Table 3 Examples of potent bioactive substances produced by alkaliphiles
Alkaliphile
Bioactive
substance
Active against
References
Bacillus halodurans
Haloduricin
(antimicrobial)
Staphylococcus aureus, Enterococcus faecium, Enterococcus
faecalis, Streptococcus sp.,
Pediococcus sp.
Danesh et al.
[152], Lawton et al.
[153]
Bacillus
alkalophilshaggy
JY-827
Aminoglycoside
antibiotic
Streptococcus mutans
Chun et al.
[154]
Streptomyces
sannanensis
Antimicrobial
Gram-positive bacteria such as
Bacillus cereus, B. megaterium,
Staphylococcus aureus
Vasavada
et al. [155]
Streptomyces
tanashiensis
Antifungal
Candida albicans, Fusarium
moniliforme
Singh et al.
[156]
Streptomyces sp.
Antimicrobial
Active against Bacillus subtilis,
Staphylococcus aureus,
Escherichia coli, Proteus vulgaris,
Salmonella typhi
Kharat et al.
[157]
Anticancer
Active against human lung
carcinoma
Kharat et al.
[157]
Streptomyces
aburaviensis
Antimicrobial
Active against Bacillus subtilis,
Staphylococcus aureus,
B. megaterium Bacillus cereus
Thumar et al.
[158]
Nocardiopsis sp.
Naphthospironone
A
Antimicrobial
Bacillus subtilis, Staphylococcus
aureus, Escherichia coli, Aspergillus niger
Ding et al.
[159]
Anticancer
HeLa, L929, AGZY cells
Ding et al.
[159]
Synechocystis
aquatilis
Antimicrobial
Escherichia coli, Staphylococcus
aureus, Proteus vulgaris, Pseudomonas aeruginosa
Deshmukh
and Puranik
[160]
Piscibacillus sp.
Anticancer
Breast cancer MDA-MB-231 cells Neelam et al.
[161]
Streptomyces sp. AK
409
Pyrocoll
Bacteria, filamentous fungi, pathogenic protozoa, and some human
tumor cell lines
Dieter et al.
[162]
Streptomyces
sanglieri AK 623
Lactonamycin Z
Gastric adenocarcinoma cells
Höltzel et al.
[163]
Nocardiopsis sp.
Griseusin D
Human leukemia cells (HL60),
human lung adenocarcinoma cell
lines (AGZY), and fungi
Li et al.
[164]
Streptomyces
violascens
Belongs to polyene
antifungal class
Fungal
Bisht et al.
[165]
Nocardiopsis
alkaliphila
YIM-80379
Nocardiopyrones
A and B
Pseudomonas aeruginosa,
Enterobacter aerogenes, Staphylococcus aureus, and Candida
albicans
Wang et al.
[166]
(continued)
22
G. Mamo and B. Mattiasson
Alkaliphile
Bioactive
substance
Active against
References
Bacillus halodurans
Haloduricin
(antimicrobial)
Staphylococcus aureus, Enterococcus faecium, Enterococcus
faecalis, Streptococcus sp.,
Pediococcus sp.
Danesh et al.
[152], Lawton et al.
[153]
Bacillus
alkalophilshaggy
JY-827
Aminoglycoside
antibiotic
Streptococcus mutans
Chun et al.
[154]
Streptomyces
sannanensis
Antimicrobial
Gram-positive bacteria such as
Bacillus cereus, B. megaterium,
Staphylococcus aureus
Vasavada
et al. [155]
Streptomyces
tanashiensis
Antifungal
Candida albicans, Fusarium
moniliforme
Singh et al.
[156]
Streptomyces sp.
Antimicrobial
Active against Bacillus subtilis,
Staphylococcus aureus,
Escherichia coli, Proteus vulgaris,
Salmonella typhi
Kharat et al.
[157]
Anticancer
Active against human lung
carcinoma
Kharat et al.
[157]
Streptomyces
aburaviensis
Antimicrobial
Active against Bacillus subtilis,
Staphylococcus aureus,
B. megaterium Bacillus cereus
Thumar et al.
[158]
Nocardiopsis sp.
Naphthospironone
A
Antimicrobial
Bacillus subtilis, Staphylococcus
aureus, Escherichia coli, Aspergillus niger
Ding et al.
[159]
Anticancer
HeLa, L929, AGZY cells
Ding et al.
[159]
Synechocystis
aquatilis
Antimicrobial
Escherichia coli, Staphylococcus
aureus, Proteus vulgaris, Pseudomonas aeruginosa
Deshmukh
and Puranik
[160]
Piscibacillus sp.
Anticancer
Breast cancer MDA-MB-231 cells Neelam et al.
[161]
Streptomyces sp. AK
409
Pyrocoll
Bacteria, filamentous fungi, pathogenic protozoa, and some human
tumor cell lines
Dieter et al.
[162]
Streptomyces
sanglieri AK 623
Lactonamycin Z
Gastric adenocarcinoma cells
Höltzel et al.
[163]
Nocardiopsis sp.
Griseusin D
Human leukemia cells (HL60),
human lung adenocarcinoma cell
lines (AGZY), and fungi
Li et al.
[164]
Streptomyces
violascens
Belongs to polyene
antifungal class
Fungal
Bisht et al.
[165]
Nocardiopsis
alkaliphila
YIM-80379
Nocardiopyrones
A and B
Pseudomonas aeruginosa,
Enterobacter aerogenes, Staphylococcus aureus, and Candida
albicans
Wang et al.
[166]
(continued)
22
G. Mamo and B. Mattiasson