37. Nagaki A, Kim H, Matsuo C et al (2010) Generation and reaction of cyano-substituted
aryllithium compounds using microreactors. Org Biomol Chem 8:1212–1217
38. Nagaki A, Kim H, Moriwaki Y et al (2010) A flow microreactor system enables
organolithium reactions without protecting alkoxycarbonyl groups. Chem Eur J
16:11167–11177
39. Nagaki A, Takizawa E, Yoshida J (2010) Generation and reactions of oxiranyllithiums by use
of a flow microreactor system. Chem Eur J 16:14149–14158
40. Tomida Y, Nagaki A, Yoshida J (2011) Asymmetric carbolithiation of conjugated enynes:
a flow microreactor enables the use of configurationally unstable intermediates before they
epimerize. J Am Chem Soc 133:3744–3747
41. Kim H, Nagaki A, Yoshida J (2011) A flow-microreactor approach to protecting-group-free
synthesis using organolithium compounds. Nat Commun 2:264
42. Nagaki A, Yamada S, Doi M et al (2011) Flow microreactor synthesis of disubstituted
pyridines from dibromopyridines via Br/Li exchange without using cryogenic conditions.
Green Chem 13:1110–1113
43. Nagaki A, Tokuoka S, Yamada S et al (2011) Perfluoroalkylation in flow microreactors:
generation of perfluoroalkyllithiums in the presence and absence of electrophiles. Org
Biomol Chem 9:7559–7563
44. Asai T, Takata A, Nagaki A et al (2012) Practical synthesis of photochromic diarylethenes in
integrated flow microreactor. ChemSusChem 5:339–350
45. Nagaki A, Matsuo C, Kim S et al (2012) Lithiation of 1,2-dichloroethene in flow
microreactors: versatile synthesis of alkenes and alkynes by precise residence-time control.
Angew Chem Int Ed 51:3245–3248
46. He P, Watts P, Marken F et al (2006) Self-supported and clean one-step cathodic coupling of
. . . Derivatives in a micro flow reactor. Angew Chem Int Ed 45:4146–4149
47. Tanaka K, Motomatsu S, Koyama K et al (2007) Large-scale synthesis of immunoactivating
natural product, pristane, by continuous microfluidic dehydration as the key step. Org Lett
9:299–302
48. Sahoo HR, Kralj JG, Jensen KF (2007) Multi-step continuous flow microchemical synthesis
involving multiple reactions and separations. Angew Chem Int Ed 46:5704–5708
49. Hornung CH, Mackley MR, Baxendale IR et al (2007) A microcapillary flow disc reactor for
organic synthesis. Org Process Res Dev 11:399–405
50. Fukuyama T, Kobayashi M, Rahman MT et al (2008) Spurring radical reactions of organic
halides with tin hydride and TTMSS using microreactors. Org Lett 10:533–536
51. Tricotet T, O’Shea DF (2010) Automated generation and reactions of 3-hydroxymethylindoles
in continuous-flow microreactors. Chem Eur J 16:6678–6686
52. Browne DL, Baumann M, Harji BH et al (2011) A new enabling technology for convenient
laboratory scale continuous flow processing at low temperatures. Org Lett 13:3312–3315
53. Carter CF, Lange H, Sakai D et al (2011) Diastereoselective chain elongation reactions using
microreactors for application in complex molecule assembly. Chem Eur J 17:3398–3405
54. Zaborenko N, Bedore MW, Jamison TF et al (2011) Kinetic and scale-up investigations of
epoxide aminolysis in microreactors at high temperatures and pressures. Org Process Res Dev
15:131–139
55. Noe ´l T, Kuhn S, Musachio AJ et al (2011) Suzuki–Miyaura cross-coupling reactions in flow:
multistep synthesis enabled by a microfluidic extraction. Angew Chem Int Ed 50:5943–5946
56. Gutierrez AC, Jamison TF (2011) Continuous photochemical generation of catalytically
active [CpRu]
+ complexes from CpRu(Z
6
-C 6 H 6 )PF 6 . Org Lett 13:6414–6417
57. Hessel V, Serra C, L€ owe H et al (2005) Polymerisationen in mikrostrukturierten reaktoren:
ein € uberblick. Chem Ing Technol 77:1693–1714
58. Steinbacher JL, Mcquade DT (2006) Polymer chemistry in flow: new polymers, beads,
capsules, and fibers. J Polym Sci A Polym Chem 44:6505–6533
Controlled Polymerization in Flow Microreactor Systems
41
aryllithium compounds using microreactors. Org Biomol Chem 8:1212–1217
38. Nagaki A, Kim H, Moriwaki Y et al (2010) A flow microreactor system enables
organolithium reactions without protecting alkoxycarbonyl groups. Chem Eur J
16:11167–11177
39. Nagaki A, Takizawa E, Yoshida J (2010) Generation and reactions of oxiranyllithiums by use
of a flow microreactor system. Chem Eur J 16:14149–14158
40. Tomida Y, Nagaki A, Yoshida J (2011) Asymmetric carbolithiation of conjugated enynes:
a flow microreactor enables the use of configurationally unstable intermediates before they
epimerize. J Am Chem Soc 133:3744–3747
41. Kim H, Nagaki A, Yoshida J (2011) A flow-microreactor approach to protecting-group-free
synthesis using organolithium compounds. Nat Commun 2:264
42. Nagaki A, Yamada S, Doi M et al (2011) Flow microreactor synthesis of disubstituted
pyridines from dibromopyridines via Br/Li exchange without using cryogenic conditions.
