58. Oishi M, Hayama T, Akiyama Y et al (2005) Supramolecular assemblies for the cytoplasmic
delivery of antisense oligodeoxynucleotide: polyion complex (PIC) micelles based on poly
(ethylene glycol)-SS-oligodeoxynucleotide conjugate. Biomacromolecules 6:2449–2454
59. Kim SH, Jeong JH, Lee SH et al (2006) PEG conjugated VEGF siRNA for anti-angiogenic
gene therapy. J Control Release 116:123–129
60. Mok H, Park JW, Park TG (2007) Antisense oligodeoxynucleotide-conjugated hyaluronic
acid/protamine nanocomplexes for intracellular gene inhibition. Bioconjug Chem
18:1483–1489
61. Lin C, Zhong Z, Lok MC et al (2007) Novel bioreducible poly(amido amine)s for highly
efficient gene delivery. Bioconjug Chem 18:138–145
62. Namgung R, Brumbach JH, Jeong JH et al (2010) Dual bio-responsive gene delivery via
reducible poly(amido amine) and survivin-inducible plasmid DNA. Biotechnol Lett
32:755–764
63. Lin C, Zhong Z, Lok MC et al (2007) Random and block copolymers of bioreducible poly
(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and
buffer capacity on gene transfection. J Control Release 123:67–75
64. McKenzie DL, Kwok KY, Rice KG (2000) A potent new class of reductively activated
peptide gene delivery agents. J Biol Chem 275:9970–9977
65. McKenzie DL, Smiley E, Kwok KY et al (2000) Low molecular weight disulfide crosslinking peptides as nonviral gene delivery carriers. Bioconjug Chem 11:901–909
66. Oupicky D, Parker AL, Seymour LW (2002) Laterally stabilized complexes of DNA with
linear reducible polycations: strategy for triggered intracellular activation of DNA delivery
vectors. J Am Chem Soc 124:8–9
67. Read ML, Singh S, Ahmed Z et al (2005) A versatile reducible polycation-based system for
efficient delivery of a broad range of nucleic acids. Nucleic Acids Res 33:e86
68. Manickam DS, Oupicky D (2006) Multiblock reducible copolypeptides containing histidinerich and nuclear localization sequences for gene delivery. Bioconjug Chem 17:1395–1403
69. Lo SL, Wang S (2008) An endosomolytic Tat peptide produced by incorporation of histidine
and cysteine residues as a nonviral vector for DNA transfection. Biomaterials 29:2408–2414
70. Won YW, Kim HA, Lee M et al (2010) Reducible poly(oligo-D-arginine) for enhanced gene
expression in mouse lung by intratracheal injection. Mol Ther 18:734–742
71. Green JJ, Zhou BY, Mitalipova MM et al (2008) Nanoparticles for gene transfer to human
embryonic stem cell colonies. Nano Lett 8:3126–3130
72. Kim JH, Park JS, Yang HN et al (2011) The use of biodegradable PLGA nanoparticles to
mediate SOX9 gene delivery in human mesenchymal stem cells (hMSCs) and induce
chondrogenesis. Biomaterials 32:268–278
73. Andersen MO, Lichawska A, Arpanaei A et al (2010) Surface functionalisation of PLGA
nanoparticles for gene silencing. Biomaterials 31:5671–5677
74. Ziady AG, Gedeon CR, Miller T et al (2003) Transfection of airway epithelium by stable
PEGylated poly-L-lysine DNA nanoparticles in vivo. Mol Ther 8:936–947
75. Mao HQ, Roy K, Troung-Le VL et al (2001) Chitosan-DNA nanoparticles as gene carriers:
synthesis, characterization and transfection efficiency. J Control Release 70:399–421
76. Kiang T, Bright C, Cheung CY et al (2004) Formulation of chitosan-DNA nanoparticles with
poly(propyl acrylic acid) enhances gene expression. J Biomater Sci Polym Ed 15:1405–1421
77. Corsi K, Chellat F, Yahia L et al (2003) Mesenchymal stem cells, MG63 and HEK293
transfection using chitosan-DNA nanoparticles. Biomaterials 24:1255–1264
78. Sato N, Kobayashi H, Saga T et al (2001) Tumor targeting and imaging of intraperitoneal
tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice.
