114
3 Single Molecule Non-cleavable Multiply Active Antibacterials
Jin J-L, Hua G-q, Meng Z et al. (2010) Antibacterial mechanisms of berberine and reasons for little
resistance of bacteria. Chin Herb Med 3(1):27–35
Kalia VC (2013) Quorum sensing inhibitors: An overview. Biotechnol Adv 31:224–245.
Kapp E, Malan SF, Joubert J et al. (2018) Small molecule efflux pump inhibitors in Mycobacterium
tuberculosis: a rational drug design perspective. Mini Rev Med Chem 18 (1):72–86
Kaul G, Shukla M, Dasgupta A et al. (2019) Update on drug-repurposing: is it useful for tackling
antimicrobial resistance? Future Microbiol 14:829–831
Kim SH, Lee SJ, Lee JH et al. (2002) Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine
derivatives. Planta Med 68 (3):277–281
King TA, Stewart HL, Mortensen KT et al. (2019) Cycloaddition Strategies for the Synthesis of
Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery. Eur J Org Chem 2019
(31–32):5219–5229
Klahn P, Brönstrup M (2017) Bifunctional antimicrobial conjugates and hybrid antimicrobials. Nat
Prod Rep 34 (7):832–885
Kohnen-Johannsen KL, Kayser O (2019) Tropane alkaloids: Chemistry, pharmacology, biosynthesis
and production. Molecules 24(4):796
Koul A, Arnoult E, Lounis N et al. (2011) The challenge of new drug discovery for tuberculosis.
Nature 469 (7331):483–490
Kourtesi C, Ball AR, Huang YY et al. (2013) Microbial efflux systems and inhibitors: approaches
to drug discovery and the challenge of clinical implementation. Open Microbiol J 7(Suppl 1M3):34–52
Krämer K (2019) A wish list for organic chemistry. Chem World 16 (4):34–35
Kusuma KD, Griffith R, Harry EJ et al. (2019) In silico analysis of ftsz crystal structures towards a
new target for antibiotics. Aust J Chem 72:184–193
Kuznedelov K, Semenova E, Knappe TA et al. (2011) The antibacterial threaded-lasso peptide
capistruin inhibits bacterial RNA polymerase. J Mol Biol 412 (5):842–848
Lamut A, Mašiˇ c L, Kikelj D et al. (2019) Efflux pump inhibitors of clinically relevant multidrug
resistant bacteria. Med Res Rev 39:1–45
Lavrado J, Moreira R, Paulo A (2010) Indoloquinolines as scaffolds for drug discovery. Curr Med
Chem 17 (22):2348–2370
Lessa JA, Parrilha GL, Beraldo H (2012) Gallium complexes as new promising metallodrug
candidates. Inorganica Chim Acta 393:53–63
Li B, Wever WJ, Walsh CT et al. (2014) Dithiolopyrrolones: biosynthesis, synthesis, and activity
of a unique class of disulfide-containing antibiotics. Nat Prod Rep 31 (7):905–923
Li R, Wu J, He Y et al. (2014a) Synthesis and in vitro evaluation of 12-(substituted
aminomethyl)berberrubine derivatives as anti-diabetics. Bioorg Med Chem Lett 24:1762–1765
Li Y-H, Li Y, Yang P et al. (2010) Design, synthesis, and cholesterol-lowering efficacy for prodrugs
of berberrubine. Bioorg Med Chem 18 (17):6422–6428
Lin Z, Xu X, Zhao S et al. (2018) Total synthesis and antimicrobial evaluation of natural albomycins
against clinical pathogens. Nat Commun 9 (1):3445
Ling LL, Schneider T, Peoples AJ et al. (2015) A new antibiotic kills pathogens without detectable
resistance. Nature 517:455–459
Liu Z, Li J, Li S et al. (2018) SuFEx click chemistry enabled late-stage drug functionalization. J
Am Chem Soc 140:2919–2925
Livermore DM, Warner M, Mushtaq S et al. (2016). Interactions of OP0595, a novel tripleaction diazabicyclooctane, with β-lactams against OP0595-resistant Enterobacteriaceae mutants.
Antimicrob Agents Chemother 60(1): 554–560
Livermore DM, Mushtaq, S, Warner M et al. (2017) In vitro activity of cefepime/zidebactam (WCK
5222) against Gram-negative bacteria. J Antimicrob Chemother 72(5):1373–1385
Lo C-Y, Hsu L-C, Chen M-S et al. (2013) Synthesis and anti-cancer activity of a novel series of
9-O-substituted berberine derivatives: A lipophilic substitute role. Bioorg Med Chem Lett 23:
305–309
3 Single Molecule Non-cleavable Multiply Active Antibacterials
Jin J-L, Hua G-q, Meng Z et al. (2010) Antibacterial mechanisms of berberine and reasons for little
resistance of bacteria. Chin Herb Med 3(1):27–35
Kalia VC (2013) Quorum sensing inhibitors: An overview. Biotechnol Adv 31:224–245.
