37. Gao L, Nie L, Wang T et al (2006) Carbon nanotube delivery of the GFP gene into
mammalian cells. Chembiochem 7:239–242
38. Mann DG, McKnight TE, McPherson JT et al (2008) Inducible RNA interference-mediated
gene silencing using nanostructured gene delivery arrays. ACS Nano 2:69–76
39. Yu Z, McKnight TE, Ericson MN et al (2012) Vertically aligned carbon nanofiber as nanoneuron interface for monitoring neural function. Nanomedicine 8:419–423
40. Boussif O, Lezoualc’h F, Zanta MA et al (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA
92:7297–7301
41. Gosselin MA, Guo W, Lee RJ (2001) Efficient gene transfer using reversibly cross-linked low
molecular weight polyethylenimine. Bioconjug Chem 12:989–994
42. Neu M, Sitterberg J, Bakowsky U et al (2006) Stabilized nanocarriers for plasmids based
upon cross-linked poly(ethylene imine). Biomacromolecules 7:3428–3438
43. Sun YX, Zeng X, Meng QF et al (2008) The influence of RGD addition on the gene transfer
characteristics of disulfide-containing polyethyleneimine/DNA complexes. Biomaterials
29:4356–4365
44. Peng Q, Zhong Z, Zhuo R (2008) Disulfide cross-linked polyethylenimines (PEI) prepared
via thiolation of low molecular weight PEI as highly efficient gene vectors. Bioconjug Chem
19:499–506
45. Breunig M, Lungwitz U, Liebl R et al (2007) Breaking up the correlation between efficacy
and toxicity for nonviral gene delivery. Proc Natl Acad Sci USA 104:14454–14459
46. Lee Y, Mo H, Koo H et al (2007) Visualization of the degradation of a disulfide polymer,
linear poly(ethylenimine sulfide), for gene delivery. Bioconjug Chem 18:13–18
47. Koo H, Jin GW, Kang H et al (2010) Biodegradable branched poly(ethylenimine sulfide) for
gene delivery. Biomaterials 31:988–997
48. Hosseinkhani H, Hosseinkhani M, Gabrielson NP et al (2008) DNA nanoparticles
encapsulated in 3D tissue-engineered scaffolds enhance osteogenic differentiation of mesenchymal stem cells. J Biomed Mater Res A 85:47–60
49. Neu M, Germershaus O, Behe M et al (2007) Bioreversibly crosslinked polyplexes of PEI and
high molecular weight PEG show extended circulation times in vivo. J Control Release
124:69–80
50. Ahn CH, Chae SY, Bae YH et al (2002) Biodegradable poly(ethylenimine) for plasmid DNA
delivery. J Control Release 80:273–282
51. Chen XA, Zhang LJ, He ZJ et al (2011) Plasmid-encapsulated polyethylene glycol-grafted
polyethylenimine nanoparticles for gene delivery into rat mesenchymal stem cells. Int J
Nanomedicine 6:843–853
52. Mahor S, Collin E, Dash BC et al (2011) Controlled release of plasmid DNA from hyaluronan
nanoparticles. Curr Drug Deliv 8:354–362
53. Park JS, Na K, Woo DG et al (2010) Non-viral gene delivery of DNA polyplexed with
nanoparticles transfected into human mesenchymal stem cells. Biomaterials 31:124–132
54. Jeon SY, Park JS, Yang HN et al (2012) Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA
coated onto PLGA nanoparticles for chondrogenesis of human MSCs. Biomaterials 33
(17):4413–4423
55. Pimpha N, Sunintaboon P, Inphonlek S et al (2010) Gene delivery efficacy of
polyethyleneimine-introduced chitosan shell/poly(methyl methacrylate) core nanoparticles
for rat mesenchymal stem cells. J Biomater Sci Polym Ed 21:205–223
56. Park JS, Yang HN, Woo DG et al (2011) Chondrogenesis of human mesenchymal stem cells
mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEImodified PLGA nanoparticles. Biomaterials 32:3679–3688
57. Kakizawa Y, Harada A, Kataoka K (2001) Glutathione-sensitive stabilization of block
copolymer micelles composed of antisense DNA and thiolated poly(ethylene glycol)-blockpoly(L-lysine): a potential carrier for systemic delivery of antisense DNA. Biomacromolecules 2:491–497
80
P. Pushp et al.
mammalian cells. Chembiochem 7:239–242
38. Mann DG, McKnight TE, McPherson JT et al (2008) Inducible RNA interference-mediated
gene silencing using nanostructured gene delivery arrays. ACS Nano 2:69–76
39. Yu Z, McKnight TE, Ericson MN et al (2012) Vertically aligned carbon nanofiber as nanoneuron interface for monitoring neural function. Nanomedicine 8:419–423
40. Boussif O, Lezoualc’h F, Zanta MA et al (1995) A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA
92:7297–7301
41. Gosselin MA, Guo W, Lee RJ (2001) Efficient gene transfer using reversibly cross-linked low
molecular weight polyethylenimine. Bioconjug Chem 12:989–994
42. Neu M, Sitterberg J, Bakowsky U et al (2006) Stabilized nanocarriers for plasmids based
upon cross-linked poly(ethylene imine). Biomacromolecules 7:3428–3438
43. Sun YX, Zeng X, Meng QF et al (2008) The influence of RGD addition on the gene transfer
characteristics of disulfide-containing polyethyleneimine/DNA complexes. Biomaterials
29:4356–4365
44. Peng Q, Zhong Z, Zhuo R (2008) Disulfide cross-linked polyethylenimines (PEI) prepared
via thiolation of low molecular weight PEI as highly efficient gene vectors. Bioconjug Chem
19:499–506
45. Breunig M, Lungwitz U, Liebl R et al (2007) Breaking up the correlation between efficacy
and toxicity for nonviral gene delivery. Proc Natl Acad Sci USA 104:14454–14459
46. Lee Y, Mo H, Koo H et al (2007) Visualization of the degradation of a disulfide polymer,
linear poly(ethylenimine sulfide), for gene delivery. Bioconjug Chem 18:13–18
47. Koo H, Jin GW, Kang H et al (2010) Biodegradable branched poly(ethylenimine sulfide) for
gene delivery. Biomaterials 31:988–997
48. Hosseinkhani H, Hosseinkhani M, Gabrielson NP et al (2008) DNA nanoparticles
encapsulated in 3D tissue-engineered scaffolds enhance osteogenic differentiation of mesenchymal stem cells. J Biomed Mater Res A 85:47–60
49. Neu M, Germershaus O, Behe M et al (2007) Bioreversibly crosslinked polyplexes of PEI and
high molecular weight PEG show extended circulation times in vivo. J Control Release
124:69–80
50. Ahn CH, Chae SY, Bae YH et al (2002) Biodegradable poly(ethylenimine) for plasmid DNA
delivery. J Control Release 80:273–282
51. Chen XA, Zhang LJ, He ZJ et al (2011) Plasmid-encapsulated polyethylene glycol-grafted
polyethylenimine nanoparticles for gene delivery into rat mesenchymal stem cells. Int J
Nanomedicine 6:843–853
52. Mahor S, Collin E, Dash BC et al (2011) Controlled release of plasmid DNA from hyaluronan
nanoparticles. Curr Drug Deliv 8:354–362
53. Park JS, Na K, Woo DG et al (2010) Non-viral gene delivery of DNA polyplexed with
nanoparticles transfected into human mesenchymal stem cells. Biomaterials 31:124–132
54. Jeon SY, Park JS, Yang HN et al (2012) Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA
coated onto PLGA nanoparticles for chondrogenesis of human MSCs. Biomaterials 33
(17):4413–4423
55. Pimpha N, Sunintaboon P, Inphonlek S et al (2010) Gene delivery efficacy of
polyethyleneimine-introduced chitosan shell/poly(methyl methacrylate) core nanoparticles
for rat mesenchymal stem cells. J Biomater Sci Polym Ed 21:205–223
56. Park JS, Yang HN, Woo DG et al (2011) Chondrogenesis of human mesenchymal stem cells
mediated by the combination of SOX trio SOX5, 6, and 9 genes complexed with PEImodified PLGA nanoparticles. Biomaterials 32:3679–3688
57. Kakizawa Y, Harada A, Kataoka K (2001) Glutathione-sensitive stabilization of block
copolymer micelles composed of antisense DNA and thiolated poly(ethylene glycol)-blockpoly(L-lysine): a potential carrier for systemic delivery of antisense DNA. Biomacromolecules 2:491–497
80
P. Pushp et al.