60. Cui W, Qi M, Li X, Huang S, Zhou S, Weng J (2008) Electrospun fibers of acid-labile
biodegradable polymers with acetal groups as potential drug carriers. Int J Pharm 361:47–55
61. Wong JB, Grosse S, Tabor AB, Hart SL, Hailes HC (2008) Acid cleavable PEG-lipids for
applications in a ternary gene delivery vector. Mol BioSyst 4:532–541
62. Betz MW, Caccamese JF, Coletti DP, Sauk JJ, Fisher JP (2009) Tissue response and orbital
floor regeneration using cyclic acetal hydrogels. J Biomed Mater Res A 90A:819–829
63. Kaihara S, Matsumura S, Fisher JP (2009) Cellular responses to degradable cyclic acetal
modified PEG hydrogels. J Biomed Mater Res A 90A:863–873
64. Kaihara S, Fisher JP, Matsumura S (2009) Chemo-enzymatic synthesis of degradable PTMCb-PECA-b-PTMC triblock copolymers and their micelle formation for pH-dependent controlled release. Macromol Biosci 9:613–621
65. Wang Y, Morinaga H, Sudo A, Endo T (2011) Synthesis of amphiphilic polyacetal by
polycondensation of aldehyde and polyethylene glycol as an acid-labile polymer for controlled release of aldehyde. J Polym Sci A Polym Chem 49:596–602
66. England RM, Masia ´ E, Gime ´nez V, Lucas R, Vicent MJ (2012) Polyacetal-stilbene
conjugates – the first examples of polymer therapeutics for the inhibition of HIF-1 in the
treatment of solid tumours. J Contr Release 164:314–322
67. Gime ´nez V, James C, Armina ´n A, Schweins R, Paul A, Vicent MJ (2012) Demonstrating the
importance of polymer-conjugate conformation in solution on its therapeutic output: diethylstilbestrol (DES)-polyacetals as prostate cancer treatment. J Contr Release 159:290–301
68. Tonhauser C, Schu ¨ll C, Dingels C, Frey H (2012) Branched acid-degradable, biocompatible
polyether copolymers via anionic ring-opening polymerization using an epoxide inimer. ACS
Macro Lett 1:1094–1097
69. Feng X, Chaikof EL, Absalon C, Drummond C, Taton D, Gnanou Y (2011) Dendritic carrier
based on PEG: design and degradation of acid-sensitive dendrimer-like poly(ethylene oxide)s.
Macromol Rapid Commun 32:1722–1728
70. Dingels C, Mu ¨ller SS, Steinbach T, Tonhauser C, Frey H (2013) Universal concept for the
implemantation of a single cleavable unit at tunable position in functional poly(ethylene
glycol)s. Biomacromolecules 14:448–459
71. DuBois Clochard M-C, Rankin S, Brocchini S (2000) Synthesis of soluble polymers for
medicine that degrade by intramolecular acid catalysis. Macromol Rapid Commun
21:853–859
72. Lai J, Wang L-Q, Tu K, Zhao C, Sun W (2005) Linear azo polymer containing conjugated
5,5
0 -azodisalicylic acid segments in the main chain: synthesis, characterization, and degradation. Macromol Rapid Commun 26:1572–1577
73. Lai J, Tu K, Wang H, Chen Z, Wang L-Q (2008) Degradability of the linear azo polymer
conjugated 5,5
0 -azodisalicylic acid segment in the main chain for colon-specific drug delivery. J Appl Polym Sci 108:3305–3312
74. Goldberg EP (1963) Elastomeric polycarbonate block copolymers. J Polym Sci C Polym
Symp 4:707–730
75. Suzuki T, Kotaka T (1980) Dielectric and mechanical relaxations in randomly coupled
multiblock copolymers with varying block lengths: bisphenol-A polycarbonate-poly
(oxyethylene) systems. Macromolecules 13:1495–1501
76. Suzuki T, Kotaka T (1983) Morphological and physical properties of randomly coupled
multiblock copolymers: bisphenol-A polycarbonate-poply(oxyethylene) systems. Polym J
15:15–23
77. Suzuki T, Chihara H, Kotaka T (1984) Sorption of water by bisphenol-A polycarbonate and
polyoxyethylene multiblock copolymers with varying composition and block length. Polym J
16:129–138
78. Tanisugi H, Ohnuma H, Kotaka T (1984) Swelling behavior of bisphenol-A polycarbonatepolyoxyethylene multiblock copolymers in ethanol/water mixtures. Polym J 16:633–640
79. Harris JM, Bentley MD, Zhoa X, Shen X (2002) Patent Application 09/459312,
