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129. Nisha CK, Manorama SV, Ganguli M, Maiti S, Kizhakkedathu JN (2004) Complexes of poly
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133. Caputo A, Betti M, Altavilla G, Bonaccorsi A, Boarini C, Marchisio M, Butto ` S, Sparnacci K,
Laus M, Tondelli L, Ensoli B (2002) Micellar-type complexes of tailor-made synthetic block
copolymers containing the HIV-1 tat DNA for vaccine application. Vaccine 20:2303–2317
134. Itaka K, Ishii T, Hasegawa Y, Kataoka K (2010) Biodegradable polyamino acid-based
polycations as safe and effective gene carrier minimizing cumulative toxicity. Biomaterials
31:3707–3714
135. Zhang M, Liu M, Xue Y-N, Huang S-W, Zhuo R-X (2009) Polyaspartamide-based oligoethylenimine brushes with high buffer capacity and low cytotoxicity for highly efficient gene
delivery. Bioconjug Chem 20:440–446
136. Cavallaro G, Scire ` S, Licciardi M, Ogris M, Wagner E, Giammona G (2008)
Polyhydroxyethylaspartamide-spermine copolymers: efficient vectors for gene delivery.
J Control Release 131:54–63
137. Liu M, Chen J, Cheng Y-P, Xue Y-N, Zhuo R-X, Huang S-W (2010) Novel poly
(amidoamine)s with pendant primary amines as highly efficient gene delivery vectors.
Macromol Biosci 10:384–392
138. Kim T-I, Kim SW (2011) Bioreducible polymers for gene delivery. React Funct Polym
71:344–349
139. Lin C, Blaauboer C-J, Timoneda MM, Lok MC, van Steenbergen M, Hennink WE, Zhong Z,
Feijen J, Engbersen JFJ (2008) Bioreducible poly(amido amine)s with oligoamine side
chains: synthesis, characterization, and structural effects on gene delivery. J Control Release
126:166–174
140. Du F-S, Wang Y, Zhang R, Li Z-C (2010) Intelligent nucleic acid delivery systems based on
stimuli-responsive polymers. Soft Matter 6:835–848
141. Verbaan FJ, Crommelin DJA, Hennink WE, Storm G (2005) Poly(2-(dimethylamino)ethyl
methacrylate)-based polymers for the delivery of genes in vitro and in vivo. In: Amiji MM
(ed) Polymeric gene delivery-principles and applications. CRC, Boca Raton
142. van de Wetering P, Cherng J-Y, Talsma H, Crommelin DJA, Hennink WE (1998)
2-(dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents. J Control
Release 53:145–153
Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors
189
delivery agents: elucidation of structure-function relationship through modification of charge
density and polymer length. Bioconjug Chem 13:548–553
127. Izumrudov VA, Wahlund P-O, Gustavsson P-E, Larsson P-O, Galaev IY (2003) Factors
controlling phase separation in water-salt solutions of DNA and polycations. Langmuir
19:4733–4739
128. Andersson T, Aseyev V, Tenhu H (2004) Complexation of DNA with poly(methacryl
oxyethyl trimethylammonium chloride) and its poly(oxyethylene) grafted analogue.
Biomacromolecules 5:1853–1861
129. Nisha CK, Manorama SV, Ganguli M, Maiti S, Kizhakkedathu JN (2004) Complexes of poly
(ethylene glycol)-based cationic random copolymer and calf thymus DNA: a complete
biophysical characterization. Langmuir 20:2386–2396
130. Howard KA, Dash PR, Read ML, Ward K, Tomkins LM, Nazarova O, Ulbrich K, Seymour
LW (2000) Influence of hydrophilicity of cationic polymers on the biophysical properties of
polyelectrolyte complexes formed by self-assembly with DNA. Biochim Biophys Acta
1475:245–255
131. Kimura T, Yamaoka T, Iwase R, Murakami A (2002) Effect of physicochemical properties
of polyplexes composed of chemically modified PL derivatives on transfection efficiency
in vitro. Macromol Biosci 2:437–446
132. Licciardi M, Campisi M, Cavallaro G, Carlisi B, Giammona G (2006) Novel cationic
polyaspartamide with covalently linked carboxypropyl-trimethyl ammonium chloride as a
candidate vector for gene delivery. Eur Polym J 42:823–834
133. Caputo A, Betti M, Altavilla G, Bonaccorsi A, Boarini C, Marchisio M, Butto ` S, Sparnacci K,
Laus M, Tondelli L, Ensoli B (2002) Micellar-type complexes of tailor-made synthetic block
copolymers containing the HIV-1 tat DNA for vaccine application. Vaccine 20:2303–2317
134. Itaka K, Ishii T, Hasegawa Y, Kataoka K (2010) Biodegradable polyamino acid-based
polycations as safe and effective gene carrier minimizing cumulative toxicity. Biomaterials
31:3707–3714
135. Zhang M, Liu M, Xue Y-N, Huang S-W, Zhuo R-X (2009) Polyaspartamide-based oligoethylenimine brushes with high buffer capacity and low cytotoxicity for highly efficient gene
delivery. Bioconjug Chem 20:440–446
136. Cavallaro G, Scire ` S, Licciardi M, Ogris M, Wagner E, Giammona G (2008)
Polyhydroxyethylaspartamide-spermine copolymers: efficient vectors for gene delivery.
J Control Release 131:54–63
137. Liu M, Chen J, Cheng Y-P, Xue Y-N, Zhuo R-X, Huang S-W (2010) Novel poly
(amidoamine)s with pendant primary amines as highly efficient gene delivery vectors.
Macromol Biosci 10:384–392
138. Kim T-I, Kim SW (2011) Bioreducible polymers for gene delivery. React Funct Polym
71:344–349
139. Lin C, Blaauboer C-J, Timoneda MM, Lok MC, van Steenbergen M, Hennink WE, Zhong Z,
Feijen J, Engbersen JFJ (2008) Bioreducible poly(amido amine)s with oligoamine side
chains: synthesis, characterization, and structural effects on gene delivery. J Control Release
126:166–174
140. Du F-S, Wang Y, Zhang R, Li Z-C (2010) Intelligent nucleic acid delivery systems based on
stimuli-responsive polymers. Soft Matter 6:835–848
141. Verbaan FJ, Crommelin DJA, Hennink WE, Storm G (2005) Poly(2-(dimethylamino)ethyl
methacrylate)-based polymers for the delivery of genes in vitro and in vivo. In: Amiji MM
(ed) Polymeric gene delivery-principles and applications. CRC, Boca Raton
142. van de Wetering P, Cherng J-Y, Talsma H, Crommelin DJA, Hennink WE (1998)
2-(dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents. J Control
Release 53:145–153
Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors
189