327
Holzinger et al. (2009) developed a single-walled carbon nanotube with
β-cyclodextrin-functionalized gold nanoparticles attached to the surface, loaded
with polymerized adamantane. The association between the polymerized adamantane and the β-cyclodextrin-functionalized gold nanoparticles ideally simulates the
biological interactions of biotin and avidin. To explore the potential of gold nanoparticles for photothermal release of drug, Sierpe et al. (2015) carried out the synthesis
of a 1:1 β-cyclodextrin-phenylethylamine inclusion complex and the adhesion of
gold nanoparticles onto microcrystals of this complex. Wang et al. (2016a, b)
described an easy method to produce the host-guest assembly of gold nanoparticles
induced by intracellular glutathione. Briefly, gold nanoparticle aggregates were
developed from dispersive gold nanoparticles by host-guest interactions between
ferrocene and β-cyclodextrin and triggered by intracellular glutathione. It is well
known that ferrocene develops an inclusion complex with β-cyclodextrin and
detaches upon ionization (Fc+). Results showed that the synthesized aggregates are
retained for a long time in cancer cells and provoke apoptosis of cells when exposed
to near-infrared irradiation. It has been proven from several scientific investigations
that β-cyclodextrin-functionalized gold nanoparticles are more efficient in anticancer therapy when incorporated with anticancer agents. For example, Ha et al. (2013)
formulated gold nanoparticles decorated with polyethylene glycol and poly
(N-isopropyl acrylamide) linked via complexation between β-cyclodextrin and adamantane groups. It has been observed that exposure of these gold nanoparticles to
low temperature facilitates the release of the doxorubicin as well as transports it
directly to the cancer cell nucleus by dismantling.
Furthermore, Bakar et al. (2015) reported decreased breast cancer cell (MCF-7)
proliferation by complexing various ligands (pinoresinol, lariciresinol, and secoisolariciresinol) with thiolated-β-cyclodextrin and decorating them on the exterior of
gold nanoparticles. Conventional anticancer molecules such as doxorubicin, paclitaxel, and docetaxel were incorporated into the β-cyclodextrin-functionalized gold
nanoparticles and targeted to cancer cells. Findings of cell line studies showed that
the doxorubicin-loaded β-cyclodextrin gold nanoparticles enhanced the cellular
uptake and exerted a significant antiproliferative effect. Similarly, Wang et al. (2016a,
b) constructed a twofold nanoparticulate delivery system based on host- guest nanoplatforms loaded with anticancer agent docetaxel and genetic material siRNA using
gold nanorods coated with polyethylenimine-grafted β-cyclodextrin. The developed
gold nanoparticles, upon exposure to near-infrared laser irradiation, generate a significant hyperthermia effect to trigger siRNA and docetaxel release from the cyclodextrin, and it has been observed that developed gold nanoparticles in combination
with laser irradiation remarkably inhibit lung metastasis of 4T1 breast tumors.
A general method to improve the dispersity of oleic acid-stabilized silver
nanoparticles was proposed by Wang et al. (2016a, b). The authors have modified
the surface properties of the nanoparticles by the configuration of an inclusion complex between surface-bound surfactant particles and α-cyclodextrin. Results showed
that initial cyclodextrin concentration is a key factor responsible for the phase transfer of nanoparticles to the aqueous solutions (Wang et al. 2016a, b). To explore this
concept of phase transfer of silver nanoparticles in aqueous solvents, George et al.
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery
Holzinger et al. (2009) developed a single-walled carbon nanotube with
β-cyclodextrin-functionalized gold nanoparticles attached to the surface, loaded
with polymerized adamantane. The association between the polymerized adamantane and the β-cyclodextrin-functionalized gold nanoparticles ideally simulates the
biological interactions of biotin and avidin. To explore the potential of gold nanoparticles for photothermal release of drug, Sierpe et al. (2015) carried out the synthesis
of a 1:1 β-cyclodextrin-phenylethylamine inclusion complex and the adhesion of
gold nanoparticles onto microcrystals of this complex. Wang et al. (2016a, b)
described an easy method to produce the host-guest assembly of gold nanoparticles
induced by intracellular glutathione. Briefly, gold nanoparticle aggregates were
developed from dispersive gold nanoparticles by host-guest interactions between
ferrocene and β-cyclodextrin and triggered by intracellular glutathione. It is well
known that ferrocene develops an inclusion complex with β-cyclodextrin and
detaches upon ionization (Fc+). Results showed that the synthesized aggregates are
retained for a long time in cancer cells and provoke apoptosis of cells when exposed
to near-infrared irradiation. It has been proven from several scientific investigations
that β-cyclodextrin-functionalized gold nanoparticles are more efficient in anticancer therapy when incorporated with anticancer agents. For example, Ha et al. (2013)
formulated gold nanoparticles decorated with polyethylene glycol and poly
(N-isopropyl acrylamide) linked via complexation between β-cyclodextrin and adamantane groups. It has been observed that exposure of these gold nanoparticles to
low temperature facilitates the release of the doxorubicin as well as transports it
directly to the cancer cell nucleus by dismantling.
Furthermore, Bakar et al. (2015) reported decreased breast cancer cell (MCF-7)
proliferation by complexing various ligands (pinoresinol, lariciresinol, and secoisolariciresinol) with thiolated-β-cyclodextrin and decorating them on the exterior of
gold nanoparticles. Conventional anticancer molecules such as doxorubicin, paclitaxel, and docetaxel were incorporated into the β-cyclodextrin-functionalized gold
nanoparticles and targeted to cancer cells. Findings of cell line studies showed that
the doxorubicin-loaded β-cyclodextrin gold nanoparticles enhanced the cellular
uptake and exerted a significant antiproliferative effect. Similarly, Wang et al. (2016a,
b) constructed a twofold nanoparticulate delivery system based on host- guest nanoplatforms loaded with anticancer agent docetaxel and genetic material siRNA using
gold nanorods coated with polyethylenimine-grafted β-cyclodextrin. The developed
gold nanoparticles, upon exposure to near-infrared laser irradiation, generate a significant hyperthermia effect to trigger siRNA and docetaxel release from the cyclodextrin, and it has been observed that developed gold nanoparticles in combination
with laser irradiation remarkably inhibit lung metastasis of 4T1 breast tumors.
A general method to improve the dispersity of oleic acid-stabilized silver
nanoparticles was proposed by Wang et al. (2016a, b). The authors have modified
the surface properties of the nanoparticles by the configuration of an inclusion complex between surface-bound surfactant particles and α-cyclodextrin. Results showed
that initial cyclodextrin concentration is a key factor responsible for the phase transfer of nanoparticles to the aqueous solutions (Wang et al. 2016a, b). To explore this
concept of phase transfer of silver nanoparticles in aqueous solvents, George et al.
7 Role of Cyclodextrins in Nanoparticle-Based Systems for Drug Delivery