334
nanopharmaceuticals respectively, they contain a cyclodextrin-containing polymer.
These nanoparticles formulated with a polyethylene glycol steric stabilization
agent, are among the most appropriate nanotherapeutics in clinical phase II trials for
cancer diseases (Weiss et al. 2011; Zuckerman et al. 2014).
There is a flourishing discussion about the inherent advantages, characteristic
features, and potential therapeutic applications of cyclodextrin-based nanoparticles
reported by the scientist fraternity in the past decades to date. These cyclodextrinbased nanoparticles are enriched with various properties of an ideal novel drug
delivery system. Moreover, they overcome the limitations of other carrier systems
as well. Cyclodextrin-based nanoparticles have emerged as a very promising carrier
system for high molecular weight compounds such as peptides, proteins, DNA, and
other genetic materials. Nanoparticles containing cyclodextrins have shown their
potential to improve the loading capacity of carriers such as liposomes, nanoparticles, and solid lipid nanoparticles. This review also highlights the new-generation
cyclodextrin-based nanocarrier for the delivery of associated DNA or proteins with
remarkable cytotoxicity against various cancer cell lines. Amphiphilic cyclodextrins represent unique properties of ideal pharmaceutical excipients, such as the
ability to form nanoparticles spontaneously. Moreover, they possess the advantages
of natural cyclodextrins suitable for drug delivery, together with the advantages of
delivery of drugs through various administration routes such as oral, transdermal,
nasal, ocular, and across the biological membranes including the blood-brain barrier.
References
Agüeros M, Ruiz-Gatón L, Vauthier C, Bouchemal K, Espuelas S, Ponchel G, Irache JM (2009)
Combined hydroxypropyl-β-cyclodextrin and poly(anhydride) nanoparticles improve the
oral permeability of paclitaxel. Eur J Pharm Sci 38:405–413. https://doi.org/10.1016/j.
ejps.2009.09.010
Agüeros M, Espuelas S, Esparza I, Calleja P, Peñuelas I, Ponchel G, Irache JM (2011) Cyclodextrinpoly(anhydride) nanoparticles as new vehicles for oral drug delivery. Expert Opin Drug Deliv
8:721–734. https://doi.org/10.1517/17425247.2011.572069
Ahmed GHG, Laíño RB, Calzón JAG, García MED (2014) Magnetic nanoparticles grafted with
β-cyclodextrin for solid-phase extraction of 5-hydroxy-3-indole acetic acid. Microchim Acta
181:941–948. https://doi.org/10.1007/s00604-014-1192-y
Ammar H, El-Nahhas S, Ghorab M, Salama A (2012) Chitosan/Cyclodextrin nanoparticles as
drug delivery system. J Incl Phenom Macrocycl Chem 72:9950–9955. https://doi.org/10.1007/
s10847-011
Anirudhan TS, Dilu D, Sandeep S (2013) Synthesis and characterisation of chitosan crosslinkedβ- cyclodextrin grafted silylated magnetic nanoparticles for controlled release of Indomethacin.
J Magn Magn Mater 343:149–156. https://doi.org/10.1016/j.jmmm.2013.04.007
Anirudhan TS, Divya PL, Nima J (2015) Synthesis and characterization of silane coated magnetic
nanoparticles/glycidylmethacrylate-grafted-maleated cyclodextrin composite hydrogel as a
drug carrier for the controlled delivery of 5-fluorouracil. Mater Sci Eng C 55:471–481. https://
doi.org/10.1016/j.msec.2015.05.068
Aranda C, Urbiola K, Méndez Ardoy A, García Fernández JM, Ortiz Mellet C, de Ilarduya CT
(2013) Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanoA. Pandey
nanopharmaceuticals respectively, they contain a cyclodextrin-containing polymer.
These nanoparticles formulated with a polyethylene glycol steric stabilization
agent, are among the most appropriate nanotherapeutics in clinical phase II trials for
cancer diseases (Weiss et al. 2011; Zuckerman et al. 2014).
There is a flourishing discussion about the inherent advantages, characteristic
features, and potential therapeutic applications of cyclodextrin-based nanoparticles
reported by the scientist fraternity in the past decades to date. These cyclodextrinbased nanoparticles are enriched with various properties of an ideal novel drug
delivery system. Moreover, they overcome the limitations of other carrier systems
as well. Cyclodextrin-based nanoparticles have emerged as a very promising carrier
system for high molecular weight compounds such as peptides, proteins, DNA, and
other genetic materials. Nanoparticles containing cyclodextrins have shown their
potential to improve the loading capacity of carriers such as liposomes, nanoparticles, and solid lipid nanoparticles. This review also highlights the new-generation
cyclodextrin-based nanocarrier for the delivery of associated DNA or proteins with
remarkable cytotoxicity against various cancer cell lines. Amphiphilic cyclodextrins represent unique properties of ideal pharmaceutical excipients, such as the
ability to form nanoparticles spontaneously. Moreover, they possess the advantages
of natural cyclodextrins suitable for drug delivery, together with the advantages of
delivery of drugs through various administration routes such as oral, transdermal,
nasal, ocular, and across the biological membranes including the blood-brain barrier.
References
Agüeros M, Ruiz-Gatón L, Vauthier C, Bouchemal K, Espuelas S, Ponchel G, Irache JM (2009)
Combined hydroxypropyl-β-cyclodextrin and poly(anhydride) nanoparticles improve the
oral permeability of paclitaxel. Eur J Pharm Sci 38:405–413. https://doi.org/10.1016/j.
ejps.2009.09.010
Agüeros M, Espuelas S, Esparza I, Calleja P, Peñuelas I, Ponchel G, Irache JM (2011) Cyclodextrinpoly(anhydride) nanoparticles as new vehicles for oral drug delivery. Expert Opin Drug Deliv
8:721–734. https://doi.org/10.1517/17425247.2011.572069
Ahmed GHG, Laíño RB, Calzón JAG, García MED (2014) Magnetic nanoparticles grafted with
β-cyclodextrin for solid-phase extraction of 5-hydroxy-3-indole acetic acid. Microchim Acta
181:941–948. https://doi.org/10.1007/s00604-014-1192-y
Ammar H, El-Nahhas S, Ghorab M, Salama A (2012) Chitosan/Cyclodextrin nanoparticles as
drug delivery system. J Incl Phenom Macrocycl Chem 72:9950–9955. https://doi.org/10.1007/
s10847-011
Anirudhan TS, Dilu D, Sandeep S (2013) Synthesis and characterisation of chitosan crosslinkedβ- cyclodextrin grafted silylated magnetic nanoparticles for controlled release of Indomethacin.
J Magn Magn Mater 343:149–156. https://doi.org/10.1016/j.jmmm.2013.04.007
Anirudhan TS, Divya PL, Nima J (2015) Synthesis and characterization of silane coated magnetic
nanoparticles/glycidylmethacrylate-grafted-maleated cyclodextrin composite hydrogel as a
drug carrier for the controlled delivery of 5-fluorouracil. Mater Sci Eng C 55:471–481. https://
doi.org/10.1016/j.msec.2015.05.068
Aranda C, Urbiola K, Méndez Ardoy A, García Fernández JM, Ortiz Mellet C, de Ilarduya CT
(2013) Targeted gene delivery by new folate-polycationic amphiphilic cyclodextrin-DNA nanoA. Pandey