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82. Patchornik A, Berger A, Katchalski E (1957) Poly-L-histidine. J Am Chem Soc
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83. Palchaudhuri R, Hergenrother PJ (2007) DNA as a target for anticancer compounds: methods
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84. Hannon MJ (2007) Supramolecular DNA recognition. Chem Soc Rev 36:280–295
85. Mulligan RC (1993) The basic science of gene therapy. Science 260:926–932
86. Verma IM, Somia N (1997) Gene therapy – promises, problems and prospects. Nature
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87. Edelstein ML, Abedi MR, Wixon J, Edelstein RM (2004) Gene therapy clinical trials
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88. Edelstein ML, Abedi MR, Wixon J (2007) Gene therapy clinical trials worldwide to 2007 –
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89. Palmer DH, Young LS, Mautner V (2006) Cancer gene-therapy: clinical trials. Trends
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90. Yeung ML, Bennasser Y, Le SY, Jeang KT (2005) siRNA, miRNA and HIV: promises and
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91. Kay MA, Glorioso JC, Naldini L (2001) Viral vectors for gene therapy: the art of turning
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92. Behr J-P (1993) Synthetic gene-transfer vectors. Acc Chem Res 26:274–278
93. Glover DJ, Lipps HJ, Jans DA (2005) Towards safe, non-viral therapeutic gene expression in
humans. Nat Rev 6:299–310
94. Kawakami S, Higuchi Y, Hashida M (2008) Nonviral approaches for targeted delivery of
plasmid DNA and oligonucleotide. J Pharm Sci 97:726–745
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different tasks for synthetic carriers. J Control Release 161:554–565
96. Zamore PD, Tuschl T, Sharp PA, Bartel DP (2000) RNAi. Cell Res 101:25–33
97. Bonetta L (2004) RNAi: silencing never sounded better. Nat Methods 1:79–86
98. Pecot CV, Calin GA, Coleman RL, Lopez-Berestein G, Sood AK (2011) RNA interference in
the clinic: challenges and future directions. Nat Rev Cancer 11:59–67
99. Wilson RW, Bloomfield VA (1979) Counterion-induced condensation of deoxyribonucleic
acid. A light-scattering study. Biochemistry 18:2192–2196
100. Agarwal S, Zhang Y, Maji S, Greiner A (2012) PDMAEMA based gene delivery materials.
Mater Today 15:388–393
101. Brissault B, Kichler A, Guis C, Leborgne C, Danos O, Cheradame H (2003) Synthesis of
linear polyethylenimine derivatives for DNA transfection. Bioconjug Chem 14:581–587
102. Rungsardthong U, Ehtezazi T, Bailey L, Armes SP, Garnett MC, Stolnik S (2003) Effect of
polymer ionization on the interaction with DNA in nonviral gene delivery systems.
