95. Kolb HC, Finn MG, Sharpless KB (2001) Click chemistry: diverse chemical function from a
few good reactions. Angew Chem Int Ed 40:2004–2021
96. Kolb HC, Sharpless KB (2003) The growing impact of click chemistry on drug discovery.
DDT 8(24):1128–1137
97. Buhleier E, Wehner W, Vo ¨gtle F (1978) Cascade – and nonskid-chain-like syntheses of
molecular cavity topologies. Synthesis 405:155–158
98. Huisgen R (1968) Cycloadditions - definition, classification, and characterization. Angew
Chem Int Ed 7(5):321–328
99. Wu P, Feldman AK, Nugent AK, Hawker CJ, Scheel A, Voit B, Pyun J, Frechet JM,
Sharpless KB, Fokin VV (2004) Efficiency and fidelity in a click-chemistry route to triazole
dendrimers by the copper(I)-catalyzed ligation of azides and alkynes. Angew Chem Int Ed
43:3928–3932
100. Joralemon MJ, O’’eilly RK, Matson JB, Nugent AK, Hawker CJ, Wooley KL (2005)
Dendrimers clicked together divergently. Macromolecules 38:5436–5443
101. Wu P, Malkoch M, Hunt JN, Vestberg R, Kaltgrad E, Finn MG, Fokin VV, Sharpless KB,
Hawker CJ (2005) Multivalent, bifunctional dendrimers prepared by click chemistry. Chem
Commun 2005:5775–5777
102. Helms B, Mynar JL, Hawker CJ, Frechet JM (2004) Dendronized linear polymers via “Click
chemistry”. J Am Chem Soc 126:15020–15021
103. Joralemon MJ, O’’eilly RK, Hawker CJ, Wooley KL (2005) Shell click-crosslinked (SCC)
nanoparticles: a new methodology for synthesis and orthogonal functionalization. J Am
Chem Soc 127:16892–16899
104. Sharma A, Desai A, Ali AR, Tomalia DA (2005) Polyacrylamide gel electrophoresis separation and detection of polyamidoamine dendrimers possessing various cores and temrinal
groups. J Chromatogr A 1081:238–244
105. Turro NJ, Barton JK, Tomalia DA (1991) Molecular recognition and chemistry in restricted
reaction spaces. Acc Chem Res 24(11):332–340
106. Gopidas KR, Leheny AR, Caminati G, Turro NJ, Tomalia DA (1991) Photophysical investigation of similarities between starburst dendrimer and anionic micelles. J Am Chem Soc
113:7335–7342
107. Ottaviani MF, Turro NJ, Jockusch S, Tomalia DA (1996) Characterization of starburst
dendrimers by EPR. 3. Aggregational processes of a postively charged nitroxide surfactant.
J Phys Chem 100:13675–13686
108. Jockusch J, Ramirez J, Sanghvi K, Nociti R, Turro NJ, Tomalia DA (1999) Comparison of
nitrogen core and ethylenediamine core starburst dendrimers through photochemical and
spectroscopic probes. Macromolecules 32:4419–4423
109. Hawker CJ, Wooley KL, Fre `chet JMJ (1993) Solvatochromism as a probe of the microenvironment in dendritic polyethers: transition from an extended to a globular structure. J Am
Chem Soc 115(10):4375–4376
110. Yin R, Zhu Y, Tomalia DA (1998) Architectural copolymers: rod-shaped, cylindrical
dendrimers. J Am Chem Soc 120:2678–2679
111. Zhang B, Yu H, Schluter AD, Halperin A, Kroger M (2013) Synthetic regimes due to packing
constraints in dendritic molecules confirmed by labelling experiments. Nat Commun.
doi:10.1038/ncomms2993
112. de Gennes PG, Hervet HJ (1983) Statistics of starburst polymers. J Phys Lett (Paris)
44:351–360
113. Mourey TH, Turner SR, Rubinstein M, Frechet JMJ, Hawer CJ, Wooley KL (1992) Unique
behavior of dendritic macromolecules: intrinsic viscosity of polyether dendrimers. Macromolecules 25(9):2401–2406
114. Maiti PK, Cagin T, Wang G, Goddard WA III (2004) Structure of PAMAM dendrimers:
generation 1 through 11. Macromolecules 37:6236–6254
115. Bauer BJ, Amis EJ (2001) Characterization of dendritically branched polymers by small
angle neutron scattering (SANS), small angle X-ray scattering (SAXS), and transmission
Twenty-First Century Polymer Science After Staudinger: The Emergence of. . .
