80. Tziampazis E, Kohn J, Moghe PV (2000) PEG-variant biomaterials as selectively adhesive
protein templates: model surfaces for controlled cell adhesion and migration. Biomaterials
21:511–520
81. Bourke SL, Kohn J (2003) Polymers derived from the amino acid l-tyrosine: polycarbonates,
polyarylates and copolymers with poly(ethylene glycol). Adv Drug Del Rev 55:447–466
82. Sharma RI, Kohn J, Moghe PV (2004) Poly(ethylene glycol) enhances cell motility on
protein-based poly(ethylene glycol)-polycarbonate substrates: a mechanism for cell-guided
ligand remodeling. J Biomed Mater Res A 69A:114–123
83. Sousa A, Schut J, Kohn J, Libera M (2006) Nanoscale morphological changes during
hydrolytic degradation and erosion of a bioresorbable polymer. Macromolecules
39:7306–7312
84. Kozlowski A, McKannan J, McManus SP (2007) Patent Application PCT/US2006/029,929,
WO/2007/016560A2
85. Won C-Y, Chu C-C, Lee JD (1998) Novel biodegradable copolymers containing pendant
amine functional groups based on aspartic acid and poly(ethylene glycol). Polymer
39:6677–6681
86. Won C-Y, Chu C-C, Lee JD (1998) Synthesis and characterization of biodegradable
poly(L-aspartic acid-co-PEG). J Polym Sci A Polym Chem 36:2949–2959
87. Padmaja T, Lele BS, Deshpande MC, Kulkarni MG (2002) Enzymatically degradable
prodrugs: a novel methodology for drug linkage. J Appl Polym Sci 85:2108–2118
88. Nagahama K, Hashizume M, Yamamoto H, Ouchi T, Ohya Y (2009) Hydrophobically
modified biodegradable poly(ethylene glycol) copolymers that form temperature-responsive
nanogels. Langmuir 25:9734–9740
89. Braunova ´ A, Pechar M, Laga R, Ulbrich K (2007) Hydrolytically and reductively degradable
high-molecular-weight poly(ethylene glycol)s. Macromol Chem Phys 208:2642–2653
90. Harris JM (2001) Patent Application 08/937846, US06,214,966B1
91. Nagata M, Hizakae S (2003) Synthesis and properties of biodegradable copolymers based on
4,4
0 -(adipoyldioxy)dicinnamic acid, 1,6-hexanediol, and poly(ethylene glycol)s. J Polym Sci
A Polym Chem 41:2930–2938
92. Nagata M, Hizakae S (2003) Synthesis and characterization of photocrosslinkable biodegradable polymers derived from 4-hydroxycinnamic acid. Macromol Biosci 3:412–419
93. Mero A, Schiavon O, Pasut G, Veronese FM, Emilitri E, Ferruti P (2009) A biodegradable
polymeric carrier based on PEG for drug delivery. J Bioact Compat Polym 24:220–234
94. Unal S, Lin Q, Mourey TH, Long TE (2005) Tailoring the degree of branching: preparation of
poly(ether ester)s via copolymerization of poly(ethylene glycol) oligomers (A2) and 1,3,5benzenetricarbonyl trichloride (B3). Macromolecules 38:3246–3254
95. Wang N, Dong A, Tang H, Van Kirk EA, Johnson PA, Murdoch WJ, Radosz M, Shen Y
(2007) Synthesis of degradable functional poly(ethylene glycol) analogs as versatile drug
delivery carriers. Macromol Biosci 7:1187–1198
96. Wang N, Dong A, Radosz M, Shen Y (2008) Thermoresponsive degradable poly(ethylene
glycol) analogues. J Biomed Mater Res A 84A:148–157
97. Chen S, Wang Y, Fan Y, Ma J (2009) Synthesis of amphiphilic poly(tetraethylene glycol
succinate) and the thermosensitivity of its aggregation in water. J Biomed Mater Res A
88A:769–777
98. Kumar R, Chen M-H, Parmar VS, Samuelson LA, Kumar J, Nicolosi R, Yoganathan S,
Watterson AC (2004) Supramolecular assemblies based on copolymers of PEG600 and
functionalized aromatic diesters for drug delivery applications. J Am Chem Soc
126:10640–10644
99. Dou S, Zhang S, Klein RJ, Runt J, Colby RH (2006) Synthesis and characterization of poly
(ethylene glycol)-based single-ion conductors. Chem Mater 18:4288–4295
100. Wang W, Liu W, Tudryn GJ, Colby RH, Winey KI (2010) Multi-length scale morphology of
poly(ethylene oxide)-based sulfonate ionomers with alkali cations at room temperature.
Macromolecules 43:4223–4229
From Biocompatible to Biodegradable: Poly(Ethylene Glycol)s with. . .
