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185
Maeda T, García-Contreras R, Pu M et al. (2012) Quorum quenching quandary: resistance to
antivirulence compounds. ISME J 6:493–501
Mashalidis EH, Kaeser B, Terasawa Y et al. (2019) Chemical logic of MraY inhibition by
antibacterial nucleoside natural products. Nat Commun 10 (1):2917
Megget K (2018) Novartis exit from antibiotics a setback for race against resistance. Chem World
15(9):48–49
Monserrat-Martinez A, Gambin Y, Sierecki E (2019) Thinking outside the bug: Molecular targets
and strategies to overcome antibiotic resistance. Int J Mol Sci 20 (6):1255
Mullard A (2017) The drug-maker’s guide to the galaxy. Nature 549 (7673):445–447
Nickerson NN, Jao CC, Xu Y et al. (2018) A Novel inhibitor of the LolCDE ABC transporter
essential for lipoprotein trafficking in Gram-negative bacteria. Antimicrob Agents Chemother 62
(4):e02151–02117
Nizalapur S, Kimyon Ö, Biswas NN et al. (2016) Design, synthesis and evaluation of N-arylglyoxamide derivatives as structurally novel bacterial quorum sensing inhibitors. Org Biomol
Chem 14 (2):680–693
Nuti DE, Crump RB, Dwi Handayani F et al. (2011) Identification of circulating bacterial antigens
by in vivo microbial antigen discovery. mBio 2 (4):e00136–11
Pant B, Kato Y, Kumagai T et al. (1997) Blepharismin produced by a protozoan Blepharisma
functions as an antibiotic effective against methicillin-resistant Staphylococcus aureus. FEMS
Microbiol Lett 155 (1):67–71
Peeters SH, de Jonge MI (2018) For the greater good: Programmed cell death in bacterial
communities. Microbiol Res 207:161–169
Petrelli D, Buonanno F, Vitali LA et al. (2012). Antimicrobial activity of the protozoan toxin
climacostol and its derivatives. Biologia 67:525–529
Psonis JJ, Thanassi DG (2019) Therapeutic approaches targeting the assembly and function of
chaperone-usher pili. EcoSal Plus 8 (2). https://doi.org/10.1128/ecosalplus.ESP-0033-2018
Rader C (2015) How to minimalize antibodies. Nature 518 (7537):38–39
Rasko DA, Moreira CG, Li de R et al. (2008) Targeting QseC signaling and virulence for antibiotic
development. Science 321 (5892):1078–1080
Renaud J-P, Chari A, Ciferri C et al. (2018) Cryo-EM in drug discovery: achievements, limitations
and prospects. Nat Rev Drug Discov 17 (7):471–492
Ribet D, Cossart P (2018) Ubiquitin, SUMO, and NEDD8: Key targets of bacterial pathogens.
Trends Cell Biol 28 (11):926–940
Rideout MC, Boldt JL, Vahi-Ferguson G et al. (2011) Potent antimicrobial small molecules screened
as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes. Mol Divers 15
(4):989
Robinson A, van Oijen AM (2013) Bacterial replication, transcription and translation: mechanistic
insights from single-molecule biochemical studies. Nat Rev Microbiol 11 (5):303–315
Robinson JA (2019) Folded synthetic peptides and other molecules targeting outer membrane protein
complexes in Gram-negative bacteria. Front Chem 7: Article 45
Rodrigues T, Werner M, Roth J et al. (2018) Machine intelligence decrypts β-lapachone as an
allosteric 5-lipoxygenase inhibitor. Chem Sci 9 (34):6899–6903
Sader HS, Dale GE, Rhomberg PR et al. (2018) Antimicrobial activity of murepavadin tested
against clinical isolates of Pseudomonas aeruginosa from the United States, Europe, and China.
Antimicrob Agents Chemother 62 (7):e00311–00318
Sakakibara D, Sasaki A, Ikeya T et al. (2009) Protein structure determination in living cells by
in-cell NMR spectroscopy. Nature 458 (7234):102–105
Scapin G, Potter CS, Carragher B (2018) Cryo-EM for small molecules discovery, design,
understanding, and application. Cell Chem Biol 25 (11):1318–1325
Schaenzer AJ, Wlodarchak N, Drewry DH et al. (2017) A screen for kinase inhibitors identifies
antimicrobial imidazopyridine aminofurazans as specific inhibitors of the Listeria monocytogenes
PASTA kinase PrkA. J Biol Chem 292 (41):17037–17045