Green Chem 13:1110–1113
43. Nagaki A, Tokuoka S, Yamada S et al (2011) Perfluoroalkylation in flow microreactors:
generation of perfluoroalkyllithiums in the presence and absence of electrophiles. Org
Biomol Chem 9:7559–7563
44. Asai T, Takata A, Nagaki A et al (2012) Practical synthesis of photochromic diarylethenes in
integrated flow microreactor. ChemSusChem 5:339–350
45. Nagaki A, Matsuo C, Kim S et al (2012) Lithiation of 1,2-dichloroethene in flow
microreactors: versatile synthesis of alkenes and alkynes by precise residence-time control.
Angew Chem Int Ed 51:3245–3248
46. He P, Watts P, Marken F et al (2006) Self-supported and clean one-step cathodic coupling of
. . . Derivatives in a micro flow reactor. Angew Chem Int Ed 45:4146–4149
47. Tanaka K, Motomatsu S, Koyama K et al (2007) Large-scale synthesis of immunoactivating
natural product, pristane, by continuous microfluidic dehydration as the key step. Org Lett
9:299–302
48. Sahoo HR, Kralj JG, Jensen KF (2007) Multi-step continuous flow microchemical synthesis
involving multiple reactions and separations. Angew Chem Int Ed 46:5704–5708
49. Hornung CH, Mackley MR, Baxendale IR et al (2007) A microcapillary flow disc reactor for
organic synthesis. Org Process Res Dev 11:399–405
50. Fukuyama T, Kobayashi M, Rahman MT et al (2008) Spurring radical reactions of organic
halides with tin hydride and TTMSS using microreactors. Org Lett 10:533–536
51. Tricotet T, O’Shea DF (2010) Automated generation and reactions of 3-hydroxymethylindoles
in continuous-flow microreactors. Chem Eur J 16:6678–6686
52. Browne DL, Baumann M, Harji BH et al (2011) A new enabling technology for convenient
laboratory scale continuous flow processing at low temperatures. Org Lett 13:3312–3315
53. Carter CF, Lange H, Sakai D et al (2011) Diastereoselective chain elongation reactions using
microreactors for application in complex molecule assembly. Chem Eur J 17:3398–3405
54. Zaborenko N, Bedore MW, Jamison TF et al (2011) Kinetic and scale-up investigations of
epoxide aminolysis in microreactors at high temperatures and pressures. Org Process Res Dev
15:131–139
55. Noe ´l T, Kuhn S, Musachio AJ et al (2011) Suzuki–Miyaura cross-coupling reactions in flow:
multistep synthesis enabled by a microfluidic extraction. Angew Chem Int Ed 50:5943–5946
56. Gutierrez AC, Jamison TF (2011) Continuous photochemical generation of catalytically
active [CpRu]
+ complexes from CpRu(Z
6
-C 6 H 6 )PF 6 . Org Lett 13:6414–6417
57. Hessel V, Serra C, L€ owe H et al (2005) Polymerisationen in mikrostrukturierten reaktoren:
ein € uberblick. Chem Ing Technol 77:1693–1714
58. Steinbacher JL, Mcquade DT (2006) Polymer chemistry in flow: new polymers, beads,
capsules, and fibers. J Polym Sci A Polym Chem 44:6505–6533
Controlled Polymerization in Flow Microreactor Systems
41