106. Brumbach JH, Lin C, Yockman J, Kim WJ, Blevins KS, Engbersen JFJ, Feijen J, Kim SW
(2010) Mixtures of poly(triethylenetetramine/cystamine bisacrylamide) and poly(triethylenetetramine/cystamine bisacrylamide)-g-poly(ethylene glycol) for improved gene delivery.
Bioconjug Chem 21:1753–1761
107. Allen MHJ, Green MD, Getaneh HK, Miller KM, Long TE (2011) Tailoring charge density
and hydrogen bonding of imidazolium copolymers for efficient gene delivery. Biomacromolecules 12:2243–2250
108. Prevette LE, Kodger TE, Reineke TM, Lynch ML (2007) Deciphering the role of hydrogen
bonding in enhancing pDNA-polycation interactions. Langmuir 23:9773–9784
109. Georgiou TK, Vamvakaki M, Patrickios CS (2004) Nanoscopic cationic methacrylate star
homopolymers: synthesis by group transfer polymerization, characterization and evaluation
as transfection reagents. Biomacromolecules 5:2221–2229
110. Deshpande MC, Garnett MC, Vamvakaki M, Bailey L, Armes SP, Stolnik S (2002) Influence
of polymer architecture on the structure of complexes formed by PEG-tertiary amine methacrylate copolymers and phosphorothioate oligonucleotide. J Control Release 81:185–199
111. Luten J, van Nostrum CF, Smedt SCD, Hennink WE (2008) Biodegradable polymers as
non-viral carriers for plasmid DNA delivery. J Control Release 126:97–110
112. Laga R, Carlisle R, Tangney M, Ulbrich K, Seymour LW (2012) Polymer coatings for
delivery of nucleic acid therapeutics. J Control Release 161:537–553
113. Chan P, Kurisawa M, Chung JE, Yang Y-Y (2007) Synthesis and characterization of
chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials 28:540–549
114. Blessing T, Kursa M, Holzhauser R, Kircheis R, Wagner E (2001) Different strategies for
formation of PEGylated EGF-conjugated PEI/DNA complexes for targeted gene delivery.
Bioconjug Chem 12:529–537
115. Kursa M, Walker GF, Roessler V, Ogris M, Roedl W, Kircheis R, Wagner E (2003) Novel
shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic
tumor-targeted gene transfer. Bioconjug Chem 14:222–231
116. Nishikawa M, Huang L (2001) Non viral vectors in the new millennium: delivery barriers in
gene transfer. Hum Gene Ther 12:861–870
117. Grigsby CL, Leong KW (2010) Balancing protection and release of DNA: tools to address a
bottleneck of non-viral gene delivery. J R Soc Interface 7:S67–S82
118. Soliman M, Allen S, Davies MC, Alexander C (2010) Responsive polyelectrolyte complexes
for triggered release of nucleic acid therapeutics. Chem Commun 46:5421–5433
119. Spain SG, Yasayan G, Soliman M, Heath F, Saeed AO, Alexander C (2011) Nanoparticles for
nucleic acid delivery. In: Ducheyne P (ed) Comprehensive biomaterials, vol 4. Elsevier,
Amsterdam, pp 389–410
120. Sonawane ND, Szoka FC Jr, Verkman A (2003) Chloride accumulation and swelling in
endosomes enhances DNA transfer by polyamine DNA polyplexes. J Biol Chem
278:44826–44831
121. Hunter AC, Moghimi SM (2010) Cationic carriers of genetic material and cell death: a
mitochondrial tale. Biochim Biophys Acta 1797:1203–1209
122. Izumrudov VA, Zhiryakova MV (1999) Stability of DNA-containing interpolyelectrolyte
complexes in water-salt solutions. Macromol Chem Phys 200:2533–2540
123. Xu FJ, Chai MY, Li WB, Ping Y, Tang GP, Yang WT, Ma J, Liu FS (2010) Well-defined poly
(2-hydroxyl-3-(2-hydroxyethylamino)propyl methacrylate) vectors with low toxicity and
high gene transfection efficiency. Biomacromolecules 11:1437–1442
124. Ma M, Li F, Yuan Z-F, Zhuo R-X (2010) Influence of hydroxyl groups on the biological
properties of cationic polymethacrylates as gene vectors. Acta Biomater 6:2658–2665
125. Hemp ST, Allen J, Green MD, Long TE (2012) Phosphonium-containing polyelectrolytes for
nonviral gene delivery. Biomacromolecules 13:231–238
188
A. Bertin
(2010) Mixtures of poly(triethylenetetramine/cystamine bisacrylamide) and poly(triethylenetetramine/cystamine bisacrylamide)-g-poly(ethylene glycol) for improved gene delivery.
