110
3 Single Molecule Non-cleavable Multiply Active Antibacterials
Alcaide MM, Santos FMF, Pais VF et al. (2017) Electronic and functional scope of boronic
acid derived salicylidenehydrazone (BASHY) complexes as fluorescent dyes. J Org Chem 82
(14):7151–7158
Amaral L, Martins A, Spengler G et al. (2014) Efflux pumps of Gram-negative bacteria: what they
do, how they do it, with what and how to deal with them. Front Pharmacol 4:168–168
Ambrus JI, Kelso MJ, Bremner JB et al. (2008) Structure-activity relationships of 2-aryl-1H-indole
inhibitors of the NorA efflux pump in Staphylococcus aureus. Bioorg Med Chem Lett 18:4294–
4297
Anusuya S, Natarajan J (2012) Multi-targeted therapy for leprosy: in silico strategy to overcome
multi drug resistance and to improve therapeutic efficacy. Infect Genet Evol 12 (8):1899–1910
Aoki T, Yoshizawa H, Yamawaki K et al. (2018) Cefiderocol (S-649266), A new siderophore
cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gramnegative pathogens including multi-drug resistant bacteria: Structure activity relationship. Eur
J Med Chem 155:847–868
Aparna V, Dineshkumar K, Mohanalakshmi N et al. (2014) Identification of natural compound
inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using in
silico high-throughput virtual screening and in vitro validation. PloS One 9 (7):e101840
Aswathanarayan JB, Vittal RR (2018) Inhibition of biofilm formation and quorum sensing mediated
phenotypes by berberine in Pseudomonas aeruginosa and Salmonella typhimurium. RSC Adv
8:36133–36141
Baell JB, Holloway GA (2010) New substructure filters for removal of pan assay interference
compounds (PAINS) from screening libraries and for their exclusion in bioassays. J Med Chem
53:2719–2740
Baell JB (2016) Feeling nature’s PAINS: Natural products, natural product drugs, and pan asay
interference compounds (PAINS). J Nat Prod 79(3):616–628
Baell JB, Nissink JWM (2018) Seven year itch: Pan-assay interference compounds (PAINS) in
2017-utility and limitations. ACS Chem Biol 13:36–44
Bai Y-B, Luo Z, Wang Y et al. (2018) Au-catalyzed intermolecular [2+2] cycloadditions between
chloroalkynes and unactivated alkenes. J Am Chem Soc 140:5860–5865
Ball AR, Casadei G, Samosorn S et al. (2006) Conjugating Berberine to a Multidrug Resistance
Pump Inhibitor Creates an Effective Antimicrobial. ACS Chemical Biology 1 (9):594–600
Barrow AS, Smedley CJ, Zheng Q et al. (2019) The growing applications of SuFEx click chemistry.
Chem Soc Rev 48 (17):4731–4758
Batra N, Rajendran V, Agarwal D et al. (2018) Synthesis and Antimalarial Evaluation of [1, 2,3]Triazole-Tethered Sulfonamide-Berberine Hybrids. ChemistrySelect 3:9790–9793
Ben W, Qiaoyun Z, Wenzhu Y et al. (2018) In-vitro characterisation of a novel antimicrobial agent,
TNP-2092, against Helicobacter pylori clinical isolates. Swiss Med Wkly 148:w114630
Beno BR, Yeung K-S, Bartberger MD et al. (2015) A survey of the role of noncovalent sulfur
interactions in drug design. J Med Chem 58 (11):4383–4438
Beppler C, Tekin E, Mao Z et al. (2016) Uncovering emergent interactions in three-way
combinations of stressors. J R Soc Interface 13 (125)
Besnard J, Ruda GF, Setola V et al. (2012) Automated design of ligands to polypharmacological
profiles. Nature 492 (7428):215–220
Bhowmik D, Buzzetti F, Fiorillo G et al. (2014) Synthesis of new 13-diphenylalkyl analogues
of berberine and elucidation of their base pair specificity and energetics of DNA binding.
