186
5 Future Possibilities
Schilling NA, Berscheid A, Schumacher J et al. (2019) Synthetic lugdunin analogues reveal essential
structural motifs for antimicrobial action and proton translocation capability. Angew Chem Int
Ed 58 (27):9234–9238
Schütz C, Empting M (2018) Targeting the Pseudomonas quinolone signal quorum sensing system
for the discovery of novel anti-infective pathoblockers. Beilstein J Org Chem 14:2627–2645
Segler MHS, Preuss M, Waller MP (2018) Planning chemical syntheses with deep neural networks
and symbolic AI. Nature 555 (7698):604–610
Shang Z, Winter JM, Kauffman CA et al. (2019) Salinipeptins: Integrated genomic and chemical approaches reveal unusual D-amino acid-containing ribosomally synthesized and posttranslationally modified peptides (RiPPs) from a Great Salt Lake Streptomyces sp. ACS Chem
Biol 14:415–425
Shlaes D (2018) What’s ahead for antibiotics in 2019? 26 Dec 2018, https://www.acsh.org/news/
2018/12/26/whats-ahead-antibiotics-2019-13685, accessed 12 April, 2019
Silver LL (2014) Antibacterials for any target. Nat Biotech 32 (11):1102–1104
Sittampalam GS, Rudnicki DD, Tagle DA et al. (2019) Mapping biologically active chemical space
to accelerate drug discovery. Nat Rev Drug Discov 18 (2):83–84
Smith PA, Koehler MFT, Girgis HS et al. (2018) Optimized arylomycins are a new class of Gramnegative antibiotics. Nature 561 (7722):189–194
Sousa MC (2019) New antibiotics target the outer membrane of bacteria. Nature 576 (7787):389–390
Srinivas N, Jetter P, Ueberbacher BJ et al. (2010) Peptidomimetic antibiotics target outer-membrane
biogenesis in Pseudomonas aeruginosa. Science 327 (5968):1010–1013
Stevens M, Abdeen S, Salim N et al. (2019) HSP60/10 chaperonin systems are inhibited by a
variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem
Lett 29(9):1106–1112
Styles MJ, Blackwell HE (2018) Non-native autoinducer analogs capable of modulating the SdiA
quorum sensing receptor in Salmonella enterica serovar Typhimurium. Beilstein J Org Chem
14:2651–2664
Su C-C, Morgan CE, Kambakam S et al. (2019) Cryo-electron microscopy structure of an
Acinetobacter baumannii multidrug efflux pump. mBio 10 (4):e01295–01219
Tanaka T, Ikeya T, Kamoshida H et al. (2019) High-resolution protein 3D structure determination
in living eukaryotic cells. Angew Chem Int Ed 58 (22):7284–7288
Tanouchi Y, Lee AJ, Meredith H et al. (2013) Programmed cell death in bacteria and implications
for antibiotic therapy. Trends Microbiol 21 (6):265–270
Terra L, Dyson PJ, Hitchings MD et al. (2018) A novel alkaliphilic Streptomyces inhibits ESKAPE
pathogens. Front Microbiol 9:2458
Thaker MN, Wang W, Spanogiannopoulos P et al. (2013) Identifying producers of antibacterial
compounds by screening for antibiotic resistance. Nat Biotechnol 31 (10):922–927
Vetterli S, Zerbe K, Müller M et al. (2018) Thanatin targets the intermembrane protein complex
required for lipopolysaccharide transport in Escherichia coli. Sci Adv 4:eaau2634
Vickers CF, Silva APG, Chakraborty A et al. (2018) Structure-based design of MptpB inhibitors that
reduce multidrug-resistant Mycobacterium tuberculosis survival and infection burden in vivo. J
Med Chem 61 (18):8337–8352
Vu H, Pedro L, Mak T et al. (2018) Fragment-based screening of a natural product library against 62
potential malaria drug targets employing native mass spectrometry. ACS Infect Dis 4 (4):431–444
Walsh CT, Wencewicz TA (2014) Prospects for new antibiotics: a molecule-centered perspective. J
Antibiotic 67 (1):7–22
Wanted: a reward for antibiotic development (2018). Nat Biotechnol 36 (7):555
Wu G-Y, Shi X, Phan H et al. (2020) Efficient self-assembly of heterometallic triangular necklace
with strong antibacterial activity. Nat Commun 11 (1):3178
Yin Z, Wang Y, Whittell LR et al. (2014) DNA replication is the target for the antibacterial effects
of nonsteroidal anti-inflammatory drugs. Chem Biol 21 (4):481–487
York A (2020) New drugs for the antibacterial pipeline? Nat Rev Microbiol 18 (2):61–61