Bioconjug Chem 21:1753–1761
107. Allen MHJ, Green MD, Getaneh HK, Miller KM, Long TE (2011) Tailoring charge density
and hydrogen bonding of imidazolium copolymers for efficient gene delivery. Biomacromolecules 12:2243–2250
108. Prevette LE, Kodger TE, Reineke TM, Lynch ML (2007) Deciphering the role of hydrogen
bonding in enhancing pDNA-polycation interactions. Langmuir 23:9773–9784
109. Georgiou TK, Vamvakaki M, Patrickios CS (2004) Nanoscopic cationic methacrylate star
homopolymers: synthesis by group transfer polymerization, characterization and evaluation
as transfection reagents. Biomacromolecules 5:2221–2229
110. Deshpande MC, Garnett MC, Vamvakaki M, Bailey L, Armes SP, Stolnik S (2002) Influence
of polymer architecture on the structure of complexes formed by PEG-tertiary amine methacrylate copolymers and phosphorothioate oligonucleotide. J Control Release 81:185–199
111. Luten J, van Nostrum CF, Smedt SCD, Hennink WE (2008) Biodegradable polymers as
non-viral carriers for plasmid DNA delivery. J Control Release 126:97–110
112. Laga R, Carlisle R, Tangney M, Ulbrich K, Seymour LW (2012) Polymer coatings for
delivery of nucleic acid therapeutics. J Control Release 161:537–553
113. Chan P, Kurisawa M, Chung JE, Yang Y-Y (2007) Synthesis and characterization of
chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. Biomaterials 28:540–549
114. Blessing T, Kursa M, Holzhauser R, Kircheis R, Wagner E (2001) Different strategies for
formation of PEGylated EGF-conjugated PEI/DNA complexes for targeted gene delivery.
Bioconjug Chem 12:529–537
115. Kursa M, Walker GF, Roessler V, Ogris M, Roedl W, Kircheis R, Wagner E (2003) Novel
shielded transferrin-polyethylene glycol-polyethylenimine/DNA complexes for systemic
tumor-targeted gene transfer. Bioconjug Chem 14:222–231
116. Nishikawa M, Huang L (2001) Non viral vectors in the new millennium: delivery barriers in
gene transfer. Hum Gene Ther 12:861–870
117. Grigsby CL, Leong KW (2010) Balancing protection and release of DNA: tools to address a
bottleneck of non-viral gene delivery. J R Soc Interface 7:S67–S82
118. Soliman M, Allen S, Davies MC, Alexander C (2010) Responsive polyelectrolyte complexes
for triggered release of nucleic acid therapeutics. Chem Commun 46:5421–5433
119. Spain SG, Yasayan G, Soliman M, Heath F, Saeed AO, Alexander C (2011) Nanoparticles for
nucleic acid delivery. In: Ducheyne P (ed) Comprehensive biomaterials, vol 4. Elsevier,
Amsterdam, pp 389–410
120. Sonawane ND, Szoka FC Jr, Verkman A (2003) Chloride accumulation and swelling in
endosomes enhances DNA transfer by polyamine DNA polyplexes. J Biol Chem
278:44826–44831
121. Hunter AC, Moghimi SM (2010) Cationic carriers of genetic material and cell death: a
mitochondrial tale. Biochim Biophys Acta 1797:1203–1209
122. Izumrudov VA, Zhiryakova MV (1999) Stability of DNA-containing interpolyelectrolyte
complexes in water-salt solutions. Macromol Chem Phys 200:2533–2540
123. Xu FJ, Chai MY, Li WB, Ping Y, Tang GP, Yang WT, Ma J, Liu FS (2010) Well-defined poly
(2-hydroxyl-3-(2-hydroxyethylamino)propyl methacrylate) vectors with low toxicity and
high gene transfection efficiency. Biomacromolecules 11:1437–1442
124. Ma M, Li F, Yuan Z-F, Zhuo R-X (2010) Influence of hydroxyl groups on the biological
properties of cationic polymethacrylates as gene vectors. Acta Biomater 6:2658–2665
125. Hemp ST, Allen J, Green MD, Long TE (2012) Phosphonium-containing polyelectrolytes for
nonviral gene delivery. Biomacromolecules 13:231–238
188
A. Bertin