Biomacromolecules 4:683–690
103. Nimesh S, Aggarwal A, Kumar P, Singh Y, Gupta KC, Chandra R (2007) Influence of acyl
chain length on transfection mediated by acylated PEI nanoparticles. Int J Pharm
337:265–274
104. Gabrielson NP, Pack DW (2006) Acetylation of polyethylenimine enhances gene delivery via
weakened polymer/DNA interactions. Biomacromolecules 7:2427–2435
105. Tang GP, Zeng JM, Gao SJ, Ma YX, Shi L, Li Y, Too H-P, Wang S (2003) Polyethylene
glycol modified polyethylenimine for improved CNS gene transfer: effects of PEGylation
extent. Biomaterials 24:2351–2362
Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors
187
In: Comprehensive biomaterials, vol 3: Methods of analysis. Elsevier, Amsterdam, pp
329–339
81. Lebovka NI (2012) Aggregation of charged colloidal particles. In: Mu ¨ller M (ed) Advances in
polymer science. Springer, Berlin, doi: 10.1007/12_2012_171
82. Patchornik A, Berger A, Katchalski E (1957) Poly-L-histidine. J Am Chem Soc
79:5227–5230
83. Palchaudhuri R, Hergenrother PJ (2007) DNA as a target for anticancer compounds: methods
to determine the mode of binding and the mechanism of action. Curr Opin Biotechnol
18:497–503
84. Hannon MJ (2007) Supramolecular DNA recognition. Chem Soc Rev 36:280–295
85. Mulligan RC (1993) The basic science of gene therapy. Science 260:926–932
86. Verma IM, Somia N (1997) Gene therapy – promises, problems and prospects. Nature
389:239–242
87. Edelstein ML, Abedi MR, Wixon J, Edelstein RM (2004) Gene therapy clinical trials
worldwide 1989–2004 – an overview. J Gene Med 6:597–602
88. Edelstein ML, Abedi MR, Wixon J (2007) Gene therapy clinical trials worldwide to 2007 –
an update. J Gene Med 9:833–842
89. Palmer DH, Young LS, Mautner V (2006) Cancer gene-therapy: clinical trials. Trends
Biotechnol 24:76–82
90. Yeung ML, Bennasser Y, Le SY, Jeang KT (2005) siRNA, miRNA and HIV: promises and
challenges. Cell Res 15:935–946
91. Kay MA, Glorioso JC, Naldini L (2001) Viral vectors for gene therapy: the art of turning
infectious agents into vehicles of therapeutics. Nat Med 7:33–40
92. Behr J-P (1993) Synthetic gene-transfer vectors. Acc Chem Res 26:274–278
93. Glover DJ, Lipps HJ, Jans DA (2005) Towards safe, non-viral therapeutic gene expression in
humans. Nat Rev 6:299–310
94. Kawakami S, Higuchi Y, Hashida M (2008) Nonviral approaches for targeted delivery of
plasmid DNA and oligonucleotide. J Pharm Sci 97:726–745
95. Scholz C, Wagner E (2012) Therapeutic plasmid DNA versus siRNA delivery: Common and
different tasks for synthetic carriers. J Control Release 161:554–565
96. Zamore PD, Tuschl T, Sharp PA, Bartel DP (2000) RNAi. Cell Res 101:25–33
97. Bonetta L (2004) RNAi: silencing never sounded better. Nat Methods 1:79–86
98. Pecot CV, Calin GA, Coleman RL, Lopez-Berestein G, Sood AK (2011) RNA interference in
the clinic: challenges and future directions. Nat Rev Cancer 11:59–67
99. Wilson RW, Bloomfield VA (1979) Counterion-induced condensation of deoxyribonucleic
acid. A light-scattering study. Biochemistry 18:2192–2196
100. Agarwal S, Zhang Y, Maji S, Greiner A (2012) PDMAEMA based gene delivery materials.
Mater Today 15:388–393
101. Brissault B, Kichler A, Guis C, Leborgne C, Danos O, Cheradame H (2003) Synthesis of
linear polyethylenimine derivatives for DNA transfection. Bioconjug Chem 14:581–587
102. Rungsardthong U, Ehtezazi T, Bailey L, Armes SP, Garnett MC, Stolnik S (2003) Effect of
polymer ionization on the interaction with DNA in nonviral gene delivery systems.
Biomacromolecules 4:683–690
103. Nimesh S, Aggarwal A, Kumar P, Singh Y, Gupta KC, Chandra R (2007) Influence of acyl
chain length on transfection mediated by acylated PEI nanoparticles. Int J Pharm
337:265–274
104. Gabrielson NP, Pack DW (2006) Acetylation of polyethylenimine enhances gene delivery via
weakened polymer/DNA interactions. Biomacromolecules 7:2427–2435
105. Tang GP, Zeng JM, Gao SJ, Ma YX, Shi L, Li Y, Too H-P, Wang S (2003) Polyethylene
glycol modified polyethylenimine for improved CNS gene transfer: effects of PEGylation
extent. Biomaterials 24:2351–2362
Polyelectrolyte Complexes of DNA and Polycations as Gene Delivery Vectors
187