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use of phytochemicals as new antimicrobial agents. Curr Med Chem 22 (21):2590–2614
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Dis 6:1332–1345
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Caliceti C, Franco P, Spinozzi S et al. (2016) Berberine: New insights from pharmacological aspects
to clinical evidences in the management of metabolic disorders. Curr Med Chem 23 (14):1460–
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Casiraghi A, Suigo L, Valoti E et al. (2020) Targeting bacterial cell division: A binding site-centered
approach to the most promising inhibitors of the essential protein FtsZ. Antibiotics 9 (2):69
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Blaskovich MAT, Pitt ME, Elliott AG et al. (2018b) Can octapeptin antibiotics combat extensively
drug-resistant (XDR) bacteria? Expert Rev Anti Infect Ther 16 (6):485–499
Boberek, J. M., Stach, J., and Good, L. 2010. Genetic evidence for inhibition of bacterial division
protein FtsZ by berberine. PloS One 5(10): e13745
Bogányi B, Kámán J (2013) A concise synthesis of indoloquinoline skeletons applying two
consecutive Pd-catalyzed reactions. Tetrahedron 69 (45):9512–9519
Bolognesi M L (2013) Polypharmacology in a single drug: Multitarget drugs. Curr Med Chem 20:
1639–1645.
Bolognesi M L (2019) Harnessing polypharmacology with medicinal chemistry. ACS Med Chem
Lett 10:273–275
Borges A, Saavedra MJ, Simões M (2015) Insights on antimicrobial resistance, biofilms and the
use of phytochemicals as new antimicrobial agents. Curr Med Chem 22 (21):2590–2614
Bradford PA, Miller AA, O’Donnell et al. (2020) Zoliflodacin: An oral spiropyrimidinetrione antibiotic for the treatment of Neisseria gonorrheae, including multi-drug-resistant isolates. ACS Infect
Dis 6:1332–1345
Breda S, Reva ID, Lapinski L et al. (2006) Infrared spectra of pyrazine, pyrimidine and pyridazine
in solid argon. J Mol Struct 786 (2):193–206
Bremner JB, Browne EJ, Gunawardana IWK (1982) Oxaza and dioxaza medium-sized heterocycles
and benz-fused derivatives. Heterocycles 19 (4):709–742
Bremner JB, Smith RJ, Tarrant GJ (1996) A Meisenheimer rearrangement approach to bridgehead
hydroxylated tropane alkaloid derivatives. Tetrahedron Lett 37(1):97–100
Bremner JB, Ambrus JI, Samosorn S (2007) Dual-action based approaches to antibacterial agents.
Curr Med Chem 14(13):1459–1477
Bremner JB, Keller PA, Pyne SG et al. (2010a) Binaphthyl-based dicationic peptoids with
therapeutic potential. Angew Chem Int Ed 49:537–540
Bremner JB, Kelso MJ (2010b) Synthesis of berberine-efflux pump inhibitor hybrid antibacterials.
Synth Commun 40 (23):3561–3568
Bremner JB (2017) Molecular design of potential triple-action antibacterial agents and related
pro-drugs. SWU Sci J 33 (1):1–19
Brötz-Oesterhelt H, Brunner NA (2008) How many modes of action should an antibiotic have? Curr
Opin Pharmacol 8 (5):564–573
Brown MF, Mitton-Fry MJ, Arcari JT et al. (2013) Pyridone-conjugated monobactam antibiotics
with Gram-negative activity. J Med Chem 56 (13):5541–5552
Buege MJ, Brown JE, Aitken SL (2017) Solithromycin: A novel ketolide antibiotic. Am J HealthSyst Pharm 74(12):875–887
Caliceti C, Franco P, Spinozzi S et al. (2016) Berberine: New insights from pharmacological aspects
to clinical evidences in the management of metabolic disorders. Curr Med Chem 23 (14):1460–
1476
Casiraghi A, Suigo L, Valoti E et al. (2020) Targeting bacterial cell division: A binding site-centered
approach to the most promising inhibitors of the essential protein FtsZ. Antibiotics 9 (2):69
CenterWatch (2019) FDA-approved drugs-CenterWatch; Infections and infectious diseases; Xenleta
(lefamulin). https://www.centrewatch.com/drug-information/fda-approved-drugs/. Accessed 19
December 2020
Chan A, Shiver A, Wever W et al. (2017) Role for dithiolopyrrolones in disrupting bacterial metal
homeostasis. Proc Natl Acad Sci USA 114 (10):2717–2722
Charrier C, Salisbury AM, Savage V J et al. (2017) Novel bacterial topoisomerase inhibitors with
potent broad-spectrum activity against drug-resistant bacteria. Antimicrob Agents Chemother
61(5):e02100–16
Chen J, Wang T, Xu S et al. (2017) Design, synthesis and biological evaluation of novel nitric
oxide-donating protoberberine derivatives as antitumor agents. Eur J Med Chem 132:173–183
Chen R, Zhang H, Ma T et al. (2019) Ciprofloxacin-1,2,3-triazole-isatin hybrids tethered via amide:
Design, synthesis, and in vitro anti-mycobacterial activity evaluation. Bioorg Med Chem Lett 29
(18):2635–2637