96
Aroso IM, Silva JC, Mano F, Ferreira AS, Dionísio M, Sá-Nogueira I, Barreiros S, Reis RL,
Paiva A, Duarte AR (2016) Dissolution enhancement of active pharmaceutical ingredients by
therapeutic deep eutectic systems. Eur J Pharm Biopharm 98:57–66. https://doi.org/10.1016/j.
ejpb.2015.11.002
Banerjee A, Ibsen K, Iwao Y, Zakrewsky M, Mitragotri S (2017) Transdermal protein delivery
using choline and geranate (CAGE) deep eutectic solvent. Adv Healthc Mater 6:1601411.
https://doi.org/10.1002/adhm.201601411
Banerjee A, Ibsen K, Brown T, Chen R, Agatemor C, Mitragotri S (2018a) Ionic liquids for
oral insulin delivery. Proc Natl Acad Sci U S A 115:7296–7301. https://doi.org/10.1073/
pnas.1722338115
Banerjee A, Ibsen K, Brown T, Chen R, Agatemor C, Mitragotri S (2018b) Reply to Rogers
and Gurau: definitions of ionic liquids and deep eutectic solvents. Proc Natl Acad Sci U S A
115:E11000–E11001. https://doi.org/10.1073/pnas.1815526115
Barros AA, Silva JM, Craveiro R, Paiva A, Reis RL, Duarte ARC (2017) Green solvents for
enhanced impregnation processes in biomedicine. Curr Opin Green Sustain Chem 5:82–87.
https://doi.org/10.1016/j.cogsc.2017.03.014
Benlebna M, Ruesgas-Ramón M, Bonafos B, Fouret G, Casas F, Coudray C, Durand E, Cruz
Figueroa-Espinoza M, Feillet-Coudray C (2018) Toxicity of natural deep eutectic solvent
betaine:glycerol in rats. J Agric Food Chem 66:6205–6212. https://doi.org/10.1021/acs.
jafc.8b01746
Chen J, Li SF, Yao ZF, Yanga DW, Zhang LW (2016) Improved stability of salvianolic acid B from
Radix Salviae miltiorrhizae in deep eutectic solvents. Ana Methods 8:2502–2509. https://doi.
org/10.1039/C5AY03351A
Chen J, Wang Q, Liu M, Zhang L (2017) The effect of deep eutectic solvent on the pharmacokinetics of salvianolic acid B in rats and its acute toxicity test. J Chromatogr B Analyt Technol
Biomed Life Sci 1063:60–66. https://doi.org/10.1016/j.jchromb.2017.08.016
Choi YH, van Spronsen J, Dai Y, Verberne M, Hollmann F, Arends IWCE, Witkamp GJ, Verpoorte
R (2011) Are natural deep eutectic solvents the missing link in understanding cellular metabolism and physiology? Plant Physiol 156:1701–1705. https://doi.org/10.1104/pp.111.178426
Colombo Dugoni G, Di Pietro ME, Ferro M, Castiglione F, Ruellan S, Moufawad T, Moura L,
Costa Gomes MF, Fourmentin S, Mele A (2019) Effect of water on deep eutectic solvent/
β-cyclodextrin systems. ACS Sustain Chem Eng 7:7277–7285. https://doi.org/10.1021/
acssuschemeng.9b00315
Dai Y, van Spronsen J, Witkamp GJ, Verpoorte R, Choi YH (2013) Natural deep eutectic solvents as new potential media for green technology. Anal Chim Acta 766:61–68. https://doi.
org/10.1016/j.aca.2012.12.019
Dai Y, Witkamp GJ, Verpoorte R, Choi YH (2015) Tailoring properties of natural deep eutectic solvents with water to facilitate their applications. Food Chem 187:14–19. https://doi.
org/10.1016/j.foodchem.2015.03.123
Duarte AR, Ferreira AS, Barreiros S, Cabrita E, Reis RL, Paiva A (2017) A comparison between
pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: solubility
and permeability studies. Eur J Pharm Biopharm 114:296–304. https://doi.org/10.1016/j.
ejpb.2017.02.003
Durand E, Lecomte J, Villeneuve P (2016) From green chemistry to nature: the versatile role
of low transition temperature mixtures. Biochimie 120:119–123. https://doi.org/10.1016/j.
biochi.2015.09.019
Durand E, Lecomte J, Upasani R, Chabi B, Bayrasy C, Baréa B, Jublanc E, Clarke MJ, Moore DJ,
Crowther J, Wrutniak-Cabello C, Villeneuve P (2017) Evaluation of the ROS inhibiting activity and mitochondrial targeting of phenolic compounds in fibroblast cells model system and
enhancement of efficiency by natural deep eutectic solvent (NADES) formulation. Pharm Res
34:1134–1146. https://doi.org/10.1007/s11095-017-2124-4
El Achkar T, Moufawad T, Ruellan S, Landy D, Greige-Gerges H, Fourmentin S (2020)
Cyclodextrins: from solute to solvent. Chem Commun 56:3385−3388. https://doi.org/10.1039/
D0CC00460J
C.-H. Nguyen et al.
