electron microscopy (TEM). In: Fre ´chet JMJ, Tomalia DA (eds) Dendrimers and other
dendritic polymers. Wiley, Chichester, pp 255–284
116. Fre ´chet JMJ (1994) Functional polymers and dendrimers: reactivity, molecular architectures,
and interfacial energy. Science 263:1710–1715
117. Soler-Illia GJ de AA, Rozes L, Boggiano MK, Sanchez C, Turrin C-O, Caminade A-M,
Majoral J-P (2000) New mesotextured hybrid materials made from assemblies of dendrimers
and titanium (IV)-oxo-organo clusters. Angew Chem Int Ed 39(23):4250
118. Boas U, Christensen JB, Heegaard PMH (2006) Dendrimers in medicine and biotechnology.
The Royal Society of Chemistry, Cambridge
119. Menjoge AR, Kannan RM, Tomalia DA (2010) Dendrimer-based drug and imaging conjugates:
design considerations for nanomedical applications. Drug Discov Today 15(5/6):171–185
120. Mintzer MA, Grinstaff MW (2011) Biomedical applications of dendrimers: a tutorial. Chem
Soc Rev 40:173–190
121. Tomalia DA (2005) Birth of a new macromolecular architecture: dendrimers as quantized
building blocks for nanoscale synthetic polymer chemistry. Prog Polym Sci 30:294–324
122. Tomalia DA (2005) The dendritic state. Mater Today 2005(March):34–46
123. Esfand R, Tomalia DA (2001) Poly(amidoamine) (PAMAM) dendrimers: from biomimicry
to drug delivery and biomedical applications. Drug Discov Today 6(8):427–436
124. Piotti ME, Rivera F, Bond R, Hawker CJ, Fre `chet JMJ (1999) Synthesis and catalytic activity
of unimolecular dendritic reverse micelles with “internal” functional groups. J Am Chem Soc
121(40):9471–9472
125. Lim J, Kostiainen M, Maly J, da Costa VCP, Annunziata O, Pavan GM, Simanek EE (2013)
Synthesis of large dendrimers with the dimensions of small viruses. J Am Chem Soc
135:4660–4663
126. Bieniarz C (1998) Dendrimers: applications to pharmaceutical and medicinal chemistry. In:
Encyclopedia of pharmaceutical technology, vol 18. Marcel Dekker, New York, pp 55–89
127. Svenson S, Tomalia DA (2005) Dendrimers in biomedical applications–reflections on the
field. Adv Drug Deliv Rev 57:2106–2129
128. Cheng Y (2012) Dendrimer-based drug delivery systems. Wiley, Hoboken
129. Tully DC, Fre ´chet JMJ (2001) Dendrimers at surfaces and interfaces: chemistry and applications. Chem Commun 2001:1229–1239
130. Jiang D-L, Aida T (2001) Dendritic polymers: optical and photochemical properties. In:
Fre ´chet JMJ, Tomalia DA (eds) Dendrimers and other dendritic polymers. Wiley, Chichester,
pp 425–439
131. Adronov A, Fre ´chet JMJ (2000) Light-harvesting dendrimers. Chem Commun
2000:1701–1710
132. Singh P, Moll F III, Lin SH, Ferzli C (1996) Starburst dendrimers: a novel matrix for
multifunctional reagents in immunoassays. Clin Chem 42(9):1567–1569
133. Singh P (2001) Dendrimer-based biological reagents: preparation and applications in diagnostics. In: Fre ´chet JMJ, Tomalia DA (eds) Dendrimers and dendritic polymers. Wiley,
Chichester, pp 463–484
134. Strathern P (2000) Mendeleyev’s dream. The Berkley Publishing Group, New York
135. Bell TE (2007) Understanding risk assessment of nanotechnology. http://toxipedia.org/
download/attachments/5998572/Understanding_nanoRisk_Assessment.pdf
136. Tomalia DA (2008) Periodic patterns, relationships and categories of well-defined nanoscale
building blocks. National Science Foundation Final Workshop Report pp 1–156. http://www.
