69
is the stabilization of flavors and aromas. α-Cyclodextrin, being non-digestible, is
recognized a dietary fiber with beneficial effects on digestion of fat and carbohydrates (Artiss et al. 2006). It has been marketed for body weight control in several
countries. Further studies and industrial developments are expected in the near
future in the following domains: functional food, nutritional supplements, nutraceuticals, wrapping materials, and packaging. One of the most promising functional
food groups is those enriched in antioxidant compounds of a lipophilic nature
(Fenyvesi and Szente 2016; Kfoury et al. 2016; Zarzycki et al. 2016).
Other applications have been reported in sectors such as supramolecular catalysis (Hapiot et al. 2014; Chen et al. 2019; Fernandez et al. 2019), asymmetric and
stereospecific synthesis (Macaev and Boldescu 2015), click chemistry (Celebioglu
et al. 2016; Hou et al. 2016), metal-organic frameworks (Rajkumar et al. 2019),
agrochemistry (Campos et al. 2015; Yusoff et al. 2016), supercritical fluid chromatography (Xiao et al. 2012; West 2014), imprinting techniques (Lay et al. 2016),
nanofibers (Topuz and Uyar 2019), and environment (Taka et al. 2017; Crini
et al. 2018).
Research on cyclodextrins is also very active in fields such as the formulation of
detergents and sugar-based surfactants (Valente and Söderman 2014), glues and
adhesives (Osaki 2019), silicon industry (Grachev et al. 2019), flame-retardant formulation (Luda and Zanetti 2019), the sector of plastics for packaging or for automotive (Szente and Fenyvesi 2018), the industry of fibers and paper, soil remediation
(Atteia et al. 2013; Lau et al. 2014; Madrid et al. 2019; Gruiz et al. 2019), materials
for wastewater treatment (Cova et al. 2018; Morin-Crini et al. 2018; Barbosa et al.
2019), biodiesel production (Zhang et al. 2018), and hydrogen storage (Han
et al. 2018).
The slide ring gels (polyrotaxane gels) found their application in the car industry
and telecommunication (Ito 2017; Kashiwagi et al. 2018; Jiang et al. 2018). There
are also many possibilities for the development of new textiles and cosmetic products, called cosmetotextiles (Singh et al. 2011), with advanced properties (Shende
and Trotta 2019; Yao et al. 2019). Their applications seem promising.
Cosmeceuticals containing cyclodextrins also seem to be a promising domain for
medicine, dermatology, and aromatherapy (Adeoye et al. 2017; Kaur et al. 2018).
These products are cosmetics with pharmaceutical and therapeutic benefits.
1.5 Conclusion
In this chapter, we described historical landmarks of the discovery, exploration, and
utilization of cyclodextrins, cyclic oligosaccharides obtained from the enzymatic
degradation of starch and discovered serendipitously in 1891 by Villiers. Of course,
this historical chapter cannot hope to be exhaustive, but it highlighted the work of
those researchers who have contributed to the knowledge of cyclodextrins throughout the 129 years of its history.
1 History of Cyclodextrins
is the stabilization of flavors and aromas. α-Cyclodextrin, being non-digestible, is
recognized a dietary fiber with beneficial effects on digestion of fat and carbohydrates (Artiss et al. 2006). It has been marketed for body weight control in several
countries. Further studies and industrial developments are expected in the near
future in the following domains: functional food, nutritional supplements, nutraceuticals, wrapping materials, and packaging. One of the most promising functional
food groups is those enriched in antioxidant compounds of a lipophilic nature
(Fenyvesi and Szente 2016; Kfoury et al. 2016; Zarzycki et al. 2016).
Other applications have been reported in sectors such as supramolecular catalysis (Hapiot et al. 2014; Chen et al. 2019; Fernandez et al. 2019), asymmetric and
stereospecific synthesis (Macaev and Boldescu 2015), click chemistry (Celebioglu
et al. 2016; Hou et al. 2016), metal-organic frameworks (Rajkumar et al. 2019),
agrochemistry (Campos et al. 2015; Yusoff et al. 2016), supercritical fluid chromatography (Xiao et al. 2012; West 2014), imprinting techniques (Lay et al. 2016),
nanofibers (Topuz and Uyar 2019), and environment (Taka et al. 2017; Crini
et al. 2018).
Research on cyclodextrins is also very active in fields such as the formulation of
detergents and sugar-based surfactants (Valente and Söderman 2014), glues and
adhesives (Osaki 2019), silicon industry (Grachev et al. 2019), flame-retardant formulation (Luda and Zanetti 2019), the sector of plastics for packaging or for automotive (Szente and Fenyvesi 2018), the industry of fibers and paper, soil remediation
(Atteia et al. 2013; Lau et al. 2014; Madrid et al. 2019; Gruiz et al. 2019), materials
for wastewater treatment (Cova et al. 2018; Morin-Crini et al. 2018; Barbosa et al.
2019), biodiesel production (Zhang et al. 2018), and hydrogen storage (Han
et al. 2018).
The slide ring gels (polyrotaxane gels) found their application in the car industry
and telecommunication (Ito 2017; Kashiwagi et al. 2018; Jiang et al. 2018). There
are also many possibilities for the development of new textiles and cosmetic products, called cosmetotextiles (Singh et al. 2011), with advanced properties (Shende
and Trotta 2019; Yao et al. 2019). Their applications seem promising.
Cosmeceuticals containing cyclodextrins also seem to be a promising domain for
medicine, dermatology, and aromatherapy (Adeoye et al. 2017; Kaur et al. 2018).
These products are cosmetics with pharmaceutical and therapeutic benefits.
1.5 Conclusion
In this chapter, we described historical landmarks of the discovery, exploration, and
utilization of cyclodextrins, cyclic oligosaccharides obtained from the enzymatic
degradation of starch and discovered serendipitously in 1891 by Villiers. Of course,
this historical chapter cannot hope to be exhaustive, but it highlighted the work of
those researchers who have contributed to the knowledge of cyclodextrins throughout the 129 years of its history.
1 History of Cyclodextrins