12. deMello AJ (2006) Control and detection of chemical reactions in microfluidic systems.
Nature 442:394–402
13. Song H, Chen DL, Ismagilov RF (2006) Reactions in droplets in microfluidic channels.
Angew Chem Int Ed 45:7336–7356
14. Kobayashi J, Mori Y, Kobayashi S (2006) Multiphase organic synthesis in microchannel
reactors. Chem Asian J 1:22–35
15. Brivio M, Verboom W, Reinhoudt DN (2006) Miniaturized continuous flow reaction vessels:
influence on chemical reactions. Lab Chip 6:329–344
16. Mason BP, Price KE, Steinbacher JL et al (2007) Greener approaches to organic synthesis
using microreactor technology. Chem Rev 107:2300–2318
17. Ahmed-Omer B, Brandtand JC, Wirth T (2007) Advanced organic synthesis using
microreactor technology. Org Biomol Chem 5:733–740
18. Watts P, Wiles C (2007) Recent advances in synthetic micro reaction technology. Chem
Commun 443–467
19. Fukuyama T, Rahman MT, Sato M et al (2008) Adventures in inner space: microflow systems
for practical organic synthesis. Synlett 151–163
20. Lin W, Wang Y, Wang S et al (2009) Integrated microfluidic reactors. Nano Today
4:470–481
21. McMullen JP, Jensen KF (2010) Integrated microreactors for reaction automation: new
approaches to reaction development. Annu Rev Anal Chem 3:19–42
22. Ley SV (2010) The changing face of organic synthesis. Tetrahedron 66:6270–6292
23. Webb D, Jamison TF (2010) Continuous flow multi-step organic synthesis. Chem Sci
1:675–680
24. Yoshida J, Kim H, Nagaki A (2011) Green and sustainable chemical synthesis using flow
microreactors. ChemSusChem 4:331–340
25. Chambers RD, Holling D, Spink RCH et al (2001) Elemental fluorine. Part 13. Gas-liquid
thin film microreactors for selective direct fluorination. Lab Chip 1:132–137
26. J€ ahnisch K, Baerns M, Hessel V et al (2000) Direct fluorination of toluene using elemental
fluorine in gas/liquid microreactors. J Fluor Chem 105:117–123
27. Ducry L, Roberge DM (2005) Controlled autocatalytic nitration of phenol in a microreactor.
Angew Chem Int Ed 44:7972–7975
28. Wakami H, Yoshida J (2005) Grignard exchange reaction using a microflow system: from
bench to pilot plan. Org Process Res Dev 9:787–791
29. Usutani H, Tomida Y, Nagaki A et al (2007) Generation and reactions of o-bromophenyllithium without benzyne formation using a microreactor. J Am Chem Soc 129:3046–3047
30. Nagaki A, Tomida Y, Usutani H et al (2007) Integrated micro flow synthesis based on
sequential Br-Li exchange reactions of p-, m-, and o-dibromobenzenes. Chem Asian J
2:1513–1523
31. Nagaki A, Kim H, Yoshida J (2008) Aryllithium compounds bearing alkoxycarbonyl groups.
Generation and reactions using a microflow system. Angew Chem Int Ed 47:7833–7836
32. Nagaki A, Takizawa E, Yoshida J (2009) Oxiranyl anion methodology using microflow
systems. J Am Chem Soc 131:1654–1655
33. Nagaki A, Kim H, Yoshida J (2009) Nitro-substituted aryl lithium compounds in
microreactor synthesis: switch between kinetic and thermodynamic control. Angew Chem
Int Ed 48:8063–8065
34. Tomida Y, Nagaki A, Yoshida J (2009) Carbolithiation of conjugated enynes with
aryllithiums in microflow system and applications to synthesis of allenylsilanes. Org Lett
11:3614–3617
35. Nagaki A, Takizawa E, Yoshida J (2009) Generation and reactions of a-silyloxiranyllithium
in a microreactor. Chem Lett 38:486–487
36. Nagaki A, Takizawa E, Yoshida J (2009) Generations and reactions of N-tert-butylsulfonylaziridinyllithiums using microreactors. Chem Lett 38:1060–1061