nsf.gov/crssprgm/nano/GC_Charact08_Tomalia_nsf9_29_08.pdf
137. Tomalia DA (2009) In quest of a systematic framework for unifying and defining
nanoscience. J Nanopart Res 11:1251–1310
138. Tomalia DA (2010) Dendrons/dendrimer: quantized, nano-element like building blocks for
soft-soft and soft-hard nano-compound synthesis. Soft Matter 6:456–474
139. Anderson PW (1972) More is different. Science 177:393–396
386
D.A. Tomalia
dendritic polymers. Wiley, Chichester, pp 255–284
116. Fre ´chet JMJ (1994) Functional polymers and dendrimers: reactivity, molecular architectures,
and interfacial energy. Science 263:1710–1715
117. Soler-Illia GJ de AA, Rozes L, Boggiano MK, Sanchez C, Turrin C-O, Caminade A-M,
Majoral J-P (2000) New mesotextured hybrid materials made from assemblies of dendrimers
and titanium (IV)-oxo-organo clusters. Angew Chem Int Ed 39(23):4250
118. Boas U, Christensen JB, Heegaard PMH (2006) Dendrimers in medicine and biotechnology.
The Royal Society of Chemistry, Cambridge
119. Menjoge AR, Kannan RM, Tomalia DA (2010) Dendrimer-based drug and imaging conjugates:
design considerations for nanomedical applications. Drug Discov Today 15(5/6):171–185
120. Mintzer MA, Grinstaff MW (2011) Biomedical applications of dendrimers: a tutorial. Chem
Soc Rev 40:173–190
121. Tomalia DA (2005) Birth of a new macromolecular architecture: dendrimers as quantized
building blocks for nanoscale synthetic polymer chemistry. Prog Polym Sci 30:294–324
122. Tomalia DA (2005) The dendritic state. Mater Today 2005(March):34–46
123. Esfand R, Tomalia DA (2001) Poly(amidoamine) (PAMAM) dendrimers: from biomimicry
to drug delivery and biomedical applications. Drug Discov Today 6(8):427–436
124. Piotti ME, Rivera F, Bond R, Hawker CJ, Fre `chet JMJ (1999) Synthesis and catalytic activity
of unimolecular dendritic reverse micelles with “internal” functional groups. J Am Chem Soc
121(40):9471–9472
125. Lim J, Kostiainen M, Maly J, da Costa VCP, Annunziata O, Pavan GM, Simanek EE (2013)
Synthesis of large dendrimers with the dimensions of small viruses. J Am Chem Soc
135:4660–4663
126. Bieniarz C (1998) Dendrimers: applications to pharmaceutical and medicinal chemistry. In:
Encyclopedia of pharmaceutical technology, vol 18. Marcel Dekker, New York, pp 55–89
127. Svenson S, Tomalia DA (2005) Dendrimers in biomedical applications–reflections on the
field. Adv Drug Deliv Rev 57:2106–2129
128. Cheng Y (2012) Dendrimer-based drug delivery systems. Wiley, Hoboken
129. Tully DC, Fre ´chet JMJ (2001) Dendrimers at surfaces and interfaces: chemistry and applications. Chem Commun 2001:1229–1239
130. Jiang D-L, Aida T (2001) Dendritic polymers: optical and photochemical properties. In:
Fre ´chet JMJ, Tomalia DA (eds) Dendrimers and other dendritic polymers. Wiley, Chichester,
pp 425–439
131. Adronov A, Fre ´chet JMJ (2000) Light-harvesting dendrimers. Chem Commun
2000:1701–1710
132. Singh P, Moll F III, Lin SH, Ferzli C (1996) Starburst dendrimers: a novel matrix for
multifunctional reagents in immunoassays. Clin Chem 42(9):1567–1569
133. Singh P (2001) Dendrimer-based biological reagents: preparation and applications in diagnostics. In: Fre ´chet JMJ, Tomalia DA (eds) Dendrimers and dendritic polymers. Wiley,
Chichester, pp 463–484
134. Strathern P (2000) Mendeleyev’s dream. The Berkley Publishing Group, New York
135. Bell TE (2007) Understanding risk assessment of nanotechnology. http://toxipedia.org/
download/attachments/5998572/Understanding_nanoRisk_Assessment.pdf
136. Tomalia DA (2008) Periodic patterns, relationships and categories of well-defined nanoscale
building blocks. National Science Foundation Final Workshop Report pp 1–156. http://www.
nsf.gov/crssprgm/nano/GC_Charact08_Tomalia_nsf9_29_08.pdf
137. Tomalia DA (2009) In quest of a systematic framework for unifying and defining
nanoscience. J Nanopart Res 11:1251–1310
138. Tomalia DA (2010) Dendrons/dendrimer: quantized, nano-element like building blocks for
soft-soft and soft-hard nano-compound synthesis. Soft Matter 6:456–474
139. Anderson PW (1972) More is different. Science 177:393–396
386
D.A. Tomalia