335
complexes in vitro and in vivo. Eur J Pharm Biopharm 85:390–397. https://doi.org/10.1016/j.
ejpb.2013.06.011
Arima H, Hagiwara Y, Hirayama F, Uekama K (2006) Enhancement of antitumor effect of
doxorubicin by its complexation with γ-cyclodextrin in pegylated liposomes. J Drug Target
14:225–232. https://doi.org/10.1080/10611860600711136
Ascenso A, Cruz M, Euletério C, Carvalho FA, Santos NC, Marques HC, Simões S (2013)
Novel tretinoin formulations: a drug-in-cyclodextrin-in-liposome approach. J Liposome Res
23:211–219. https://doi.org/10.3109/08982104.2013.788026
Badruddoza AZM, Rahman MT, Ghosh S, Hossain MZ, Shi J, Hidajat K, Uddin MS (2013)
β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications. Carbohydr Polym 95:449–457. https://doi.org/10.1016/j.carbpol.2013.02.046
Baek JS, Cho CW (2013) 2-Hydroxypropyl-β-cyclodextrin-modified SLN of paclitaxel for overcoming p-glycoprotein function in multidrug-resistant breast cancer cells. J Pharm Pharmacol
65:72–78. https://doi.org/10.1111/j.2042-7158.2012.01578.x
Baek JS, Kim JH, Park JS, Cho CW (2015) Modification of paclitaxel-loaded solid lipid nanoparticles with 2-hydroxypropyl-β-cyclodextrin enhances absorption and reduces nephrotoxicity associated with intravenous injection. Int J Nanomedicine 10:5397–5405. https://doi.
org/10.2147/IJN.S86474
Bakar F, Caglayan M, Onur F, Nebioglu S, Palabiyik I (2015) Gold nanoparticle-lignan complexes
inhibited MCF-7 cell proliferation in vitro: a novel conjugation for cancer therapy. Anticancer
Agents Med Chem 15:336–344. https://doi.org/10.2174/1871520614666141202144152
Banerjee SS, Chen DH (2007) Magnetic nanoparticles grafted with cyclodextrin for hydrophobic
drug delivery. Chem Mater 19:6345–6349. https://doi.org/10.1021/cm702278u
Bilensoy E, Hincal AA (2009) Recent advances and future directions in amphiphilic cyclodextrin nanoparticles. Expert Opin Drug Deliv 6:1161–1173. https://doi.
org/10.1517/17425240903222218
Bilensoy E, Gürkaynak O, Doǧan AL, Hincal AA (2008a) Safety and efficacy of amphiphilic
ß-cyclodextrin nanoparticles for paclitaxel delivery. Int J Pharm 347:163–170. https://doi.
org/10.1016/j.ijpharm.2007.06.051
Bilensoy E, Gürkaynak O, Ertan M, Şen M, Hincal AA (2008b) Development of nonsurfactant
cyclodextrin nanoparticles loaded with anticancer drug paclitaxel. J Pharm Sci 97:1519–1529.
https://doi.org/10.1002/jps.21111
Bragagni M, Maestrelli F, Mura P (2010) Physical chemical characterization of binary systems
of prilocaine hydrochloride with triacetyl-β-cyclodextrin. J Incl Phenom Macrocycl Chem
68:437–445. https://doi.org/10.1007/s10847-010-9807-3
Bu X, Zhu T, Ma Y, Shen Q (2015) Co-administration with cell penetrating peptide enhances
the oral bioavailability of docetaxel-loaded nanoparticles. Drug Dev Ind Pharm 41:764–771.
https://doi.org/10.3109/03639045.2014.902465
Campos EVR, Proença PLF, Oliveira JL, Melville CC, Vechia JFD, De Andrade DJ, Fraceto LF
(2018) Chitosan nanoparticles functionalized with β-cyclodextrin: a promising carrier for
botanical pesticides. Sci Rep 8. https://doi.org/10.1038/s41598-018-20602-y
Carlotti M, Sapino S, Ugazio E, Gallarate M, Morel S (2012) Resveratrol in solid lipid nanoparticles. J Dispers Sci Technol 33:465–471. https://doi.org/10.1080/01932691.2010.548274
Cavalcanti IMF, Mendona EAM, Lira MCB, Honrato SB, Camara CA, Amorim RVS, Filho JM,
Rabello MM, Hernandes MZ, Ayala AP, Santos-Magalhães NS (2011) The encapsulation of
β-lapachone in 2-hydroxypropyl-β-cyclodextrin inclusion complex into liposomes: a physicochemical evaluation and molecular modeling approach. Eur J Pharm Sci 44:332–340. https://
doi.org/10.1016/j.ejps.2011.08.011
Cavalli R, Peira E, Caputo O, Gasco MR (1999) Solid lipid nanoparticles as carriers of hydrocortisone and progesterone complexes with β-cyclodextrins. Int J Pharm 182:59–69. https://doi.
org/10.1016/S0378-5173(99)00066-6
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery
complexes in vitro and in vivo. Eur J Pharm Biopharm 85:390–397. https://doi.org/10.1016/j.
