333
(2012) formulated nanoparticles of warfarin, an anticoagulant drug, by loading it in
chitosan-cyclodextrin-complexed nanoparticle systems for transdermal drug delivery. The results of in vitro release studies and ex vivo permeation studies of warfarincyclodextrin- complexed nanoparticles paved the new way for the delivery of
hydrophobic drugs. To improve the percutaneous absorption, Kwon and Kim (2010)
fabricated mono-olein cubic phase nanoparticles comprising of 2- hydroxypropyl- b
eta- cyclodextrin, complexed with minoxidil (a vasodilator drug), which were prepared by hydrating molten minoxidil with the inclusion complex solution. The
cubic phase transparent gels were obtained in the presence of pluronic F127 as a
dispersant that showed significant in vitro skin permeability when compared with
native delivery carriers. Econazole nitrate, a poorly soluble antifungal agent for
ocular drug delivery, was developed as the chitosan nanoparticles in the presence of
sulfobutyl-ether-beta-cyclodextrin. Mucoadhesiveness property of chitosan enabled
nanoparticles to interrelate with the ocular mucosa; besides the use of an anionic,
sulfobutyl-ether-beta-cyclodextrin magnified the solubility and delivery of econazole to the cornea (Mahmoud et al. 2011).
Gil et al. (2009) synthesized the novel quaternary ammonium β-cyclodextrin
nanoparticles as drug delivery carriers for doxorubicin to improve the permeability
of doxorubicin, a hydrophobic anticancer drug across the blood-brain barrier. When
quaternary ammonium β-cyclodextrin was experimented in different in vitro studies, it was found to be nontoxic at a concentration of up to 500 mg/ml in bovine
brain microvessel endothelial cells and showed great potential for safe and effective
delivery of doxorubicin and other therapeutic agents across the most complexed
blood-brain barrier. Nanoparticle-based biomedicine has gained enormous acceptance for theranostic applications, due to their advantage features over conventional
therapy. Therefore, in search of a novel theranostic material, Datz et al. (2018) have
synthesized a new β-cyclodextrin-based biocompatible and multifunctional substance that cross-linked with rigid organic linker molecules to yield thermostable,
readily water-dispersible particles having a nanosize range (∼150 nm). In the next
step, these nanoparticles covalently linked with dye molecules to enable effective
tracking of them during in vitro cell experiments. Results showed the successful
nuclei staining with Hoechst 33342 dye, including effective cell killing with the
doxorubicin cargo molecules. Concludingly, these findings represent a promising
approach for the development of novel theranostic systems.
7.10 Conclusion
The application of cyclodextrin-based nanomaterials is beginning to confirm an
effective degree of control in drug delivery and other therapeutic applications,
although their safe, effective, and economical delivery is yet not significantly demonstrated. The chemical modification of cyclodextrin polymers is a promising strategy to extend their pharmaceutical applications. Some nanoparticles, such as
CRLX101 and CALAA-01, are tumor-targeted and siRNA delivery
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery
(2012) formulated nanoparticles of warfarin, an anticoagulant drug, by loading it in
chitosan-cyclodextrin-complexed nanoparticle systems for transdermal drug delivery. The results of in vitro release studies and ex vivo permeation studies of warfarincyclodextrin- complexed nanoparticles paved the new way for the delivery of
hydrophobic drugs. To improve the percutaneous absorption, Kwon and Kim (2010)
fabricated mono-olein cubic phase nanoparticles comprising of 2- hydroxypropyl- b
eta- cyclodextrin, complexed with minoxidil (a vasodilator drug), which were prepared by hydrating molten minoxidil with the inclusion complex solution. The
cubic phase transparent gels were obtained in the presence of pluronic F127 as a
dispersant that showed significant in vitro skin permeability when compared with
native delivery carriers. Econazole nitrate, a poorly soluble antifungal agent for
ocular drug delivery, was developed as the chitosan nanoparticles in the presence of
sulfobutyl-ether-beta-cyclodextrin. Mucoadhesiveness property of chitosan enabled
nanoparticles to interrelate with the ocular mucosa; besides the use of an anionic,
sulfobutyl-ether-beta-cyclodextrin magnified the solubility and delivery of econazole to the cornea (Mahmoud et al. 2011).
Gil et al. (2009) synthesized the novel quaternary ammonium β-cyclodextrin
nanoparticles as drug delivery carriers for doxorubicin to improve the permeability
of doxorubicin, a hydrophobic anticancer drug across the blood-brain barrier. When
quaternary ammonium β-cyclodextrin was experimented in different in vitro studies, it was found to be nontoxic at a concentration of up to 500 mg/ml in bovine
brain microvessel endothelial cells and showed great potential for safe and effective
delivery of doxorubicin and other therapeutic agents across the most complexed
blood-brain barrier. Nanoparticle-based biomedicine has gained enormous acceptance for theranostic applications, due to their advantage features over conventional
therapy. Therefore, in search of a novel theranostic material, Datz et al. (2018) have
synthesized a new β-cyclodextrin-based biocompatible and multifunctional substance that cross-linked with rigid organic linker molecules to yield thermostable,
readily water-dispersible particles having a nanosize range (∼150 nm). In the next
step, these nanoparticles covalently linked with dye molecules to enable effective
tracking of them during in vitro cell experiments. Results showed the successful
nuclei staining with Hoechst 33342 dye, including effective cell killing with the
doxorubicin cargo molecules. Concludingly, these findings represent a promising
approach for the development of novel theranostic systems.
7.10 Conclusion
The application of cyclodextrin-based nanomaterials is beginning to confirm an
effective degree of control in drug delivery and other therapeutic applications,
although their safe, effective, and economical delivery is yet not significantly demonstrated. The chemical modification of cyclodextrin polymers is a promising strategy to extend their pharmaceutical applications. Some nanoparticles, such as
CRLX101 and CALAA-01, are tumor-targeted and siRNA delivery
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery