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Lutz J-F, Rudolph C (2010) Characterization of tailor-made copolymers of oligo(ethylene
glycol) methyl ether methacrylate and N, N-dimethylaminoethyl methacrylate as nonviral
gene transfer agents: influence of macromolecular structure on gene vector particle properties
and transfection efficiency. Biomacromolecules 11:39–50
194. Verbaan FJ, Oussoren C, Snel CJ, Crommelin DJA, Hennink WE, Storm G (2004) Steric
stabilization of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes mediates
prolonged circulation and tumor targeting in mice. J Gene Med 6:64–75
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X-Z (2011) Influence of block sequences in polymer vectors for gene transfection in vitro and
toxicity assessment of zebrafish embryos in vivo. J Mater Chem 21:4538–4545
196. Xu F-J, Li H, Li J, Zhang Z, Kang E-T, Neoh K-G (2008) Pentablock copolymers of poly
(ethylene glycol), poly((2-dimethyl amino) ethyl methacrylate) and poly(2-hydroxyethyl
methacrylate) from consecutive atom transfer radical polymerizations for non-viral gene
delivery. Biomaterials 29:3023–3033
197. Brissault B, Kichler A, Leborgne C, Danos O, Cheradame H, Gau J, Auvray L, Guis C (2006)
Synthesis, characterization, and gene transfer application of poly(ethylene glycol-bethylenimine) with high molar mass polyamine block. Biomacromolecules 7:2863–2870
198. Liu X-Q, Du J-Z, Zhang C-P, Zhao F, Yang X-Z, Wang J (2010) Brush-shaped polycation
with poly(ethylenimine)-b-poly(ethylene glycol) side chains as highly efficient gene delivery
vector. Int J Pharm 392:118–126
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A. Bertin
Drug Deliv Rev 16:195–214
184. Kleideiter G, Nordmeier E (1999) Poly(ethylene glycol)-induced DNA condensation in
aqueous/methanol containing low-molecular-weight electrolyte solutions. Part II. Comparison between experiment and theory. Polymer 40:4025–4033
185. Toncheva V, Wolfert MA, Dash PR, Oupicky D, Ulbrich K, Seymour LW, Schacht EH
(1998) Novel vectors for gene delivery formed by self-assembly of DNA with poly(L-lysine)
grafted with hydrophilic polymers. Biochim Biophys Acta 1380:354–368
186. Deshpande MC, Davies MC, Garnett MC, Williams PM, Armitage D, Bailey L, Vamvakaki
M, Armes SP, Stolnik S (2004) The effect of poly(ethylene glycol) molecular architecture on
cellular interaction and uptake of DNA complexes. J Control Release 97:143–156
187. Ziebarth J, Wang Y (2010) Coarse-grained molecular dynamics simulations of DNA condensation by block copolymer and formation of core-corona structures. J Phys Chem B
114:6225–6232
188. Petersen H, Fechner PM, Martin AL, Kunath K, Stolnik S, Roberts CJ, Fischer D, Davies MC,
Kissel T (2002) Polyethylenimine-graft-poly(ethylene glycol) copolymers: influence of
copolymer block structure on DNA complexation and biological activities as gene delivery
system. Bioconjug Chem 13:845–854
189. Wakebayashi D, Nishiyama N, Itaka K, Miyata K, Yamasaki Y, Harada A, Koyama H,
Nagasaki Y, Kataoka K, Harada A (2004) Polyion complex micelles of pDNA with acetalpoly(ethylene glycol)-poly(2-(dimethylamino)ethyl methacrylate) block copolymer as the
gene carrier system: physicochemical properties of micelles relevant to gene transfection
efficacy. Biomacromolecules 5:2128–2136
190. Itaka K, Yamauchi K, Harada A, Nakamura K, Kawaguchi H, Kataoka K (2003) Polyion
complex micelles from plasmid DNA and poly(ethylene glycol)-poly(l-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to
gene transfection efficiency. Biomaterials 24:4495–4506
191. Tan JF, Too HP, Hatton TA, Tam KC (2006) Aggregation behavior and thermodynamics of
binding between poly(ethylene oxide)-block-poly(2-(diethylamino)ethyl methacrylate) and
plasmid DNA. Langmuir 22:3744–3750
192. Wang C, Tam KC (2002) New insights on the interaction mechanism within oppositely
charged polymer/surfactant systems. Langmuir 18:6484–6490
193. Uzgun S, Akdemir O, Hasenpusch G, Maucksch C, Golas MM, Sander B, Stark H, Imker R,
Lutz J-F, Rudolph C (2010) Characterization of tailor-made copolymers of oligo(ethylene
glycol) methyl ether methacrylate and N, N-dimethylaminoethyl methacrylate as nonviral
gene transfer agents: influence of macromolecular structure on gene vector particle properties
and transfection efficiency. Biomacromolecules 11:39–50
194. Verbaan FJ, Oussoren C, Snel CJ, Crommelin DJA, Hennink WE, Storm G (2004) Steric
stabilization of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes mediates
prolonged circulation and tumor targeting in mice. J Gene Med 6:64–75
195. Yao Y, Feng D-F, Wu Y-P, Ye Q-J, Liu L, Li X-X, Hou S, Yang Y-L, Wang C, Li L, Feng
X-Z (2011) Influence of block sequences in polymer vectors for gene transfection in vitro and
toxicity assessment of zebrafish embryos in vivo. J Mater Chem 21:4538–4545
196. Xu F-J, Li H, Li J, Zhang Z, Kang E-T, Neoh K-G (2008) Pentablock copolymers of poly
(ethylene glycol), poly((2-dimethyl amino) ethyl methacrylate) and poly(2-hydroxyethyl
methacrylate) from consecutive atom transfer radical polymerizations for non-viral gene
delivery. Biomaterials 29:3023–3033
197. Brissault B, Kichler A, Leborgne C, Danos O, Cheradame H, Gau J, Auvray L, Guis C (2006)
Synthesis, characterization, and gene transfer application of poly(ethylene glycol-bethylenimine) with high molar mass polyamine block. Biomacromolecules 7:2863–2870
198. Liu X-Q, Du J-Z, Zhang C-P, Zhao F, Yang X-Z, Wang J (2010) Brush-shaped polycation
with poly(ethylenimine)-b-poly(ethylene glycol) side chains as highly efficient gene delivery
vector. Int J Pharm 392:118–126
192
A. Bertin