112
3 Single Molecule Non-cleavable Multiply Active Antibacterials
Cheng J, Thanassi JA, Thoma CL et al. (2007) Dual targeting of DNA gyrase and topoisomerase
IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. Antimicrob Agents
Chemother 51 (7):2445–2453
Cheng P, Wang B, Liu X et al. (2014) Facile synthesis of tetrahydroberberine and protoberberine
alkaloids from protopines and study on their antibacterial activities. Nat Prod Res 28(7):413–419
Cheng Z, Chen A-F, Wu F et al. (2010) 8,8-Dimethyldihydroberberine with improved bioavailability
and oral efficacy on obese and diabetic mouse models. Bioorg Med Chem 18:5915–5924
Colomer I, Empson CJ, Craven P et al. (2016) A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool.
ChemComm 52 (45):7209–7212
Costa SS, Viveiros M, Amaral L et al. (2013) Multidrug efflux pumps in Staphylococcus aureus:
an update. Open Microbiol J 7:59–71
Dateer RB, Shaibu B, Liu R-S (2012) Gold-catalyzed intermolecular [4+2] cycloadditions of
ynamides with alkenes. Angew Chem Int Ed 51:113–117
Dean CR, Barkan DT, Bermingham A et al. (2018) Mode of action of the monobactam LYS228 and
mechanisms decreasing in vitro susceptibility in Escherichia coli and Klebsiella pneumoniae.
Antimicrob Agents Chemother 62 (10):e01200–18
Decker M (2017) Introduction. In: Decker M (ed) Design of hybrid molecules for drug development.
Elsevier, Amsterdam, pp 1–3
DeCorte B, Russcher JC, Monnee MCF (2018) Therapeutic compounds for pain and synthesis
thereof. US Patent 10,040,795 B2, 7 Aug 2018
Decuyper L, Jukiˇ c M, Sosiˇ c I et al. (2018) Antibacterial and β-lactamase inhibitory activity of
monocyclic β-lactams. Med Res Rev 38 (2):426–503
DeGoey DA, Chen HJ, Cox PB et al. (2018) Beyond the rule of 5: lessons learned from AbbVie’s
drugs and compound collection. J Med Chem 61 (7):2636–2651
Dolla N, Chen C, Larkins-Ford, J et al. (2014) On the mechanism of berberine-INF55 (5-nitro-2phenylindole) hybrid antibacterials. Aust J Chem. 67:1471–1480
Domadia PN, Bhunia, A, Sivaraman J et al. (2008) Berberine targets assembly of Escherichia coli
cell division protein FtsZ. Biochem 47(10): 3225–3234
Domalaon R, Idowu T, Zhanel GG et al. (2018) Antibiotic hybrids: the next generation of agents
and adjuvants against Gram-negative pathogens? Clin Microbiol Rev 31 (2):e00077–00017
East SP, Silver LL (2013) Multitarget ligands in antibacterial research: progress and opportunities.
Expert Opin Drug Discov 8 (2):143–156
Edwards MJ, Flatman RH, Mitchenall LA et al. (2009). A crystal structure of the bifunctional
antibiotic simocyclinone D8, bound to DNA gyrase. Science 326:1415–1418
Eijkelkamp BA, McDevitt CA, Kitten T (2015) Manganese uptake and streptococcal virulence.
Biometals 28 (3):491–508
Etukala JR, Kumar EVKS, Ablordeppey SY (2008) A short and convenient synthesis and evaluation
of the antiinfective properties of indoloquinoline alkaloids: 10H-Indolo[3,2-b]quinoline and 7Hindolo[2,3-c]quinolines. J Het Chem 45 (2):507–512
Fan T, Guo X, Zeng Q et al. (2020) Synthesis and structure-activity relationship of palmatine
derivatives as a novel class of antibacterial agents against Helicobacter pylori. Molecules 25:1352
Farha MA, Brown ED (2019) Drug repurposing for antimicrobial discovery. Nat Microbiol 4
(4):565–577
Fedorowicz J, S˛ aczewski J (2018) Modifications of quinolones and fluoroquinolones: hybrid
compounds and dual-action molecules. Monatsh Chem 149 (7):1199–1245
Foley DJ, Craven PGE, Collins PM et al. (2017) Synthesis and demonstration of the biological
relevance of sp(3) -rich scaffolds distantly related to natural product frameworks. Chem Eur J 23
(60):15227–15232
Fujita K-i, Enoki Y, Yamaguchi R (2008) Cp*Ir-catalyzed N-alkylation of amines with alcohols. A
versatile and atom economical method for the synthesis of amines. Tetrahedron 64:1943–1954
Gallardo-Godoy A, Hansford KA, Muldoon C et al. (2019) Structure-Function Studies of Polymyxin
B Lipononapeptides. Molecules 24 (3):553
3 Single Molecule Non-cleavable Multiply Active Antibacterials
Cheng J, Thanassi JA, Thoma CL et al. (2007) Dual targeting of DNA gyrase and topoisomerase
IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus. Antimicrob Agents
Chemother 51 (7):2445–2453
Cheng P, Wang B, Liu X et al. (2014) Facile synthesis of tetrahydroberberine and protoberberine
alkaloids from protopines and study on their antibacterial activities. Nat Prod Res 28(7):413–419
Cheng Z, Chen A-F, Wu F et al. (2010) 8,8-Dimethyldihydroberberine with improved bioavailability
and oral efficacy on obese and diabetic mouse models. Bioorg Med Chem 18:5915–5924
Colomer I, Empson CJ, Craven P et al. (2016) A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool.