US6,348,558B1
186
C. Dingels and H. Frey
biodegradable polymers with acetal groups as potential drug carriers. Int J Pharm 361:47–55
61. Wong JB, Grosse S, Tabor AB, Hart SL, Hailes HC (2008) Acid cleavable PEG-lipids for
applications in a ternary gene delivery vector. Mol BioSyst 4:532–541
62. Betz MW, Caccamese JF, Coletti DP, Sauk JJ, Fisher JP (2009) Tissue response and orbital
floor regeneration using cyclic acetal hydrogels. J Biomed Mater Res A 90A:819–829
63. Kaihara S, Matsumura S, Fisher JP (2009) Cellular responses to degradable cyclic acetal
modified PEG hydrogels. J Biomed Mater Res A 90A:863–873
64. Kaihara S, Fisher JP, Matsumura S (2009) Chemo-enzymatic synthesis of degradable PTMCb-PECA-b-PTMC triblock copolymers and their micelle formation for pH-dependent controlled release. Macromol Biosci 9:613–621
65. Wang Y, Morinaga H, Sudo A, Endo T (2011) Synthesis of amphiphilic polyacetal by
polycondensation of aldehyde and polyethylene glycol as an acid-labile polymer for controlled release of aldehyde. J Polym Sci A Polym Chem 49:596–602
66. England RM, Masia ´ E, Gime ´nez V, Lucas R, Vicent MJ (2012) Polyacetal-stilbene
conjugates – the first examples of polymer therapeutics for the inhibition of HIF-1 in the
treatment of solid tumours. J Contr Release 164:314–322
67. Gime ´nez V, James C, Armina ´n A, Schweins R, Paul A, Vicent MJ (2012) Demonstrating the
importance of polymer-conjugate conformation in solution on its therapeutic output: diethylstilbestrol (DES)-polyacetals as prostate cancer treatment. J Contr Release 159:290–301
68. Tonhauser C, Schu ¨ll C, Dingels C, Frey H (2012) Branched acid-degradable, biocompatible
polyether copolymers via anionic ring-opening polymerization using an epoxide inimer. ACS
Macro Lett 1:1094–1097
69. Feng X, Chaikof EL, Absalon C, Drummond C, Taton D, Gnanou Y (2011) Dendritic carrier
based on PEG: design and degradation of acid-sensitive dendrimer-like poly(ethylene oxide)s.
Macromol Rapid Commun 32:1722–1728
70. Dingels C, Mu ¨ller SS, Steinbach T, Tonhauser C, Frey H (2013) Universal concept for the
implemantation of a single cleavable unit at tunable position in functional poly(ethylene
glycol)s. Biomacromolecules 14:448–459
71. DuBois Clochard M-C, Rankin S, Brocchini S (2000) Synthesis of soluble polymers for
medicine that degrade by intramolecular acid catalysis. Macromol Rapid Commun
21:853–859
72. Lai J, Wang L-Q, Tu K, Zhao C, Sun W (2005) Linear azo polymer containing conjugated
5,5
0 -azodisalicylic acid segments in the main chain: synthesis, characterization, and degradation. Macromol Rapid Commun 26:1572–1577
73. Lai J, Tu K, Wang H, Chen Z, Wang L-Q (2008) Degradability of the linear azo polymer
conjugated 5,5
0 -azodisalicylic acid segment in the main chain for colon-specific drug delivery. J Appl Polym Sci 108:3305–3312
74. Goldberg EP (1963) Elastomeric polycarbonate block copolymers. J Polym Sci C Polym
Symp 4:707–730
75. Suzuki T, Kotaka T (1980) Dielectric and mechanical relaxations in randomly coupled
multiblock copolymers with varying block lengths: bisphenol-A polycarbonate-poly
(oxyethylene) systems. Macromolecules 13:1495–1501
76. Suzuki T, Kotaka T (1983) Morphological and physical properties of randomly coupled
multiblock copolymers: bisphenol-A polycarbonate-poply(oxyethylene) systems. Polym J
15:15–23
77. Suzuki T, Chihara H, Kotaka T (1984) Sorption of water by bisphenol-A polycarbonate and
polyoxyethylene multiblock copolymers with varying composition and block length. Polym J
16:129–138
78. Tanisugi H, Ohnuma H, Kotaka T (1984) Swelling behavior of bisphenol-A polycarbonatepolyoxyethylene multiblock copolymers in ethanol/water mixtures. Polym J 16:633–640
79. Harris JM, Bentley MD, Zhoa X, Shen X (2002) Patent Application 09/459312,
US6,348,558B1
186
C. Dingels and H. Frey