184
5 Future Possibilities
Heras B, Scanlon MJ, Martin JL (2015) Targeting virulence not viability in the search for future
antibacterials. Br J Clin Pharmacol 79 (2):208–215
Herzik MA, Jr. (2020) Cryo-electron microscopy reaches atomic resolution. Nature 587 (7832):39–
40
Ho H, Miu A, Alexander MK et al. (2018) Structural basis for dual-mode inhibition of the ABC
transporter MsbA. Nature 557 (7704):196–201
Hu LI, Lima BP, Wolfe AJ (2010a) Bacterial protein acetylation: the dawning of a new age. Mol
Microbiol 77 (1):15–21
Hu Y, Shamaei-Tousi A, Liu Y et al. (2010b) A new approach for the discovery of antibiotics by
targeting non-multiplying bacteria: A novel topical antibiotic for staphylococcal infections. PLoS
One 5 (7):e11818
Ikeya T, Hanashima T, Hosoya S et al. (2016) Improved in-cell structure determination of proteins
at near-physiological concentration. Sci Rep 6 (1):38312
Imai Y, Meyer KJ, Iinishi A et al. (2019) A new antibiotic selectively kills Gram-negative pathogens.
Nature 576 (7787):459–464
Jia X, Lynch A, Huang Y et al. (2019) Anthropogenic biases in chemical reaction data hinder
exploratory inorganic synthesis. Nature 573 (7773):251–255
Jacobsson S, Mason C, Khan N et al. (2019) In vitro activity of the novel oral antimicrobial SMT571, with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae: future
treatment options for gonorrhoea? J Antimicrob Chemother 74: 1591–1594
Johnson EO, LaVerriere E, Office E et al. (2019) Large-scale chemical-genetics yields new M.
tuberculosis inhibitor classes. Nature 571 (7763):72–78
Keller MD, Ching KL, Liang FX et al. (2020) Decoy exosomes provide protection against bacterial
toxins. Nature 579 (7798):260–264
Koppermann S, Cui Z, Fischer PD et al. (2018) Insights into the target interaction of naturally
occurring muraymycin nucleoside antibiotics. ChemMedChem 13 (8):779–784
Krajewski SS, Ignatov D, Johansson J (2017) Two are better than one: Dual targeting of riboswitches
by metabolite analogs. Cell Chem Biol 24 (5):535–537
Kroeck KG, Sacco MD, Smith EW et al. (2019) Discovery of dual-activity small-molecule ligands
of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography. Sci Rep 9
(1):15450
Kumar V, Turnbull WB (2018) Carbohydrate inhibitors of cholera toxin. Beilstein J Org Chem
14:484–498
Leaver DJ, Dawson RM, White JM et al. (2011) Synthesis of 1,2,3-triazole linked galactopyranosides and evaluation of cholera toxin inhibition. Org Biomol Chem 9 (24):8465–8474
Lebraud H, Wright DJ, Johnson CN et al. (2016) Protein degradation by in-cell self-assembly of
proteolysis targeting chimeras. ACS Cent Sci 2 (12):927–934
Lewis K (2013) Platforms for antibiotic discovery. Nat Rev Drug Discov 12 (5):371–387
Liu F, Ma S (2018) Recent process in the inhibitors of UDP-3-O-(R-3-hydroxyacyl)-Nacetylglucosamine deacetylase (LpxC) against Gram-negative bacteria. Mini Rev Med Chem
18 (4):310–323
Lobban CS, Hallam SJ, Mukherjee P et al. (2007) Photophysics and multifunctionality of hypericinlike pigments in heterotrich ciliates: A phylogenetic perspective. Photochem Photobiol 83:1074–
1094
Lok C (2015) Mining the microbial dark matter. Nature 522 (7556):270–273
Luechtefeld T, Marsh D, Rowlands C et al. (2018) Machine learning of toxicological big data enables
read-across structure activity relationships (RASAR) outperforming animal test reproducibility.