ChemComm 52 (45):7209–7212
Costa SS, Viveiros M, Amaral L et al. (2013) Multidrug efflux pumps in Staphylococcus aureus:
an update. Open Microbiol J 7:59–71
Dateer RB, Shaibu B, Liu R-S (2012) Gold-catalyzed intermolecular [4+2] cycloadditions of
ynamides with alkenes. Angew Chem Int Ed 51:113–117
Dean CR, Barkan DT, Bermingham A et al. (2018) Mode of action of the monobactam LYS228 and
mechanisms decreasing in vitro susceptibility in Escherichia coli and Klebsiella pneumoniae.
Antimicrob Agents Chemother 62 (10):e01200–18
Decker M (2017) Introduction. In: Decker M (ed) Design of hybrid molecules for drug development.
Elsevier, Amsterdam, pp 1–3
DeCorte B, Russcher JC, Monnee MCF (2018) Therapeutic compounds for pain and synthesis
thereof. US Patent 10,040,795 B2, 7 Aug 2018
Decuyper L, Jukiˇ c M, Sosiˇ c I et al. (2018) Antibacterial and β-lactamase inhibitory activity of
monocyclic β-lactams. Med Res Rev 38 (2):426–503
DeGoey DA, Chen HJ, Cox PB et al. (2018) Beyond the rule of 5: lessons learned from AbbVie’s
drugs and compound collection. J Med Chem 61 (7):2636–2651
Dolla N, Chen C, Larkins-Ford, J et al. (2014) On the mechanism of berberine-INF55 (5-nitro-2phenylindole) hybrid antibacterials. Aust J Chem. 67:1471–1480
Domadia PN, Bhunia, A, Sivaraman J et al. (2008) Berberine targets assembly of Escherichia coli
cell division protein FtsZ. Biochem 47(10): 3225–3234
Domalaon R, Idowu T, Zhanel GG et al. (2018) Antibiotic hybrids: the next generation of agents
and adjuvants against Gram-negative pathogens? Clin Microbiol Rev 31 (2):e00077–00017
East SP, Silver LL (2013) Multitarget ligands in antibacterial research: progress and opportunities.
Expert Opin Drug Discov 8 (2):143–156
Edwards MJ, Flatman RH, Mitchenall LA et al. (2009). A crystal structure of the bifunctional
antibiotic simocyclinone D8, bound to DNA gyrase. Science 326:1415–1418
Eijkelkamp BA, McDevitt CA, Kitten T (2015) Manganese uptake and streptococcal virulence.
Biometals 28 (3):491–508
Etukala JR, Kumar EVKS, Ablordeppey SY (2008) A short and convenient synthesis and evaluation
of the antiinfective properties of indoloquinoline alkaloids: 10H-Indolo[3,2-b]quinoline and 7Hindolo[2,3-c]quinolines. J Het Chem 45 (2):507–512
Fan T, Guo X, Zeng Q et al. (2020) Synthesis and structure-activity relationship of palmatine
derivatives as a novel class of antibacterial agents against Helicobacter pylori. Molecules 25:1352
Farha MA, Brown ED (2019) Drug repurposing for antimicrobial discovery. Nat Microbiol 4
(4):565–577
Fedorowicz J, S˛ aczewski J (2018) Modifications of quinolones and fluoroquinolones: hybrid
compounds and dual-action molecules. Monatsh Chem 149 (7):1199–1245
Foley DJ, Craven PGE, Collins PM et al. (2017) Synthesis and demonstration of the biological
relevance of sp(3) -rich scaffolds distantly related to natural product frameworks. Chem Eur J 23
(60):15227–15232
Fujita K-i, Enoki Y, Yamaguchi R (2008) Cp*Ir-catalyzed N-alkylation of amines with alcohols. A
versatile and atom economical method for the synthesis of amines. Tetrahedron 64:1943–1954
Gallardo-Godoy A, Hansford KA, Muldoon C et al. (2019) Structure-Function Studies of Polymyxin
B Lipononapeptides. Molecules 24 (3):553