143. van de Wetering P, Moret EE, Schuurmans-Nieuwenbroek NME, van Steenbergen MJ,
Hennink WE (1999) Structure-activity relationships of water-soluble cationic methacrylate/
methacrylamide polymers for nonviral gene delivery. Bioconjug Chem 10:589–597
144. Asayama S, Maruyama A, Cho C-S, Akaike T (1997) Design of comb-type polyamine
copolymers for a novel pH-sensitive DNA carrier. Bioconjug Chem 8:833–838
145. Jiang X, Lok MC, Hennink WE (2007) Degradable-brushed pHEMA-pDMAEMA
synthesized via ATRP and click chemistry for gene delivery. Bioconjug Chem 18:2077–2084
146. Dubruel P, Strycker JD, Westbroek P, Bracke K, Temmerman E, Vandervoort J, Ludwig A,
Schacht E (2002) Synthetic polyamines as vectors for gene delivery. Polym Int 51:948–957
147. Hinrichs WLJ, Schuurmans-Nieuwenbroek NME, van de Wetering P, Hennink WE (1999)
Thermosensitive polymers as carriers for DNA delivery. J Control Release 60:249–259
148. Oupicky D, Reschel T, Konak C, Oupicka L (2003) Temperature-controlled behavior of selfassembly gene delivery vectors based on complexes of DNA with poly(L-lysine)-graft-poly
(N-isopropylacrylamide). Macromolecules 36:6863–6872
149. Cheng N, Liu W, Cao Z, Ji W, Liang D, Guo G, Zhang J (2006) A study of thermoresponsive
poly(N-isopropylacrylamide)/polyarginine bioconjugate non-viral transgene vectors.
Biomaterials 27:4984–4992
150. Putnam D, Gentry CA, Pack DW, Langer R (2001) Polymer-based gene delivery with low
cytotoxicity by a unique balance of side-chain termini. Proc Natl Acad Sci USA
98:1200–1205
151. Chen DJ, Majors BS, Zelikin A, Putnam D (2005) Structure-function relationships of gene
delivery vectors in a limited polycation library. J Control Release 103:273–283
152. Burckhardt G, Zimmer C, Luck G (1976) Conformation and reactivity of DNA in the
complex with protein: IV. Circular dichroism of poly-l-histidine model complexes with
DNA polymers and specificity of the interaction. Nucleic Acids Res 3:561–580
153. Benns JM, Choi J-S, Mahato RI, Park J-S, Kim SW (2000) pH-sensitive cationic polymer
gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer.
Bioconjug Chem 11:637–645
154. Roufai MB, Midoux P (2001) Histidylated polylysine as DNA vector: elevation of the
imidazole protonation and reduced cellular uptake without change in the polyfection efficiency of serum stabilized negative polyplexes. Bioconjug Chem 12:92–99
155. Kim TH, Ihm JE, Choi YJ, Nah JW, Cho CS (2003) Efficient gene delivery by urocanic acidmodified chitosan. J Control Release 93:389–402
156. Park JS, Han TH, Lee KY, Han SS, Hwang JJ, Moon D, Kim SY, Cho YW (2006) N-acetyl
histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release. J Control Release 115:37–45
157. Mishra S, Heidel JD, Webster P, Davis ME (2006) Imidazole groups on a linear,
cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes.
