References
113
Gandini A, Bartolini M, Tedesco D et al. (2018) Tau-Centric multitarget approach for Alzheimer’s
disease: Development of first-in-class dual glycogen synthase kinase 3β and tau-aggregation
inhibitors. J Med Chem 61 (17):7640–7656
Gharbo SA, Beal JL, Doskotch RW et al. (1973) Alkaloids of Thalictrum. XIV. Isolation of alkaloids
having antimicrobial activity from Thalictrum polygamum. Lloydia 36 (3):349–351
Gorityala BK, Guchhait G, Goswami S et al. (2016) Hybrid antibiotic overcomes resistance in
P. aeruginosa by enhancing outer membrane penetration and reducing efflux. J Med Chem 59
(18):8441–8455
Górska A, Sloderbach A, Marszałł MP (2014) Siderophore–drug complexes: potential medicinal
applications of the ‘Trojan horse’ strategy. Trends Pharmacol Sci 35 (9):442–449
Grycová L, Dostál J, Marek R (2007) Quaternary protoberberine alkaloids. Phytochemistry 68
(2):150–175
Guerrera CA, Ryder TR (2016) The Petasis Borono-Mannich Multicomponent Reaction. In: Boron
Reagents in Synthesis, vol 1236. ACS Symposium Series, vol 1236. American Chemical Society,
pp 275–311
Guo D, Li J, Lin H et al. (2016) Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as selective α(1A)-adrenoceptor antagonists. J Med Chem 59
(20):9489–9502
Gupta V, Datta P (2019) Next-generation strategy for treating drug resistant bacteria: Antibiotic
hybrids. Indian J Med Res 149 (2):97–106
Gupta V, Gaur R, Sharma A et al. (2018) A novel bi-functional chalcone inhibits multi-drug resistant
Staphylococcus aureus and potentiates the activity of fluoroquinolones. Bioorg Chem 83:214–225
Hakobyan S, Boily J-F, Ramstedt M (2014) Proton and gallium(III) binding properties of a
biologically active salicylidene acylhydrazide. J Inorg Biochem 138:9–15
Han S, Zaniewski RP, Marr ES et al. (2010) Structural basis for effectiveness of siderophoreconjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. PNAS
107 (51):22002–22007
Harbut MB, Vilchèze C, Luo X et al. (2015) Auranofin exerts broad-spectrum bactericidal activities
by targeting thiol-redox homeostasis. Proc Natl Acad Sci 112(14):4453–4458
Ho TT, Tran QT, Chai CL (2018) The polypharmacology of natural products. Future Med Chem
10 (11):1361–1368
Hopkins AL (2009) Drug discovery: Predicting promiscuity. Nature 462 (7270):167–168
Islas R, Chamorro E, Robles J et al. (2007) Borazine: To be or not to be aromatic. Struct Chem
18:833–839
Ito A, Nishikawa T, Matsumoto S et al. (2016) Siderophore cephalosporin Cefiderocol utilizes ferric
iron transporter systems for antibacterial activity against Pseudomonas aeruginosa. Antimicrob
Agents Chemother 60 (12):7396–7401
Ito A, Sato T, Ota M et al. (2018) In vitro antibacterial properties of Cefiderocol, a novel siderophore
cephalosporin, against Gram-negative bacteria. Antimicrob Agents Chemother 62 (1):e01454–17
Ivanenkov YA,Yamidanov RS, Osterman IA et al. (2019a) 2-Pyrazol-1-yl-thiazole derivatives as
highly potent antibacterials. J Antibiot 72:827–833
Ivanenkov YA, Zhavoronkov A, Yamidanov RS et al. (2019b) Identification of novel antibacterials
using machine learning techniques. Front Pharmacol 10:913
Iwasa K, Nanba H, Lee DU et al. (1998) Structure-activity relationships of protoberberines having
antimicrobial activity. Planta Med 64 (8):748–751
Janas A, Przybylski P (2019) 14- and 15-Membered lactone macrolides and their analogues and
hybrids: structure, molecular mechanism of action and biological activity. Eur J Med Chem
182:111662
Jayaraman P, Sakharkar KR, Lim C et al. (2013) Novel phytochemical-antibiotic conjugates as
multitarget inhibitors of Pseudomonas aeruginosa GyrB/ParE and DHFR. Drug Des Dev Ther
7: 449–475
Jaye JA, Gelinas BS, McCormick GM et al. (2017) Implications of the final ring closure to 10baza-10c-borapyrene for aryl–alkyne ring-closing mechanisms. Can J Chem 95 (4):357–362