5 Future Possibilities
Schilling NA, Berscheid A, Schumacher J et al. (2019) Synthetic lugdunin analogues reveal essential
structural motifs for antimicrobial action and proton translocation capability. Angew Chem Int
Ed 58 (27):9234–9238
Schütz C, Empting M (2018) Targeting the Pseudomonas quinolone signal quorum sensing system
for the discovery of novel anti-infective pathoblockers. Beilstein J Org Chem 14:2627–2645
Segler MHS, Preuss M, Waller MP (2018) Planning chemical syntheses with deep neural networks
and symbolic AI. Nature 555 (7698):604–610
Shang Z, Winter JM, Kauffman CA et al. (2019) Salinipeptins: Integrated genomic and chemical approaches reveal unusual D-amino acid-containing ribosomally synthesized and posttranslationally modified peptides (RiPPs) from a Great Salt Lake Streptomyces sp. ACS Chem
Biol 14:415–425
Shlaes D (2018) What’s ahead for antibiotics in 2019? 26 Dec 2018, https://www.acsh.org/news/
2018/12/26/whats-ahead-antibiotics-2019-13685, accessed 12 April, 2019
Silver LL (2014) Antibacterials for any target. Nat Biotech 32 (11):1102–1104
Sittampalam GS, Rudnicki DD, Tagle DA et al. (2019) Mapping biologically active chemical space
to accelerate drug discovery. Nat Rev Drug Discov 18 (2):83–84
Smith PA, Koehler MFT, Girgis HS et al. (2018) Optimized arylomycins are a new class of Gramnegative antibiotics. Nature 561 (7722):189–194
Sousa MC (2019) New antibiotics target the outer membrane of bacteria. Nature 576 (7787):389–390
Srinivas N, Jetter P, Ueberbacher BJ et al. (2010) Peptidomimetic antibiotics target outer-membrane
biogenesis in Pseudomonas aeruginosa. Science 327 (5968):1010–1013
Stevens M, Abdeen S, Salim N et al. (2019) HSP60/10 chaperonin systems are inhibited by a
variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem
Lett 29(9):1106–1112
Styles MJ, Blackwell HE (2018) Non-native autoinducer analogs capable of modulating the SdiA
quorum sensing receptor in Salmonella enterica serovar Typhimurium. Beilstein J Org Chem
14:2651–2664
Su C-C, Morgan CE, Kambakam S et al. (2019) Cryo-electron microscopy structure of an
Acinetobacter baumannii multidrug efflux pump. mBio 10 (4):e01295–01219
Tanaka T, Ikeya T, Kamoshida H et al. (2019) High-resolution protein 3D structure determination
in living eukaryotic cells. Angew Chem Int Ed 58 (22):7284–7288
Tanouchi Y, Lee AJ, Meredith H et al. (2013) Programmed cell death in bacteria and implications
for antibiotic therapy. Trends Microbiol 21 (6):265–270
Terra L, Dyson PJ, Hitchings MD et al. (2018) A novel alkaliphilic Streptomyces inhibits ESKAPE
pathogens. Front Microbiol 9:2458
Thaker MN, Wang W, Spanogiannopoulos P et al. (2013) Identifying producers of antibacterial
compounds by screening for antibiotic resistance. Nat Biotechnol 31 (10):922–927
Vetterli S, Zerbe K, Müller M et al. (2018) Thanatin targets the intermembrane protein complex
required for lipopolysaccharide transport in Escherichia coli. Sci Adv 4:eaau2634
Vickers CF, Silva APG, Chakraborty A et al. (2018) Structure-based design of MptpB inhibitors that
reduce multidrug-resistant Mycobacterium tuberculosis survival and infection burden in vivo. J
Med Chem 61 (18):8337–8352
Vu H, Pedro L, Mak T et al. (2018) Fragment-based screening of a natural product library against 62
potential malaria drug targets employing native mass spectrometry. ACS Infect Dis 4 (4):431–444
Walsh CT, Wencewicz TA (2014) Prospects for new antibiotics: a molecule-centered perspective. J
Antibiotic 67 (1):7–22
Wanted: a reward for antibiotic development (2018). Nat Biotechnol 36 (7):555
Wu G-Y, Shi X, Phan H et al. (2020) Efficient self-assembly of heterometallic triangular necklace
with strong antibacterial activity. Nat Commun 11 (1):3178
Yin Z, Wang Y, Whittell LR et al. (2014) DNA replication is the target for the antibacterial effects
of nonsteroidal anti-inflammatory drugs. Chem Biol 21 (4):481–487
York A (2020) New drugs for the antibacterial pipeline? Nat Rev Microbiol 18 (2):61–61