constituent and underscores the basic dilemma of RCM in applications to
stereochemically defined molecules [30] (cf. Sect. 3.5.1) (Scheme 16).
2.6 16-Membered Macrocyclic Lactones
2.6.1 Epothilone A
The potent biological activity of the epothilones rendered them important targets
for the synthetic community and the very early total syntheses of epothilone A 39
Scheme 8 RCAM-based synthesis of enantiomeric amphidinolide V, 31
Scheme 9 RCAM-based synthesis of epilachnene, 34
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M. Cordes and M. Kalesse
stereochemically defined molecules [30] (cf. Sect. 3.5.1) (Scheme 16).
2.6 16-Membered Macrocyclic Lactones
2.6.1 Epothilone A
The potent biological activity of the epothilones rendered them important targets
for the synthetic community and the very early total syntheses of epothilone A 39
Scheme 8 RCAM-based synthesis of enantiomeric amphidinolide V, 31
Scheme 9 RCAM-based synthesis of epilachnene, 34
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M. Cordes and M. Kalesse