385
few good reactions. Angew Chem Int Ed 40:2004–2021
96. Kolb HC, Sharpless KB (2003) The growing impact of click chemistry on drug discovery.
DDT 8(24):1128–1137
97. Buhleier E, Wehner W, Vo ¨gtle F (1978) Cascade – and nonskid-chain-like syntheses of
molecular cavity topologies. Synthesis 405:155–158
98. Huisgen R (1968) Cycloadditions - definition, classification, and characterization. Angew
Chem Int Ed 7(5):321–328
99. Wu P, Feldman AK, Nugent AK, Hawker CJ, Scheel A, Voit B, Pyun J, Frechet JM,
Sharpless KB, Fokin VV (2004) Efficiency and fidelity in a click-chemistry route to triazole
dendrimers by the copper(I)-catalyzed ligation of azides and alkynes. Angew Chem Int Ed
43:3928–3932
100. Joralemon MJ, O’’eilly RK, Matson JB, Nugent AK, Hawker CJ, Wooley KL (2005)
Dendrimers clicked together divergently. Macromolecules 38:5436–5443
101. Wu P, Malkoch M, Hunt JN, Vestberg R, Kaltgrad E, Finn MG, Fokin VV, Sharpless KB,
Hawker CJ (2005) Multivalent, bifunctional dendrimers prepared by click chemistry. Chem
Commun 2005:5775–5777
102. Helms B, Mynar JL, Hawker CJ, Frechet JM (2004) Dendronized linear polymers via “Click
chemistry”. J Am Chem Soc 126:15020–15021
103. Joralemon MJ, O’’eilly RK, Hawker CJ, Wooley KL (2005) Shell click-crosslinked (SCC)
nanoparticles: a new methodology for synthesis and orthogonal functionalization. J Am
Chem Soc 127:16892–16899
104. Sharma A, Desai A, Ali AR, Tomalia DA (2005) Polyacrylamide gel electrophoresis separation and detection of polyamidoamine dendrimers possessing various cores and temrinal
groups. J Chromatogr A 1081:238–244
105. Turro NJ, Barton JK, Tomalia DA (1991) Molecular recognition and chemistry in restricted
reaction spaces. Acc Chem Res 24(11):332–340
106. Gopidas KR, Leheny AR, Caminati G, Turro NJ, Tomalia DA (1991) Photophysical investigation of similarities between starburst dendrimer and anionic micelles. J Am Chem Soc
113:7335–7342
107. Ottaviani MF, Turro NJ, Jockusch S, Tomalia DA (1996) Characterization of starburst
dendrimers by EPR. 3. Aggregational processes of a postively charged nitroxide surfactant.
J Phys Chem 100:13675–13686
108. Jockusch J, Ramirez J, Sanghvi K, Nociti R, Turro NJ, Tomalia DA (1999) Comparison of
nitrogen core and ethylenediamine core starburst dendrimers through photochemical and
spectroscopic probes. Macromolecules 32:4419–4423
109. Hawker CJ, Wooley KL, Fre `chet JMJ (1993) Solvatochromism as a probe of the microenvironment in dendritic polyethers: transition from an extended to a globular structure. J Am
Chem Soc 115(10):4375–4376
110. Yin R, Zhu Y, Tomalia DA (1998) Architectural copolymers: rod-shaped, cylindrical
dendrimers. J Am Chem Soc 120:2678–2679
111. Zhang B, Yu H, Schluter AD, Halperin A, Kroger M (2013) Synthetic regimes due to packing
constraints in dendritic molecules confirmed by labelling experiments. Nat Commun.
doi:10.1038/ncomms2993
112. de Gennes PG, Hervet HJ (1983) Statistics of starburst polymers. J Phys Lett (Paris)
44:351–360
113. Mourey TH, Turner SR, Rubinstein M, Frechet JMJ, Hawer CJ, Wooley KL (1992) Unique
behavior of dendritic macromolecules: intrinsic viscosity of polyether dendrimers. Macromolecules 25(9):2401–2406
114. Maiti PK, Cagin T, Wang G, Goddard WA III (2004) Structure of PAMAM dendrimers:
generation 1 through 11. Macromolecules 37:6236–6254
115. Bauer BJ, Amis EJ (2001) Characterization of dendritically branched polymers by small
angle neutron scattering (SANS), small angle X-ray scattering (SAXS), and transmission
Twenty-First Century Polymer Science After Staudinger: The Emergence of. . .
385