Clin Cancer Res 7:3606–3612
79. Gao S, Chen J, Xu X et al (2003) Galactosylated low molecular weight chitosan as DNA
carrier for hepatocyte-targeting. Int J Pharm 255:57–68
80. Kim TH, Park IK, Nah JW et al (2004) Galactosylated chitosan/DNA nanoparticles prepared
using water-soluble chitosan as a gene carrier. Biomaterials 25:3783–3792
Nanoparticles for Gene Delivery into Stem Cells and Embryos
81
delivery of antisense oligodeoxynucleotide: polyion complex (PIC) micelles based on poly
(ethylene glycol)-SS-oligodeoxynucleotide conjugate. Biomacromolecules 6:2449–2454
59. Kim SH, Jeong JH, Lee SH et al (2006) PEG conjugated VEGF siRNA for anti-angiogenic
gene therapy. J Control Release 116:123–129
60. Mok H, Park JW, Park TG (2007) Antisense oligodeoxynucleotide-conjugated hyaluronic
acid/protamine nanocomplexes for intracellular gene inhibition. Bioconjug Chem
18:1483–1489
61. Lin C, Zhong Z, Lok MC et al (2007) Novel bioreducible poly(amido amine)s for highly
efficient gene delivery. Bioconjug Chem 18:138–145
62. Namgung R, Brumbach JH, Jeong JH et al (2010) Dual bio-responsive gene delivery via
reducible poly(amido amine) and survivin-inducible plasmid DNA. Biotechnol Lett
32:755–764
63. Lin C, Zhong Z, Lok MC et al (2007) Random and block copolymers of bioreducible poly
(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and
buffer capacity on gene transfection. J Control Release 123:67–75
64. McKenzie DL, Kwok KY, Rice KG (2000) A potent new class of reductively activated
peptide gene delivery agents. J Biol Chem 275:9970–9977
65. McKenzie DL, Smiley E, Kwok KY et al (2000) Low molecular weight disulfide crosslinking peptides as nonviral gene delivery carriers. Bioconjug Chem 11:901–909
66. Oupicky D, Parker AL, Seymour LW (2002) Laterally stabilized complexes of DNA with
linear reducible polycations: strategy for triggered intracellular activation of DNA delivery
vectors. J Am Chem Soc 124:8–9
67. Read ML, Singh S, Ahmed Z et al (2005) A versatile reducible polycation-based system for
efficient delivery of a broad range of nucleic acids. Nucleic Acids Res 33:e86
68. Manickam DS, Oupicky D (2006) Multiblock reducible copolypeptides containing histidinerich and nuclear localization sequences for gene delivery. Bioconjug Chem 17:1395–1403
69. Lo SL, Wang S (2008) An endosomolytic Tat peptide produced by incorporation of histidine
and cysteine residues as a nonviral vector for DNA transfection. Biomaterials 29:2408–2414
70. Won YW, Kim HA, Lee M et al (2010) Reducible poly(oligo-D-arginine) for enhanced gene
expression in mouse lung by intratracheal injection. Mol Ther 18:734–742
71. Green JJ, Zhou BY, Mitalipova MM et al (2008) Nanoparticles for gene transfer to human
embryonic stem cell colonies. Nano Lett 8:3126–3130
72. Kim JH, Park JS, Yang HN et al (2011) The use of biodegradable PLGA nanoparticles to
mediate SOX9 gene delivery in human mesenchymal stem cells (hMSCs) and induce
chondrogenesis. Biomaterials 32:268–278
73. Andersen MO, Lichawska A, Arpanaei A et al (2010) Surface functionalisation of PLGA
nanoparticles for gene silencing. Biomaterials 31:5671–5677
74. Ziady AG, Gedeon CR, Miller T et al (2003) Transfection of airway epithelium by stable
PEGylated poly-L-lysine DNA nanoparticles in vivo. Mol Ther 8:936–947
75. Mao HQ, Roy K, Troung-Le VL et al (2001) Chitosan-DNA nanoparticles as gene carriers:
synthesis, characterization and transfection efficiency. J Control Release 70:399–421
76. Kiang T, Bright C, Cheung CY et al (2004) Formulation of chitosan-DNA nanoparticles with
poly(propyl acrylic acid) enhances gene expression. J Biomater Sci Polym Ed 15:1405–1421
77. Corsi K, Chellat F, Yahia L et al (2003) Mesenchymal stem cells, MG63 and HEK293
transfection using chitosan-DNA nanoparticles. Biomaterials 24:1255–1264
78. Sato N, Kobayashi H, Saga T et al (2001) Tumor targeting and imaging of intraperitoneal
tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice.
Clin Cancer Res 7:3606–3612
79. Gao S, Chen J, Xu X et al (2003) Galactosylated low molecular weight chitosan as DNA
carrier for hepatocyte-targeting. Int J Pharm 255:57–68
80. Kim TH, Park IK, Nah JW et al (2004) Galactosylated chitosan/DNA nanoparticles prepared
using water-soluble chitosan as a gene carrier. Biomaterials 25:3783–3792
Nanoparticles for Gene Delivery into Stem Cells and Embryos
81