J Control Release 116:179–191
158. Swami A, Aggarwal A, Pathak A, Patnaik S, Kumar P, Singh Y, Gupta KC (2007)
Imidazolyl-PEI modified nanoparticles for enhanced gene delivery. Int J Pharm 335:180–192
159. Pichon C, Goncalves C, Midoux P (2001) Histidine-rich peptides and polymers for nucleic
acids delivery. Adv Drug Deliv Rev 53:75–94
160. Midoux P, Pichon C, Yaouanc J-J, Jaffre `s P-A (2009) Chemical vectors for gene delivery: a
current review on polymers, peptides and lipids containing histidine or imidazole as nucleic
acids carriers. Br J Pharmacol 157:166–178
161. Dekie L, Toncheva V, Dubruel P, Schacht EH, Barrett L, Seymour LW (2000) Poly-Lglutamic acid derivatives as vectors for gene therapy. J Control Release 65:187–202
162. Dubruel P, Dekie L, Schacht E (2003) Poly-L-glutamic acid derivatives as multifunctional
vectors for gene delivery. Part A. Synthesis and physicochemical evaluation. Biomacromolecules 4:1168–1176
190
A. Bertin
Hennink WE (1999) Structure-activity relationships of water-soluble cationic methacrylate/
methacrylamide polymers for nonviral gene delivery. Bioconjug Chem 10:589–597
144. Asayama S, Maruyama A, Cho C-S, Akaike T (1997) Design of comb-type polyamine
copolymers for a novel pH-sensitive DNA carrier. Bioconjug Chem 8:833–838
145. Jiang X, Lok MC, Hennink WE (2007) Degradable-brushed pHEMA-pDMAEMA
synthesized via ATRP and click chemistry for gene delivery. Bioconjug Chem 18:2077–2084
146. Dubruel P, Strycker JD, Westbroek P, Bracke K, Temmerman E, Vandervoort J, Ludwig A,
Schacht E (2002) Synthetic polyamines as vectors for gene delivery. Polym Int 51:948–957
147. Hinrichs WLJ, Schuurmans-Nieuwenbroek NME, van de Wetering P, Hennink WE (1999)
Thermosensitive polymers as carriers for DNA delivery. J Control Release 60:249–259
148. Oupicky D, Reschel T, Konak C, Oupicka L (2003) Temperature-controlled behavior of selfassembly gene delivery vectors based on complexes of DNA with poly(L-lysine)-graft-poly
(N-isopropylacrylamide). Macromolecules 36:6863–6872
149. Cheng N, Liu W, Cao Z, Ji W, Liang D, Guo G, Zhang J (2006) A study of thermoresponsive
poly(N-isopropylacrylamide)/polyarginine bioconjugate non-viral transgene vectors.
Biomaterials 27:4984–4992
150. Putnam D, Gentry CA, Pack DW, Langer R (2001) Polymer-based gene delivery with low
cytotoxicity by a unique balance of side-chain termini. Proc Natl Acad Sci USA
98:1200–1205
151. Chen DJ, Majors BS, Zelikin A, Putnam D (2005) Structure-function relationships of gene
delivery vectors in a limited polycation library. J Control Release 103:273–283
152. Burckhardt G, Zimmer C, Luck G (1976) Conformation and reactivity of DNA in the
complex with protein: IV. Circular dichroism of poly-l-histidine model complexes with
DNA polymers and specificity of the interaction. Nucleic Acids Res 3:561–580
153. Benns JM, Choi J-S, Mahato RI, Park J-S, Kim SW (2000) pH-sensitive cationic polymer
gene delivery vehicle: N-Ac-poly(L-histidine)-graft-poly(L-lysine) comb shaped polymer.
Bioconjug Chem 11:637–645
154. Roufai MB, Midoux P (2001) Histidylated polylysine as DNA vector: elevation of the
imidazole protonation and reduced cellular uptake without change in the polyfection efficiency of serum stabilized negative polyplexes. Bioconjug Chem 12:92–99
155. Kim TH, Ihm JE, Choi YJ, Nah JW, Cho CS (2003) Efficient gene delivery by urocanic acidmodified chitosan. J Control Release 93:389–402
156. Park JS, Han TH, Lee KY, Han SS, Hwang JJ, Moon D, Kim SY, Cho YW (2006) N-acetyl
histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release. J Control Release 115:37–45
157. Mishra S, Heidel JD, Webster P, Davis ME (2006) Imidazole groups on a linear,
cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes.
J Control Release 116:179–191
158. Swami A, Aggarwal A, Pathak A, Patnaik S, Kumar P, Singh Y, Gupta KC (2007)
Imidazolyl-PEI modified nanoparticles for enhanced gene delivery. Int J Pharm 335:180–192
159. Pichon C, Goncalves C, Midoux P (2001) Histidine-rich peptides and polymers for nucleic
acids delivery. Adv Drug Deliv Rev 53:75–94
160. Midoux P, Pichon C, Yaouanc J-J, Jaffre `s P-A (2009) Chemical vectors for gene delivery: a
current review on polymers, peptides and lipids containing histidine or imidazole as nucleic
acids carriers. Br J Pharmacol 157:166–178
161. Dekie L, Toncheva V, Dubruel P, Schacht EH, Barrett L, Seymour LW (2000) Poly-Lglutamic acid derivatives as vectors for gene therapy. J Control Release 65:187–202
162. Dubruel P, Dekie L, Schacht E (2003) Poly-L-glutamic acid derivatives as multifunctional
vectors for gene delivery. Part A. Synthesis and physicochemical evaluation. Biomacromolecules 4:1168–1176
190
A. Bertin