326
molecules to the surface of the gold particles. Two years later, the same authors
developed cyclodextrin-modified gold nanospheres by reduction of AuCl 4 in the
presence of perthiolated cyclodextrin receptors resulting in gold nanospheres modified with attached cyclodextrins. It is proposed that cyclodextrin-modified gold
nanospheres represent multisite hosts in aqueous media. The most common application of cyclodextrin-gold nanoparticles is in biosensor technology.
Table 7.2 Formulations of cyclodextrin-based solid lipid nanoparticles and lipid nanoparticles
loaded with various drugs, utilizing the advantages of both cyclodextrin and nanolipid carriers by
incorporating the drug-cyclodextrin inclusion complex into the lipid nanoparticles
Type of lipid
nanoparticle
Cyclodextrin
Active ingredients
Therapeutic use
Reference
Solid lipid
nanoparticles
2-Hydroxypropylβ-cyclodextrin
Paclitaxel
Anticancer agent
Bake and
Chao (2013)
Solid lipid
nanoparticles
Hydroxypropyl-βcyclodextrin
Indomethacin
Nonsteroidal
anti-inflammatory
drug
Hippalgaonkar
et al. (2013)
Solid lipid
nanoparticles
γ-Cyclodextrin
Stearic acid
Inclusion complex
of stearic acid and
gamma
cyclodextrin
Negi et al.
(2014)
Solid lipid
nanoparticles
2-Hydroxypropylβ-cyclodextrin
Paclitaxel
Anticancer agent
Baek et al.
(2015)
Solid lipid
nanoparticles
Hydroxypropylbeta- cyclodextrin
and
sulfobutyl-etherbeta-cyclodextrin
Hydrochlorothiazide Antihypertensive
and diuretic
Cirri et al.
(2017)
Solid lipid
nanoparticles
Carboxymethyl-βcyclodextrin
Famotidine
H 2 receptor
(antagonistic
effects on gastric
secretion)
Mady et al.
(2010)
Solid lipid
nanoparticles
β-Cyclodextrin
Simvastatin
Antihyperlipidemic Vakhariya
et al. (2017)
Nanostructured
lipid carriers
β-Cyclodextrinepichlorohydrin
polymer
Ketoprofen
Nonsteroidal
anti-inflammatory
drug
Cirri et al.
(2012)
Nanostructured
lipid carriers
Cyclodextrin and
derivatives
Vinpocetine
Protective and
anti-aging agent
Lin et al.
(2014)
Nanostructured
lipid carriers
Methylated-βcyclodextrin
Oxaprozin
Nonsteroidal
anti-inflammatory
drug
Mennini et al.
(2016)
Nanostructured
lipid carriers
Hydroxypropyl-βcyclodextrin and
sulfobutyl-ether-βcyclodextrin
Hydrochlorothiazide Antihypertensive
and diuretic
Cirri et al.
(2018)
Nanostructured
lipid carriers
Hydroxypropyl-βcyclodextrin
Lippia origanoides
(essential oil)
Follicular
accumulation and
controlled delivery
Pires et al.
(2019)
A. Pandey
molecules to the surface of the gold particles. Two years later, the same authors
developed cyclodextrin-modified gold nanospheres by reduction of AuCl 4 in the
presence of perthiolated cyclodextrin receptors resulting in gold nanospheres modified with attached cyclodextrins. It is proposed that cyclodextrin-modified gold
nanospheres represent multisite hosts in aqueous media. The most common application of cyclodextrin-gold nanoparticles is in biosensor technology.
Table 7.2 Formulations of cyclodextrin-based solid lipid nanoparticles and lipid nanoparticles
loaded with various drugs, utilizing the advantages of both cyclodextrin and nanolipid carriers by
incorporating the drug-cyclodextrin inclusion complex into the lipid nanoparticles
Type of lipid
nanoparticle
Cyclodextrin
Active ingredients
Therapeutic use
Reference
Solid lipid
nanoparticles
2-Hydroxypropylβ-cyclodextrin
Paclitaxel
Anticancer agent
Bake and
Chao (2013)
Solid lipid
nanoparticles
Hydroxypropyl-βcyclodextrin
Indomethacin
Nonsteroidal
anti-inflammatory
drug
Hippalgaonkar
et al. (2013)
Solid lipid
nanoparticles
γ-Cyclodextrin
Stearic acid
Inclusion complex
of stearic acid and
gamma
cyclodextrin
Negi et al.
(2014)
Solid lipid
nanoparticles
2-Hydroxypropylβ-cyclodextrin
Paclitaxel
Anticancer agent
Baek et al.
(2015)
Solid lipid
nanoparticles
Hydroxypropylbeta- cyclodextrin
and
sulfobutyl-etherbeta-cyclodextrin
Hydrochlorothiazide Antihypertensive
and diuretic
Cirri et al.
(2017)
Solid lipid
nanoparticles
Carboxymethyl-βcyclodextrin
Famotidine
H 2 receptor
(antagonistic
effects on gastric
secretion)
Mady et al.
(2010)
Solid lipid
nanoparticles
β-Cyclodextrin
Simvastatin
Antihyperlipidemic Vakhariya
et al. (2017)
Nanostructured
lipid carriers
β-Cyclodextrinepichlorohydrin
polymer
Ketoprofen
Nonsteroidal
anti-inflammatory
drug
Cirri et al.
(2012)
Nanostructured
lipid carriers
Cyclodextrin and
derivatives
Vinpocetine
Protective and
anti-aging agent
Lin et al.
(2014)
Nanostructured
lipid carriers
Methylated-βcyclodextrin
Oxaprozin
Nonsteroidal
anti-inflammatory
drug
Mennini et al.
(2016)
Nanostructured
lipid carriers
Hydroxypropyl-βcyclodextrin and
sulfobutyl-ether-βcyclodextrin
Hydrochlorothiazide Antihypertensive
and diuretic
Cirri et al.
(2018)
Nanostructured
lipid carriers
Hydroxypropyl-βcyclodextrin
Lippia origanoides
(essential oil)
Follicular
accumulation and
controlled delivery
Pires et al.
(2019)
A. Pandey