40
A. Nagaki and J.-i. Yoshida
Nature 442:394–402
13. Song H, Chen DL, Ismagilov RF (2006) Reactions in droplets in microfluidic channels.
Angew Chem Int Ed 45:7336–7356
14. Kobayashi J, Mori Y, Kobayashi S (2006) Multiphase organic synthesis in microchannel
reactors. Chem Asian J 1:22–35
15. Brivio M, Verboom W, Reinhoudt DN (2006) Miniaturized continuous flow reaction vessels:
influence on chemical reactions. Lab Chip 6:329–344
16. Mason BP, Price KE, Steinbacher JL et al (2007) Greener approaches to organic synthesis
using microreactor technology. Chem Rev 107:2300–2318
17. Ahmed-Omer B, Brandtand JC, Wirth T (2007) Advanced organic synthesis using
microreactor technology. Org Biomol Chem 5:733–740
18. Watts P, Wiles C (2007) Recent advances in synthetic micro reaction technology. Chem
Commun 443–467
19. Fukuyama T, Rahman MT, Sato M et al (2008) Adventures in inner space: microflow systems
for practical organic synthesis. Synlett 151–163
20. Lin W, Wang Y, Wang S et al (2009) Integrated microfluidic reactors. Nano Today
4:470–481
21. McMullen JP, Jensen KF (2010) Integrated microreactors for reaction automation: new
approaches to reaction development. Annu Rev Anal Chem 3:19–42
22. Ley SV (2010) The changing face of organic synthesis. Tetrahedron 66:6270–6292
23. Webb D, Jamison TF (2010) Continuous flow multi-step organic synthesis. Chem Sci
1:675–680
24. Yoshida J, Kim H, Nagaki A (2011) Green and sustainable chemical synthesis using flow
microreactors. ChemSusChem 4:331–340
25. Chambers RD, Holling D, Spink RCH et al (2001) Elemental fluorine. Part 13. Gas-liquid
thin film microreactors for selective direct fluorination. Lab Chip 1:132–137
26. J€ ahnisch K, Baerns M, Hessel V et al (2000) Direct fluorination of toluene using elemental
fluorine in gas/liquid microreactors. J Fluor Chem 105:117–123
27. Ducry L, Roberge DM (2005) Controlled autocatalytic nitration of phenol in a microreactor.
Angew Chem Int Ed 44:7972–7975
28. Wakami H, Yoshida J (2005) Grignard exchange reaction using a microflow system: from
bench to pilot plan. Org Process Res Dev 9:787–791
29. Usutani H, Tomida Y, Nagaki A et al (2007) Generation and reactions of o-bromophenyllithium without benzyne formation using a microreactor. J Am Chem Soc 129:3046–3047
30. Nagaki A, Tomida Y, Usutani H et al (2007) Integrated micro flow synthesis based on
sequential Br-Li exchange reactions of p-, m-, and o-dibromobenzenes. Chem Asian J
2:1513–1523
31. Nagaki A, Kim H, Yoshida J (2008) Aryllithium compounds bearing alkoxycarbonyl groups.
Generation and reactions using a microflow system. Angew Chem Int Ed 47:7833–7836
32. Nagaki A, Takizawa E, Yoshida J (2009) Oxiranyl anion methodology using microflow
systems. J Am Chem Soc 131:1654–1655
33. Nagaki A, Kim H, Yoshida J (2009) Nitro-substituted aryl lithium compounds in
microreactor synthesis: switch between kinetic and thermodynamic control. Angew Chem
Int Ed 48:8063–8065
34. Tomida Y, Nagaki A, Yoshida J (2009) Carbolithiation of conjugated enynes with
aryllithiums in microflow system and applications to synthesis of allenylsilanes. Org Lett
11:3614–3617
35. Nagaki A, Takizawa E, Yoshida J (2009) Generation and reactions of a-silyloxiranyllithium
in a microreactor. Chem Lett 38:486–487
36. Nagaki A, Takizawa E, Yoshida J (2009) Generations and reactions of N-tert-butylsulfonylaziridinyllithiums using microreactors. Chem Lett 38:1060–1061
40
A. Nagaki and J.-i. Yoshida