ejpb.2013.06.011
Arima H, Hagiwara Y, Hirayama F, Uekama K (2006) Enhancement of antitumor effect of
doxorubicin by its complexation with γ-cyclodextrin in pegylated liposomes. J Drug Target
14:225–232. https://doi.org/10.1080/10611860600711136
Ascenso A, Cruz M, Euletério C, Carvalho FA, Santos NC, Marques HC, Simões S (2013)
Novel tretinoin formulations: a drug-in-cyclodextrin-in-liposome approach. J Liposome Res
23:211–219. https://doi.org/10.3109/08982104.2013.788026
Badruddoza AZM, Rahman MT, Ghosh S, Hossain MZ, Shi J, Hidajat K, Uddin MS (2013)
β-Cyclodextrin conjugated magnetic, fluorescent silica core-shell nanoparticles for biomedical applications. Carbohydr Polym 95:449–457. https://doi.org/10.1016/j.carbpol.2013.02.046
Baek JS, Cho CW (2013) 2-Hydroxypropyl-β-cyclodextrin-modified SLN of paclitaxel for overcoming p-glycoprotein function in multidrug-resistant breast cancer cells. J Pharm Pharmacol
65:72–78. https://doi.org/10.1111/j.2042-7158.2012.01578.x
Baek JS, Kim JH, Park JS, Cho CW (2015) Modification of paclitaxel-loaded solid lipid nanoparticles with 2-hydroxypropyl-β-cyclodextrin enhances absorption and reduces nephrotoxicity associated with intravenous injection. Int J Nanomedicine 10:5397–5405. https://doi.
org/10.2147/IJN.S86474
Bakar F, Caglayan M, Onur F, Nebioglu S, Palabiyik I (2015) Gold nanoparticle-lignan complexes
inhibited MCF-7 cell proliferation in vitro: a novel conjugation for cancer therapy. Anticancer
Agents Med Chem 15:336–344. https://doi.org/10.2174/1871520614666141202144152
Banerjee SS, Chen DH (2007) Magnetic nanoparticles grafted with cyclodextrin for hydrophobic
drug delivery. Chem Mater 19:6345–6349. https://doi.org/10.1021/cm702278u
Bilensoy E, Hincal AA (2009) Recent advances and future directions in amphiphilic cyclodextrin nanoparticles. Expert Opin Drug Deliv 6:1161–1173. https://doi.
org/10.1517/17425240903222218
Bilensoy E, Gürkaynak O, Doǧan AL, Hincal AA (2008a) Safety and efficacy of amphiphilic
ß-cyclodextrin nanoparticles for paclitaxel delivery. Int J Pharm 347:163–170. https://doi.
org/10.1016/j.ijpharm.2007.06.051
Bilensoy E, Gürkaynak O, Ertan M, Şen M, Hincal AA (2008b) Development of nonsurfactant
cyclodextrin nanoparticles loaded with anticancer drug paclitaxel. J Pharm Sci 97:1519–1529.
https://doi.org/10.1002/jps.21111
Bragagni M, Maestrelli F, Mura P (2010) Physical chemical characterization of binary systems
of prilocaine hydrochloride with triacetyl-β-cyclodextrin. J Incl Phenom Macrocycl Chem
68:437–445. https://doi.org/10.1007/s10847-010-9807-3
Bu X, Zhu T, Ma Y, Shen Q (2015) Co-administration with cell penetrating peptide enhances
the oral bioavailability of docetaxel-loaded nanoparticles. Drug Dev Ind Pharm 41:764–771.
https://doi.org/10.3109/03639045.2014.902465
Campos EVR, Proença PLF, Oliveira JL, Melville CC, Vechia JFD, De Andrade DJ, Fraceto LF
(2018) Chitosan nanoparticles functionalized with β-cyclodextrin: a promising carrier for
botanical pesticides. Sci Rep 8. https://doi.org/10.1038/s41598-018-20602-y
Carlotti M, Sapino S, Ugazio E, Gallarate M, Morel S (2012) Resveratrol in solid lipid nanoparticles. J Dispers Sci Technol 33:465–471. https://doi.org/10.1080/01932691.2010.548274
Cavalcanti IMF, Mendona EAM, Lira MCB, Honrato SB, Camara CA, Amorim RVS, Filho JM,
Rabello MM, Hernandes MZ, Ayala AP, Santos-Magalhães NS (2011) The encapsulation of
β-lapachone in 2-hydroxypropyl-β-cyclodextrin inclusion complex into liposomes: a physicochemical evaluation and molecular modeling approach. Eur J Pharm Sci 44:332–340. https://
doi.org/10.1016/j.ejps.2011.08.011
Cavalli R, Peira E, Caputo O, Gasco MR (1999) Solid lipid nanoparticles as carriers of hydrocortisone and progesterone complexes with β-cyclodextrins. Int J Pharm 182:59–69. https://doi.
org/10.1016/S0378-5173(99)00066-6
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery