14. Hackenberg S, Scherzed A, Kessler M et al (2011) Silver nanoparticles: evaluation of DNA
damage, toxicity and functional impairment in human mesenchymal stem cells. Toxicol Lett
201:27–33
15. Niidome Y, Niidome T, Yamada S et al (2006) Pulsed-laser induced fragmentation and
dissociation of DNA immobilized on gold nanoparticles. Mol Cryst Liq Cryst 445:201–206
16. Chen CC, Lin YP, Wang CW et al (2006) DNA-gold nanorod conjugates for remote control
of localized gene expression by near infrared irradiation. J Am Chem Soc 128:3709–3715
17. Takahashi H, Niidome Y, Yamada S (2005) Controlled release of plasmid DNA from gold
nanorods induced by pulsed near-infrared light. Chem Commun (Camb) 2247–2249
18. Wijaya A, Schaffer SB, Pallares IG et al (2009) Selective release of multiple DNA
oligonucleotides from gold nanorods. ACS Nano 3:80–86
19. Kawano T, Yamagata M, Takahashi H et al (2006) Stabilizing of plasmid DNA in vivo by
PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical
pulses. J Control Release 111:382–389
20. Huang YF, Sefah K, Bamrungsap S et al (2008) Selective photothermal therapy for mixed
cancer cells using aptamer-conjugated nanorods. Langmuir 24:11860–11865
21. Boyer C, Priyanto P, Davis TP et al (2010) Anti-fouling magnetic nanoparticles for siRNA
delivery. J Mater Chem 20:255–265
22. Kamau SW, Hassa PO, Steitz B et al (2006) Enhancement of the efficiency of non-viral gene
delivery by application of pulsed magnetic field. Nucleic Acids Res 34:e40
23. McBain SC, Griesenbach U, Xenariou S et al (2008) Magnetic nanoparticles as gene delivery
agents: enhanced transfection in the presence of oscillating magnet arrays. Nanotechnology
19:405102
24. Ito A, Shinkai M, Honda H et al (2001) Heat-inducible TNF-alpha gene therapy combined
with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy. Cancer
Gene Ther 8:649–654
25. Tang QS, Zhang DS, Cong XM et al (2008) Using thermal energy produced by irradiation of
Mn–Zn ferrite magnetic nanoparticles (MZF-NPs) for heat-inducible gene expression.
Biomaterials 29:2673–2679
26. Kami D, Takeda S, Itakura Y et al (2011) Application of magnetic nanoparticles to gene
delivery. Int J Mol Sci 12:3705–3722
27. Huth S, Lausier J, Gersting SW et al (2004) Insights into the mechanism of magnetofection
using PEI-based magnetofectins for gene transfer. J Gene Med 6:923–936
28. Bharali DJ, Klejbor I, Stachowiak EK et al (2005) Organically modified silica nanoparticles:
a nonviral vector for in vivo gene delivery and expression in the brain. Proc Natl Acad Sci
USA 102:11539–11544
29. Gemeinhart RA, Luo D, Saltzman WM (2005) Cellular fate of a modular DNA delivery
system mediated by silica nanoparticles. Biotechnol Prog 21:532–537
30. Li Z, Zhu S, Gan K et al (2005) Poly-L-lysine-modified silica nanoparticles: a potential oral
gene delivery system. J Nanosci Nanotechnol 5:1199–1203
31. Radu DR, Lai CY, Jeftinija K et al (2004) A polyamidoamine dendrimer-capped mesoporous
silica nanosphere-based gene transfection reagent. J Am Chem Soc 126:13216–13217
32. Kim W, Ng JK, Kunitake ME et al (2007) Interfacing silicon nanowires with mammalian
cells. J Am Chem Soc 129:7228–7229
33. Roy I, Ohulchanskyy TY, Bharali DJ, Pudavar HE, Mistretta RA, Kaur N, Prasa PN (2005)
Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral,
nanomedicine approach for gene delivery. Proc Natl Acad Sci USA 102:279–284
34. Chang JS, Chang KL, Hwang DF et al (2007) In vitro cytotoxicitiy of silica nanoparticles at
high concentrations strongly depends on the metabolic activity type of the cell line. Environ
Sci Technol 41:2064–2068
35. Lin W, Huang YW, Zhou XD et al (2006) In vitro toxicity of silica nanoparticles in human
lung cancer cells. Toxicol Appl Pharmacol 217:252–259
36. Cai D, Mataraza JM, Qin ZH et al (2005) Highly efficient molecular delivery into mammalian
cells using carbon nanotube spearing. Nat Methods 2:449–454
Nanoparticles for Gene Delivery into Stem Cells and Embryos