187
protein templates: model surfaces for controlled cell adhesion and migration. Biomaterials
21:511–520
81. Bourke SL, Kohn J (2003) Polymers derived from the amino acid l-tyrosine: polycarbonates,
polyarylates and copolymers with poly(ethylene glycol). Adv Drug Del Rev 55:447–466
82. Sharma RI, Kohn J, Moghe PV (2004) Poly(ethylene glycol) enhances cell motility on
protein-based poly(ethylene glycol)-polycarbonate substrates: a mechanism for cell-guided
ligand remodeling. J Biomed Mater Res A 69A:114–123
83. Sousa A, Schut J, Kohn J, Libera M (2006) Nanoscale morphological changes during
hydrolytic degradation and erosion of a bioresorbable polymer. Macromolecules
39:7306–7312
84. Kozlowski A, McKannan J, McManus SP (2007) Patent Application PCT/US2006/029,929,
WO/2007/016560A2
85. Won C-Y, Chu C-C, Lee JD (1998) Novel biodegradable copolymers containing pendant
amine functional groups based on aspartic acid and poly(ethylene glycol). Polymer
39:6677–6681
86. Won C-Y, Chu C-C, Lee JD (1998) Synthesis and characterization of biodegradable
poly(L-aspartic acid-co-PEG). J Polym Sci A Polym Chem 36:2949–2959
87. Padmaja T, Lele BS, Deshpande MC, Kulkarni MG (2002) Enzymatically degradable
prodrugs: a novel methodology for drug linkage. J Appl Polym Sci 85:2108–2118
88. Nagahama K, Hashizume M, Yamamoto H, Ouchi T, Ohya Y (2009) Hydrophobically
modified biodegradable poly(ethylene glycol) copolymers that form temperature-responsive
nanogels. Langmuir 25:9734–9740
89. Braunova ´ A, Pechar M, Laga R, Ulbrich K (2007) Hydrolytically and reductively degradable
high-molecular-weight poly(ethylene glycol)s. Macromol Chem Phys 208:2642–2653
90. Harris JM (2001) Patent Application 08/937846, US06,214,966B1
91. Nagata M, Hizakae S (2003) Synthesis and properties of biodegradable copolymers based on
4,4
0 -(adipoyldioxy)dicinnamic acid, 1,6-hexanediol, and poly(ethylene glycol)s. J Polym Sci
A Polym Chem 41:2930–2938
92. Nagata M, Hizakae S (2003) Synthesis and characterization of photocrosslinkable biodegradable polymers derived from 4-hydroxycinnamic acid. Macromol Biosci 3:412–419
93. Mero A, Schiavon O, Pasut G, Veronese FM, Emilitri E, Ferruti P (2009) A biodegradable
polymeric carrier based on PEG for drug delivery. J Bioact Compat Polym 24:220–234
94. Unal S, Lin Q, Mourey TH, Long TE (2005) Tailoring the degree of branching: preparation of
poly(ether ester)s via copolymerization of poly(ethylene glycol) oligomers (A2) and 1,3,5benzenetricarbonyl trichloride (B3). Macromolecules 38:3246–3254
95. Wang N, Dong A, Tang H, Van Kirk EA, Johnson PA, Murdoch WJ, Radosz M, Shen Y
(2007) Synthesis of degradable functional poly(ethylene glycol) analogs as versatile drug
delivery carriers. Macromol Biosci 7:1187–1198
96. Wang N, Dong A, Radosz M, Shen Y (2008) Thermoresponsive degradable poly(ethylene
glycol) analogues. J Biomed Mater Res A 84A:148–157
97. Chen S, Wang Y, Fan Y, Ma J (2009) Synthesis of amphiphilic poly(tetraethylene glycol
succinate) and the thermosensitivity of its aggregation in water. J Biomed Mater Res A
88A:769–777
98. Kumar R, Chen M-H, Parmar VS, Samuelson LA, Kumar J, Nicolosi R, Yoganathan S,
Watterson AC (2004) Supramolecular assemblies based on copolymers of PEG600 and
functionalized aromatic diesters for drug delivery applications. J Am Chem Soc
126:10640–10644
99. Dou S, Zhang S, Klein RJ, Runt J, Colby RH (2006) Synthesis and characterization of poly
(ethylene glycol)-based single-ion conductors. Chem Mater 18:4288–4295
100. Wang W, Liu W, Tudryn GJ, Colby RH, Winey KI (2010) Multi-length scale morphology of
poly(ethylene oxide)-based sulfonate ionomers with alkali cations at room temperature.
Macromolecules 43:4223–4229
From Biocompatible to Biodegradable: Poly(Ethylene Glycol)s with. . .
187