efficacy of orally administered doxorubicin-loaded PLGA nanoparticles (Dox-NPs)
has been performed in breast cancer induced in an animal model. Dox-NPs were
prepared with an entrapment efficiency and particle size of 55% and 160 nm,
respectively (Fig. 8) [46]. Fagui and Amiel studied the preparation and
Fig. 7 SEM images of budesonide-loaded PLGA particles of varying sizes produced by tuning the
concentration and conductivity of PLGA solutions: (a) 5 wt% (1,200 nm), (b) 3 wt% (800 nm),
(c) 0.5 wt% (400 nm), (d) 0.2 wt% (289 nm), and (e) 0.5 wt% (with 10 mM KCl, 165 nm) [45]
2.0 µm
2.0 µm
1.5
1.0
0.5
1.5
1.0
0.5
2.0 µm
0.0 nm
10.0 nm
Fig. 8 AFM image of doxorubicin-loaded PLGA nanoparticles [46]
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