79
damage, toxicity and functional impairment in human mesenchymal stem cells. Toxicol Lett
201:27–33
15. Niidome Y, Niidome T, Yamada S et al (2006) Pulsed-laser induced fragmentation and
dissociation of DNA immobilized on gold nanoparticles. Mol Cryst Liq Cryst 445:201–206
16. Chen CC, Lin YP, Wang CW et al (2006) DNA-gold nanorod conjugates for remote control
of localized gene expression by near infrared irradiation. J Am Chem Soc 128:3709–3715
17. Takahashi H, Niidome Y, Yamada S (2005) Controlled release of plasmid DNA from gold
nanorods induced by pulsed near-infrared light. Chem Commun (Camb) 2247–2249
18. Wijaya A, Schaffer SB, Pallares IG et al (2009) Selective release of multiple DNA
oligonucleotides from gold nanorods. ACS Nano 3:80–86
19. Kawano T, Yamagata M, Takahashi H et al (2006) Stabilizing of plasmid DNA in vivo by
PEG-modified cationic gold nanoparticles and the gene expression assisted with electrical
pulses. J Control Release 111:382–389
20. Huang YF, Sefah K, Bamrungsap S et al (2008) Selective photothermal therapy for mixed
cancer cells using aptamer-conjugated nanorods. Langmuir 24:11860–11865
21. Boyer C, Priyanto P, Davis TP et al (2010) Anti-fouling magnetic nanoparticles for siRNA
delivery. J Mater Chem 20:255–265
22. Kamau SW, Hassa PO, Steitz B et al (2006) Enhancement of the efficiency of non-viral gene
delivery by application of pulsed magnetic field. Nucleic Acids Res 34:e40
23. McBain SC, Griesenbach U, Xenariou S et al (2008) Magnetic nanoparticles as gene delivery
agents: enhanced transfection in the presence of oscillating magnet arrays. Nanotechnology
19:405102
24. Ito A, Shinkai M, Honda H et al (2001) Heat-inducible TNF-alpha gene therapy combined
with hyperthermia using magnetic nanoparticles as a novel tumor-targeted therapy. Cancer
Gene Ther 8:649–654
25. Tang QS, Zhang DS, Cong XM et al (2008) Using thermal energy produced by irradiation of
Mn–Zn ferrite magnetic nanoparticles (MZF-NPs) for heat-inducible gene expression.
Biomaterials 29:2673–2679
26. Kami D, Takeda S, Itakura Y et al (2011) Application of magnetic nanoparticles to gene
delivery. Int J Mol Sci 12:3705–3722
27. Huth S, Lausier J, Gersting SW et al (2004) Insights into the mechanism of magnetofection
using PEI-based magnetofectins for gene transfer. J Gene Med 6:923–936
28. Bharali DJ, Klejbor I, Stachowiak EK et al (2005) Organically modified silica nanoparticles:
a nonviral vector for in vivo gene delivery and expression in the brain. Proc Natl Acad Sci
USA 102:11539–11544
29. Gemeinhart RA, Luo D, Saltzman WM (2005) Cellular fate of a modular DNA delivery
system mediated by silica nanoparticles. Biotechnol Prog 21:532–537
30. Li Z, Zhu S, Gan K et al (2005) Poly-L-lysine-modified silica nanoparticles: a potential oral
gene delivery system. J Nanosci Nanotechnol 5:1199–1203
31. Radu DR, Lai CY, Jeftinija K et al (2004) A polyamidoamine dendrimer-capped mesoporous
silica nanosphere-based gene transfection reagent. J Am Chem Soc 126:13216–13217
32. Kim W, Ng JK, Kunitake ME et al (2007) Interfacing silicon nanowires with mammalian
cells. J Am Chem Soc 129:7228–7229
33. Roy I, Ohulchanskyy TY, Bharali DJ, Pudavar HE, Mistretta RA, Kaur N, Prasa PN (2005)
Optical tracking of organically modified silica nanoparticles as DNA carriers: a nonviral,
nanomedicine approach for gene delivery. Proc Natl Acad Sci USA 102:279–284
34. Chang JS, Chang KL, Hwang DF et al (2007) In vitro cytotoxicitiy of silica nanoparticles at
high concentrations strongly depends on the metabolic activity type of the cell line. Environ
Sci Technol 41:2064–2068
35. Lin W, Huang YW, Zhou XD et al (2006) In vitro toxicity of silica nanoparticles in human
lung cancer cells. Toxicol Appl Pharmacol 217:252–259
36. Cai D, Mataraza JM, Qin ZH et al (2005) Highly efficient molecular delivery into mammalian
cells using carbon nanotube spearing. Nat Methods 2:449–454
Nanoparticles for Gene Delivery into Stem Cells and Embryos
79