3O4 particles and MoS2 sheets (poly(ChCl-AA DES)@
Fe3O4@MoS2) with specific recognition and good antibacterial properties for β-lactoglobulin
in milk. Talanta 197:567–577. https://doi.org/10.1016/j.talanta.2019.01.072
Gállego I, Grover MA, Hud NV (2015) Folding and imaging of DNA nanostructures in anhydrous and hydrated deep-eutectic solvents. Angew Chem Int Ed Engl 54:6765–6769. https://
doi.org/10.1002/anie.201412354
Gautam RK, Ahmed SA, Seth D (2018) Photophysics of thioflavin T in deep eutectic solvents. J
Lumin 198:508–516. https://doi.org/10.1016/j.jlumin.2018.02.055
Gutiérrez A, Atilhan M, Aparicio S (2018) A theoretical study on lidocaine solubility in deep eutectic solvents. Phys Chem Chem Phys 20:27464–27473. https://doi.org/10.1039/c8cp05641b
Gutiérrez A, Aparicio S, Atilhan M (2019) Design of arginine-based therapeutic deep eutectic solvents as drug solubilization vehicles for active pharmaceutical ingredients. Phys Chem Chem
Phys 21:10621–10634. https://doi.org/10.1039/c9cp01408j
Halder AK, Natalia M, Cordeiro DS (2019) Probing the environmental toxicity of deep eutectic solvents and their components: an in silico modeling approach. ACS Sustain Chem Eng
7:10649–10660. https://doi.org/10.1021/acssuschemeng.9b01306
Haraźna K, Walas K, Urbańska P, Witko T, Snoch W, Siemek A, Jachimska B, Krzan M,
Napruszewska BD, Witko M, Bednarz S, Guzik M (2019) Polyhydroxyalkanoate-derived
hydrogen-bond donors for the synthesis of new deep eutectic solvents. Green Chem
21:3116–3126. https://doi.org/10.1039/C9GC00387H
Harifi-Mood AR, Ghobadi R, Divsalar A (2017) The effect of deep eutectic solvents on catalytic
function and structure of bovine liver catalase. Int J Biol Macromol 95:115–120. https://doi.
org/10.1016/j.ijbiomac.2016.11.043
Hattori T, Tagawa H, Inai M, Kan T, Kimura S, Itai S, Mitragotri S, Iwao Y (2019) Transdermal
delivery of nobiletin using ionic liquids. Sci Rep 9:20191. https://doi.org/10.1038/
s41598-019-56731-1
Hayyan M, Hashim MA, Hayyan A, Al-Saadi MA, AlNashef IM, Mirghani ME, Saheed OK
(2013) Are deep eutectic solvents benign or toxic? Chemosphere 90:2193–2195. https://doi.
org/10.1016/j.chemosphere.2012.11.004
Hayyan M, Looi CY, Hayyan A, Wong WF, Hashim MA (2015) In vitro and in vivo toxicity
profiling of ammonium-based deep eutectic solvents. PLoS One 10:e0117934. https://doi.
org/10.1371/journal.pone.0117934
Hayyan M, Mbous YP, Looi CY, Wong WF, Hayyan A, Salleh Z, Mohd-Ali O (2016) Natural
deep eutectic solvents: cytotoxic profile. Springerplus 5:913. https://doi.org/10.1186/
s40064-016-2575-9
Ibsen KN, Ma H, Banerjee A, Tanner EEL, Nangia S, Mitragotri S (2018) Mechanism of antibacterial activity of choline-based ionic liquids (CAGE). ACS Biomater Sci Eng 4:2370–2379.
https://doi.org/10.1021/acsbiomaterials.8b00486
Jeliński T, Przybyłek M, Cysewski P (2019a) Solubility advantage of sulfanilamide and sulfacetamide in natural deep eutectic systems: experimental and theoretical investigations. Drug Dev
Ind Pharm 45:1120–1129. https://doi.org/10.1080/03639045.2019.1597104
2 Deep Eutectic Solvents for Innovative Pharmaceutical Formulations