MedChemComm 5 (2):226–231
Blanco P, Hernando-Amado S, Reales-Calderon JA et al. (2016) Bacterial multidrug efflux pumps:
much more than antibiotic resistance determinants. Microorganisms 4 (1):14
Blanco P, Sanz-García F, Hernando-Amado S et al. (2018) The development of efflux pump
inhibitors to treat Gram-negative infections. Expert Opin Drug Discov 13 (10):919–931
Blaskovich MAT, Hansford KA, Gong Y et al. (2018a) Protein-inspired antibiotics active against
vancomycin- and daptomycin-resistant bacteria. Nat Commun 9 (1):22
3 Single Molecule Non-cleavable Multiply Active Antibacterials
Alcaide MM, Santos FMF, Pais VF et al. (2017) Electronic and functional scope of boronic
acid derived salicylidenehydrazone (BASHY) complexes as fluorescent dyes. J Org Chem 82
(14):7151–7158
Amaral L, Martins A, Spengler G et al. (2014) Efflux pumps of Gram-negative bacteria: what they
do, how they do it, with what and how to deal with them. Front Pharmacol 4:168–168
Ambrus JI, Kelso MJ, Bremner JB et al. (2008) Structure-activity relationships of 2-aryl-1H-indole
inhibitors of the NorA efflux pump in Staphylococcus aureus. Bioorg Med Chem Lett 18:4294–
4297
Anusuya S, Natarajan J (2012) Multi-targeted therapy for leprosy: in silico strategy to overcome
multi drug resistance and to improve therapeutic efficacy. Infect Genet Evol 12 (8):1899–1910
Aoki T, Yoshizawa H, Yamawaki K et al. (2018) Cefiderocol (S-649266), A new siderophore
cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gramnegative pathogens including multi-drug resistant bacteria: Structure activity relationship. Eur
J Med Chem 155:847–868
Aparna V, Dineshkumar K, Mohanalakshmi N et al. (2014) Identification of natural compound
inhibitors for multidrug efflux pumps of Escherichia coli and Pseudomonas aeruginosa using in
silico high-throughput virtual screening and in vitro validation. PloS One 9 (7):e101840
Aswathanarayan JB, Vittal RR (2018) Inhibition of biofilm formation and quorum sensing mediated
phenotypes by berberine in Pseudomonas aeruginosa and Salmonella typhimurium. RSC Adv
8:36133–36141
Baell JB, Holloway GA (2010) New substructure filters for removal of pan assay interference
compounds (PAINS) from screening libraries and for their exclusion in bioassays. J Med Chem
53:2719–2740
Baell JB (2016) Feeling nature’s PAINS: Natural products, natural product drugs, and pan asay
interference compounds (PAINS). J Nat Prod 79(3):616–628
Baell JB, Nissink JWM (2018) Seven year itch: Pan-assay interference compounds (PAINS) in
2017-utility and limitations. ACS Chem Biol 13:36–44
Bai Y-B, Luo Z, Wang Y et al. (2018) Au-catalyzed intermolecular [2+2] cycloadditions between
chloroalkynes and unactivated alkenes. J Am Chem Soc 140:5860–5865
Ball AR, Casadei G, Samosorn S et al. (2006) Conjugating Berberine to a Multidrug Resistance
Pump Inhibitor Creates an Effective Antimicrobial. ACS Chemical Biology 1 (9):594–600
Barrow AS, Smedley CJ, Zheng Q et al. (2019) The growing applications of SuFEx click chemistry.
Chem Soc Rev 48 (17):4731–4758
Batra N, Rajendran V, Agarwal D et al. (2018) Synthesis and Antimalarial Evaluation of [1, 2,3]Triazole-Tethered Sulfonamide-Berberine Hybrids. ChemistrySelect 3:9790–9793
Ben W, Qiaoyun Z, Wenzhu Y et al. (2018) In-vitro characterisation of a novel antimicrobial agent,
TNP-2092, against Helicobacter pylori clinical isolates. Swiss Med Wkly 148:w114630
Beno BR, Yeung K-S, Bartberger MD et al. (2015) A survey of the role of noncovalent sulfur
interactions in drug design. J Med Chem 58 (11):4383–4438
Beppler C, Tekin E, Mao Z et al. (2016) Uncovering emergent interactions in three-way
combinations of stressors. J R Soc Interface 13 (125)
Besnard J, Ruda GF, Setola V et al. (2012) Automated design of ligands to polypharmacological
profiles. Nature 492 (7428):215–220
Bhowmik D, Buzzetti F, Fiorillo G et al. (2014) Synthesis of new 13-diphenylalkyl analogues
of berberine and elucidation of their base pair specificity and energetics of DNA binding.
MedChemComm 5 (2):226–231
Blanco P, Hernando-Amado S, Reales-Calderon JA et al. (2016) Bacterial multidrug efflux pumps:
much more than antibiotic resistance determinants. Microorganisms 4 (1):14
Blanco P, Sanz-García F, Hernando-Amado S et al. (2018) The development of efflux pump
inhibitors to treat Gram-negative infections. Expert Opin Drug Discov 13 (10):919–931
Blaskovich MAT, Hansford KA, Gong Y et al. (2018a) Protein-inspired antibiotics active against
vancomycin- and daptomycin-resistant bacteria. Nat Commun 9 (1):22