113
Gandini A, Bartolini M, Tedesco D et al. (2018) Tau-Centric multitarget approach for Alzheimer’s
disease: Development of first-in-class dual glycogen synthase kinase 3β and tau-aggregation
inhibitors. J Med Chem 61 (17):7640–7656
Gharbo SA, Beal JL, Doskotch RW et al. (1973) Alkaloids of Thalictrum. XIV. Isolation of alkaloids
having antimicrobial activity from Thalictrum polygamum. Lloydia 36 (3):349–351
Gorityala BK, Guchhait G, Goswami S et al. (2016) Hybrid antibiotic overcomes resistance in
P. aeruginosa by enhancing outer membrane penetration and reducing efflux. J Med Chem 59
(18):8441–8455
Górska A, Sloderbach A, Marszałł MP (2014) Siderophore–drug complexes: potential medicinal
applications of the ‘Trojan horse’ strategy. Trends Pharmacol Sci 35 (9):442–449
Grycová L, Dostál J, Marek R (2007) Quaternary protoberberine alkaloids. Phytochemistry 68
(2):150–175
Guerrera CA, Ryder TR (2016) The Petasis Borono-Mannich Multicomponent Reaction. In: Boron
Reagents in Synthesis, vol 1236. ACS Symposium Series, vol 1236. American Chemical Society,
pp 275–311
Guo D, Li J, Lin H et al. (2016) Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as selective α(1A)-adrenoceptor antagonists. J Med Chem 59
(20):9489–9502
Gupta V, Datta P (2019) Next-generation strategy for treating drug resistant bacteria: Antibiotic
hybrids. Indian J Med Res 149 (2):97–106
Gupta V, Gaur R, Sharma A et al. (2018) A novel bi-functional chalcone inhibits multi-drug resistant
Staphylococcus aureus and potentiates the activity of fluoroquinolones. Bioorg Chem 83:214–225
Hakobyan S, Boily J-F, Ramstedt M (2014) Proton and gallium(III) binding properties of a
biologically active salicylidene acylhydrazide. J Inorg Biochem 138:9–15
Han S, Zaniewski RP, Marr ES et al. (2010) Structural basis for effectiveness of siderophoreconjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa. PNAS
107 (51):22002–22007
Harbut MB, Vilchèze C, Luo X et al. (2015) Auranofin exerts broad-spectrum bactericidal activities
by targeting thiol-redox homeostasis. Proc Natl Acad Sci 112(14):4453–4458
Ho TT, Tran QT, Chai CL (2018) The polypharmacology of natural products. Future Med Chem
10 (11):1361–1368
Hopkins AL (2009) Drug discovery: Predicting promiscuity. Nature 462 (7270):167–168
Islas R, Chamorro E, Robles J et al. (2007) Borazine: To be or not to be aromatic. Struct Chem
18:833–839
Ito A, Nishikawa T, Matsumoto S et al. (2016) Siderophore cephalosporin Cefiderocol utilizes ferric
iron transporter systems for antibacterial activity against Pseudomonas aeruginosa. Antimicrob
Agents Chemother 60 (12):7396–7401
Ito A, Sato T, Ota M et al. (2018) In vitro antibacterial properties of Cefiderocol, a novel siderophore
cephalosporin, against Gram-negative bacteria. Antimicrob Agents Chemother 62 (1):e01454–17
Ivanenkov YA,Yamidanov RS, Osterman IA et al. (2019a) 2-Pyrazol-1-yl-thiazole derivatives as
highly potent antibacterials. J Antibiot 72:827–833
Ivanenkov YA, Zhavoronkov A, Yamidanov RS et al. (2019b) Identification of novel antibacterials
using machine learning techniques. Front Pharmacol 10:913
Iwasa K, Nanba H, Lee DU et al. (1998) Structure-activity relationships of protoberberines having
antimicrobial activity. Planta Med 64 (8):748–751
Janas A, Przybylski P (2019) 14- and 15-Membered lactone macrolides and their analogues and
hybrids: structure, molecular mechanism of action and biological activity. Eur J Med Chem
182:111662
Jayaraman P, Sakharkar KR, Lim C et al. (2013) Novel phytochemical-antibiotic conjugates as
multitarget inhibitors of Pseudomonas aeruginosa GyrB/ParE and DHFR. Drug Des Dev Ther
7: 449–475
Jaye JA, Gelinas BS, McCormick GM et al. (2017) Implications of the final ring closure to 10baza-10c-borapyrene for aryl–alkyne ring-closing mechanisms. Can J Chem 95 (4):357–362