Kapp E, Malan SF, Joubert J et al. (2018) Small molecule efflux pump inhibitors in Mycobacterium
tuberculosis: a rational drug design perspective. Mini Rev Med Chem 18 (1):72–86
Kaul G, Shukla M, Dasgupta A et al. (2019) Update on drug-repurposing: is it useful for tackling
antimicrobial resistance? Future Microbiol 14:829–831
Kim SH, Lee SJ, Lee JH et al. (2002) Antimicrobial activity of 9-O-acyl- and 9-O-alkylberberrubine
derivatives. Planta Med 68 (3):277–281
King TA, Stewart HL, Mortensen KT et al. (2019) Cycloaddition Strategies for the Synthesis of
Diverse Heterocyclic Spirocycles for Fragment-Based Drug Discovery. Eur J Org Chem 2019
(31–32):5219–5229
Klahn P, Brönstrup M (2017) Bifunctional antimicrobial conjugates and hybrid antimicrobials. Nat
Prod Rep 34 (7):832–885
Kohnen-Johannsen KL, Kayser O (2019) Tropane alkaloids: Chemistry, pharmacology, biosynthesis
and production. Molecules 24(4):796
Koul A, Arnoult E, Lounis N et al. (2011) The challenge of new drug discovery for tuberculosis.
Nature 469 (7331):483–490
Kourtesi C, Ball AR, Huang YY et al. (2013) Microbial efflux systems and inhibitors: approaches
to drug discovery and the challenge of clinical implementation. Open Microbiol J 7(Suppl 1M3):34–52
Krämer K (2019) A wish list for organic chemistry. Chem World 16 (4):34–35
Kusuma KD, Griffith R, Harry EJ et al. (2019) In silico analysis of ftsz crystal structures towards a
new target for antibiotics. Aust J Chem 72:184–193
Kuznedelov K, Semenova E, Knappe TA et al. (2011) The antibacterial threaded-lasso peptide
capistruin inhibits bacterial RNA polymerase. J Mol Biol 412 (5):842–848
Lamut A, Mašiˇ c L, Kikelj D et al. (2019) Efflux pump inhibitors of clinically relevant multidrug
resistant bacteria. Med Res Rev 39:1–45
Lavrado J, Moreira R, Paulo A (2010) Indoloquinolines as scaffolds for drug discovery. Curr Med
Chem 17 (22):2348–2370
Lessa JA, Parrilha GL, Beraldo H (2012) Gallium complexes as new promising metallodrug
candidates. Inorganica Chim Acta 393:53–63
Li B, Wever WJ, Walsh CT et al. (2014) Dithiolopyrrolones: biosynthesis, synthesis, and activity
of a unique class of disulfide-containing antibiotics. Nat Prod Rep 31 (7):905–923
Li R, Wu J, He Y et al. (2014a) Synthesis and in vitro evaluation of 12-(substituted
aminomethyl)berberrubine derivatives as anti-diabetics. Bioorg Med Chem Lett 24:1762–1765
Li Y-H, Li Y, Yang P et al. (2010) Design, synthesis, and cholesterol-lowering efficacy for prodrugs
of berberrubine. Bioorg Med Chem 18 (17):6422–6428
Lin Z, Xu X, Zhao S et al. (2018) Total synthesis and antimicrobial evaluation of natural albomycins
against clinical pathogens. Nat Commun 9 (1):3445
Ling LL, Schneider T, Peoples AJ et al. (2015) A new antibiotic kills pathogens without detectable
resistance. Nature 517:455–459
Liu Z, Li J, Li S et al. (2018) SuFEx click chemistry enabled late-stage drug functionalization. J
Am Chem Soc 140:2919–2925
Livermore DM, Warner M, Mushtaq S et al. (2016). Interactions of OP0595, a novel tripleaction diazabicyclooctane, with β-lactams against OP0595-resistant Enterobacteriaceae mutants.
Antimicrob Agents Chemother 60(1): 554–560
Livermore DM, Mushtaq, S, Warner M et al. (2017) In vitro activity of cefepime/zidebactam (WCK
5222) against Gram-negative bacteria. J Antimicrob Chemother 72(5):1373–1385
Lo C-Y, Hsu L-C, Chen M-S et al. (2013) Synthesis and anti-cancer activity of a novel series of
9-O-substituted berberine derivatives: A lipophilic substitute role. Bioorg Med Chem Lett 23:
305–309