31
Cramer 1961; Cramer and Kampe 1962, 1965). For instance, he reported a
cyclodextrin- accelerated reaction studying the hydrolysis of ethyl p- chloromandelate
in the presence of α-cyclodextrin (Cramer and Dietsche 1958). Cyclodextrins can
also be used as an asymmetric agent (Cramer 1961; Cramer and Kampe 1962,
1965). The potential use of cyclodextrins in catalysis and supramolecular chemistry
had been launched. The first reports of their potential use as enzyme models were
also attributed to Cramer. Enzyme-substrate interactions can be established either
by non-covalent bond such as hydrogen bonding or van der Waals forces or by a
covalent bond. When a covalent bond is formed, the cyclodextrin established a
Fig. 1.14 First page of the first patent concerning the applications of cyclodextrin in pharmaceutical formulations filed by Karl Freudenberg, Friedrich Cramer, and Hans Plieninger in 1953
1 History of Cyclodextrins
Cramer 1961; Cramer and Kampe 1962, 1965). For instance, he reported a
cyclodextrin- accelerated reaction studying the hydrolysis of ethyl p- chloromandelate
in the presence of α-cyclodextrin (Cramer and Dietsche 1958). Cyclodextrins can
also be used as an asymmetric agent (Cramer 1961; Cramer and Kampe 1962,
1965). The potential use of cyclodextrins in catalysis and supramolecular chemistry
had been launched. The first reports of their potential use as enzyme models were
also attributed to Cramer. Enzyme-substrate interactions can be established either
by non-covalent bond such as hydrogen bonding or van der Waals forces or by a
covalent bond. When a covalent bond is formed, the cyclodextrin established a
Fig. 1.14 First page of the first patent concerning the applications of cyclodextrin in pharmaceutical formulations filed by Karl Freudenberg, Friedrich Cramer, and Hans Plieninger in 1953
1 History of Cyclodextrins