70
Expensive to produce, the three main native cyclodextrins, i.e., α-, β-, and
γ-cyclodextrins, were long considered just laboratory curiosities. Until the
mid- 1970s, the main obstacles were the lack of sufficient knowledge of these molecules, their high price, and also their presumed toxicity. In addition, very few
researchers were convinced of the industrial potential of cyclodextrins.
As reported in this comprehensive chapter, since Villiers’ discovery, several great
scientists, including Schardinger, Freudenberg, Cramer, French, and Szejtli, have
left their mark on the history, characterization, properties, and potential applications
of these molecules over a period of 86 years, from 1903, i.e., the first paper on
cyclodextrin chemistry published by Schardinger, to 1989, i.e., the creation by
Szejtli of the first company totally devoted to cyclodextrins.
Since the 1980s, cyclodextrins have considerably attracted the interest of scientists and industries in different disciplines including health science, agriculture,
chemistry, biochemistry, and environment. The main reason for this growing interest was their ability to form inclusion complexes with various molecules through
host-guest interactions.
Today, cyclodextrins continue to offer new horizons to scientists and industrials
with a wide range of possible modifications and forms for multiple classical, e.g.,
pharmacy, food industry, chromatography, cosmetology, and biotechnology, and
emerging, e.g., biomedicine, agrochemistry, and nanomaterials, applications.
References
Adeoye O, Figueiredo A, Cabral Marques H (2017) Chapter 13: Cyclodextrins and skin disorders: therapeutic and cosmetic applications. In: Ascenso A, Ribeiro H, Simões S (eds)
Carrier-mediated dermal delivery. Jenny Stanford Publishing, New York, 39 p. https://doi.
org/10.4324/9781315364476
Akiya S, Okui S (1951) Studies of the degeneration process of sugars. 3. Reactions of periodic acid
on 2 hexasaccharides. J Pharm Soc Japan 71:865–869
Akiya S, Watanabe T (1950a) A crystalline decomposition product of starch by a bacillus. 3. A new
strain of Bacillus macerans. J Pharm Soc Japan 70:572–576
Akiya S, Watanabe T (1950b) A crystalline decomposition product of starch by a bacillus. 4. A new
hexasaccharide. J Pharm Soc Japan 70:576–578
Akiya S, Watanabe T (1950c) A crystalline decomposition product of starch by a bacillus. 5.
Structure of the new hexasaccharide. J Pharm Soc Japan 70:579–582
Albers E, Muller BW (1995) Cyclodextrin derivatives in pharmaceutics. Crit Rev Ther Drug
Carrier Syst 12:311–337
Ammayappan L, Moses JJ (2009) An overview on application of cyclodextrins in textile product
enhancement. J Text Assoc 70:9–18
Andersen GH, Robbins FM, Domingues FJ, Moores RG, Long CL (1963) The utilization of
Schardinger dextrins by the rat. Toxicol Appl Pharmacol 5:257–266
Andreaus J, Dalmolin MC, De Oliveira IB, Barcellos IO (2010) Application of cyclodextrins in textile processes. Quim Nova 33:929–937. https://doi.org/10.1590/S0100-40422010000400031
Antenucci RN, Palmer JK (1984) Enzymic degradation of α- and β-cyclodextrins by bacteroides
of the human colon. J Agric Food Chem 32:1316–1321
N. Morin-Crini et al.
Expensive to produce, the three main native cyclodextrins, i.e., α-, β-, and
γ-cyclodextrins, were long considered just laboratory curiosities. Until the
mid- 1970s, the main obstacles were the lack of sufficient knowledge of these molecules, their high price, and also their presumed toxicity. In addition, very few
researchers were convinced of the industrial potential of cyclodextrins.
As reported in this comprehensive chapter, since Villiers’ discovery, several great
scientists, including Schardinger, Freudenberg, Cramer, French, and Szejtli, have
left their mark on the history, characterization, properties, and potential applications
of these molecules over a period of 86 years, from 1903, i.e., the first paper on
cyclodextrin chemistry published by Schardinger, to 1989, i.e., the creation by
Szejtli of the first company totally devoted to cyclodextrins.
Since the 1980s, cyclodextrins have considerably attracted the interest of scientists and industries in different disciplines including health science, agriculture,
chemistry, biochemistry, and environment. The main reason for this growing interest was their ability to form inclusion complexes with various molecules through
host-guest interactions.
Today, cyclodextrins continue to offer new horizons to scientists and industrials
with a wide range of possible modifications and forms for multiple classical, e.g.,
pharmacy, food industry, chromatography, cosmetology, and biotechnology, and
emerging, e.g., biomedicine, agrochemistry, and nanomaterials, applications.
References
Adeoye O, Figueiredo A, Cabral Marques H (2017) Chapter 13: Cyclodextrins and skin disorders: therapeutic and cosmetic applications. In: Ascenso A, Ribeiro H, Simões S (eds)
Carrier-mediated dermal delivery. Jenny Stanford Publishing, New York, 39 p. https://doi.
org/10.4324/9781315364476
Akiya S, Okui S (1951) Studies of the degeneration process of sugars. 3. Reactions of periodic acid
on 2 hexasaccharides. J Pharm Soc Japan 71:865–869
Akiya S, Watanabe T (1950a) A crystalline decomposition product of starch by a bacillus. 3. A new
strain of Bacillus macerans. J Pharm Soc Japan 70:572–576
Akiya S, Watanabe T (1950b) A crystalline decomposition product of starch by a bacillus. 4. A new
hexasaccharide. J Pharm Soc Japan 70:576–578
Akiya S, Watanabe T (1950c) A crystalline decomposition product of starch by a bacillus. 5.
Structure of the new hexasaccharide. J Pharm Soc Japan 70:579–582
Albers E, Muller BW (1995) Cyclodextrin derivatives in pharmaceutics. Crit Rev Ther Drug
Carrier Syst 12:311–337
Ammayappan L, Moses JJ (2009) An overview on application of cyclodextrins in textile product
enhancement. J Text Assoc 70:9–18
Andersen GH, Robbins FM, Domingues FJ, Moores RG, Long CL (1963) The utilization of
Schardinger dextrins by the rat. Toxicol Appl Pharmacol 5:257–266
Andreaus J, Dalmolin MC, De Oliveira IB, Barcellos IO (2010) Application of cyclodextrins in textile processes. Quim Nova 33:929–937. https://doi.org/10.1590/S0100-40422010000400031
Antenucci RN, Palmer JK (1984) Enzymic degradation of α- and β-cyclodextrins by bacteroides
of the human colon. J Agric Food Chem 32:1316–1321
N. Morin-Crini et al.