Toxicol Sci 165 (1):198–212
Lupoli TJ, Vaubourgeix J, Burns-Huang K et al. (2018) Targeting the proteostasis network for
mycobacterial drug discovery. ACS Infect Dis 4:478–498
Luther A, Urfer M, Zahn M et al. (2019) Chimeric peptidomimetic antibiotics against Gram-negative
bacteria. Nature 576 (7787):452–458
5 Future Possibilities
Heras B, Scanlon MJ, Martin JL (2015) Targeting virulence not viability in the search for future
antibacterials. Br J Clin Pharmacol 79 (2):208–215
Herzik MA, Jr. (2020) Cryo-electron microscopy reaches atomic resolution. Nature 587 (7832):39–
40
Ho H, Miu A, Alexander MK et al. (2018) Structural basis for dual-mode inhibition of the ABC
transporter MsbA. Nature 557 (7704):196–201
Hu LI, Lima BP, Wolfe AJ (2010a) Bacterial protein acetylation: the dawning of a new age. Mol
Microbiol 77 (1):15–21
Hu Y, Shamaei-Tousi A, Liu Y et al. (2010b) A new approach for the discovery of antibiotics by
targeting non-multiplying bacteria: A novel topical antibiotic for staphylococcal infections. PLoS
One 5 (7):e11818
Ikeya T, Hanashima T, Hosoya S et al. (2016) Improved in-cell structure determination of proteins
at near-physiological concentration. Sci Rep 6 (1):38312
Imai Y, Meyer KJ, Iinishi A et al. (2019) A new antibiotic selectively kills Gram-negative pathogens.
Nature 576 (7787):459–464
Jia X, Lynch A, Huang Y et al. (2019) Anthropogenic biases in chemical reaction data hinder
exploratory inorganic synthesis. Nature 573 (7773):251–255
Jacobsson S, Mason C, Khan N et al. (2019) In vitro activity of the novel oral antimicrobial SMT571, with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae: future
treatment options for gonorrhoea? J Antimicrob Chemother 74: 1591–1594
Johnson EO, LaVerriere E, Office E et al. (2019) Large-scale chemical-genetics yields new M.
tuberculosis inhibitor classes. Nature 571 (7763):72–78
Keller MD, Ching KL, Liang FX et al. (2020) Decoy exosomes provide protection against bacterial
toxins. Nature 579 (7798):260–264
Koppermann S, Cui Z, Fischer PD et al. (2018) Insights into the target interaction of naturally
occurring muraymycin nucleoside antibiotics. ChemMedChem 13 (8):779–784
Krajewski SS, Ignatov D, Johansson J (2017) Two are better than one: Dual targeting of riboswitches
by metabolite analogs. Cell Chem Biol 24 (5):535–537
Kroeck KG, Sacco MD, Smith EW et al. (2019) Discovery of dual-activity small-molecule ligands
of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography. Sci Rep 9
(1):15450
Kumar V, Turnbull WB (2018) Carbohydrate inhibitors of cholera toxin. Beilstein J Org Chem
14:484–498
Leaver DJ, Dawson RM, White JM et al. (2011) Synthesis of 1,2,3-triazole linked galactopyranosides and evaluation of cholera toxin inhibition. Org Biomol Chem 9 (24):8465–8474
Lebraud H, Wright DJ, Johnson CN et al. (2016) Protein degradation by in-cell self-assembly of
proteolysis targeting chimeras. ACS Cent Sci 2 (12):927–934
Lewis K (2013) Platforms for antibiotic discovery. Nat Rev Drug Discov 12 (5):371–387
Liu F, Ma S (2018) Recent process in the inhibitors of UDP-3-O-(R-3-hydroxyacyl)-Nacetylglucosamine deacetylase (LpxC) against Gram-negative bacteria. Mini Rev Med Chem
18 (4):310–323
Lobban CS, Hallam SJ, Mukherjee P et al. (2007) Photophysics and multifunctionality of hypericinlike pigments in heterotrich ciliates: A phylogenetic perspective. Photochem Photobiol 83:1074–
1094
Lok C (2015) Mining the microbial dark matter. Nature 522 (7556):270–273
Luechtefeld T, Marsh D, Rowlands C et al. (2018) Machine learning of toxicological big data enables
read-across structure activity relationships (RASAR) outperforming animal test reproducibility.
Toxicol Sci 165 (1):198–212
Lupoli TJ, Vaubourgeix J, Burns-Huang K et al. (2018) Targeting the proteostasis network for
mycobacterial drug discovery. ACS Infect Dis 4:478–498
Luther A, Urfer M, Zahn M et al. (2019) Chimeric peptidomimetic antibiotics against Gram-negative
bacteria. Nature 576 (7787):452–458