target molecules. This strategy has been applied by Legraverend and Ibrahim in
the preparation of 6,7,8-trisubstituted purines 66 and 67 from aryl iodides 65 [55].
Le Bras et al. recently reported an efficient method for preparing 2-mercapto
benzimidazoles (Scheme 24) [56]. In their process, S-alkylation of thioureas 45
Scheme 21 CuBr-catalyzed synthesis of 1H-benzimidazoles from o-haloacetanilides and amidine
hydrochlorides
Scheme 22 CuI-DMEDA-catalyzed synthesis of 1H-2-substituted benzimidazoles from
1,2-dihaloarenes, amidines and guanidines
Scheme 23 CuI/DMCyDA catalyzed coupling of o-haloanilines with amides
Scheme 24 CuI-catalyzed synthesis of substituted 2-mercapto benzimidazoles
Assembly of N-Containing Heterocycles via Pd- and Cu-Catalyzed C–N Bond. . .
97
the preparation of 6,7,8-trisubstituted purines 66 and 67 from aryl iodides 65 [55].
Le Bras et al. recently reported an efficient method for preparing 2-mercapto
benzimidazoles (Scheme 24) [56]. In their process, S-alkylation of thioureas 45
Scheme 21 CuBr-catalyzed synthesis of 1H-benzimidazoles from o-haloacetanilides and amidine
hydrochlorides
Scheme 22 CuI-DMEDA-catalyzed synthesis of 1H-2-substituted benzimidazoles from
1,2-dihaloarenes, amidines and guanidines
Scheme 23 CuI/DMCyDA catalyzed coupling of o-haloanilines with amides
Scheme 24 CuI-catalyzed synthesis of substituted 2-mercapto benzimidazoles
Assembly of N-Containing Heterocycles via Pd- and Cu-Catalyzed C–N Bond. . .
97