Aroso IM, Silva JC, Mano F, Ferreira AS, Dionísio M, Sá-Nogueira I, Barreiros S, Reis RL,
Paiva A, Duarte AR (2016) Dissolution enhancement of active pharmaceutical ingredients by
therapeutic deep eutectic systems. Eur J Pharm Biopharm 98:57–66. https://doi.org/10.1016/j.
ejpb.2015.11.002
Banerjee A, Ibsen K, Iwao Y, Zakrewsky M, Mitragotri S (2017) Transdermal protein delivery
using choline and geranate (CAGE) deep eutectic solvent. Adv Healthc Mater 6:1601411.
https://doi.org/10.1002/adhm.201601411
Banerjee A, Ibsen K, Brown T, Chen R, Agatemor C, Mitragotri S (2018a) Ionic liquids for
oral insulin delivery. Proc Natl Acad Sci U S A 115:7296–7301. https://doi.org/10.1073/
pnas.1722338115
Banerjee A, Ibsen K, Brown T, Chen R, Agatemor C, Mitragotri S (2018b) Reply to Rogers
and Gurau: definitions of ionic liquids and deep eutectic solvents. Proc Natl Acad Sci U S A
115:E11000–E11001. https://doi.org/10.1073/pnas.1815526115
Barros AA, Silva JM, Craveiro R, Paiva A, Reis RL, Duarte ARC (2017) Green solvents for
enhanced impregnation processes in biomedicine. Curr Opin Green Sustain Chem 5:82–87.
https://doi.org/10.1016/j.cogsc.2017.03.014
Benlebna M, Ruesgas-Ramón M, Bonafos B, Fouret G, Casas F, Coudray C, Durand E, Cruz
Figueroa-Espinoza M, Feillet-Coudray C (2018) Toxicity of natural deep eutectic solvent
betaine:glycerol in rats. J Agric Food Chem 66:6205–6212. https://doi.org/10.1021/acs.
jafc.8b01746
Chen J, Li SF, Yao ZF, Yanga DW, Zhang LW (2016) Improved stability of salvianolic acid B from
Radix Salviae miltiorrhizae in deep eutectic solvents. Ana Methods 8:2502–2509. https://doi.
org/10.1039/C5AY03351A
Chen J, Wang Q, Liu M, Zhang L (2017) The effect of deep eutectic solvent on the pharmacokinetics of salvianolic acid B in rats and its acute toxicity test. J Chromatogr B Analyt Technol
Biomed Life Sci 1063:60–66. https://doi.org/10.1016/j.jchromb.2017.08.016
Choi YH, van Spronsen J, Dai Y, Verberne M, Hollmann F, Arends IWCE, Witkamp GJ, Verpoorte
R (2011) Are natural deep eutectic solvents the missing link in understanding cellular metabolism and physiology? Plant Physiol 156:1701–1705. https://doi.org/10.1104/pp.111.178426
Colombo Dugoni G, Di Pietro ME, Ferro M, Castiglione F, Ruellan S, Moufawad T, Moura L,
Costa Gomes MF, Fourmentin S, Mele A (2019) Effect of water on deep eutectic solvent/
β-cyclodextrin systems. ACS Sustain Chem Eng 7:7277–7285. https://doi.org/10.1021/
acssuschemeng.9b00315
Dai Y, van Spronsen J, Witkamp GJ, Verpoorte R, Choi YH (2013) Natural deep eutectic solvents as new potential media for green technology. Anal Chim Acta 766:61–68. https://doi.
org/10.1016/j.aca.2012.12.019
Dai Y, Witkamp GJ, Verpoorte R, Choi YH (2015) Tailoring properties of natural deep eutectic solvents with water to facilitate their applications. Food Chem 187:14–19. https://doi.
org/10.1016/j.foodchem.2015.03.123
Duarte AR, Ferreira AS, Barreiros S, Cabrita E, Reis RL, Paiva A (2017) A comparison between
pure active pharmaceutical ingredients and therapeutic deep eutectic solvents: solubility
and permeability studies. Eur J Pharm Biopharm 114:296–304. https://doi.org/10.1016/j.
ejpb.2017.02.003
Durand E, Lecomte J, Villeneuve P (2016) From green chemistry to nature: the versatile role
of low transition temperature mixtures. Biochimie 120:119–123. https://doi.org/10.1016/j.
biochi.2015.09.019
Durand E, Lecomte J, Upasani R, Chabi B, Bayrasy C, Baréa B, Jublanc E, Clarke MJ, Moore DJ,
Crowther J, Wrutniak-Cabello C, Villeneuve P (2017) Evaluation of the ROS inhibiting activity and mitochondrial targeting of phenolic compounds in fibroblast cells model system and
enhancement of efficiency by natural deep eutectic solvent (NADES) formulation. Pharm Res
34:1134–1146. https://doi.org/10.1007/s11095-017-2124-4
El Achkar T, Moufawad T, Ruellan S, Landy D, Greige-Gerges H, Fourmentin S (2020)
Cyclodextrins: from solute to solvent. Chem Commun 56:3385−3388. https://doi.org/10.1039/
D0CC00460J
C.-H. Nguyen et al.