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Lowe RA, Taylor D, Chibale K et al. (2020) Synthesis and evaluation of the performance of a small
molecule library based on diverse tropane-related scaffolds. Bioorg Med Chem 28 (9):115442
Ma Z, Lynch AS (2016) Development of a dual-acting antibacterial agent (TNP-2092) for the
treatment of persistent bacterial infections. J Med Chem 59 (14):6645–6657
Mahjour B, Shen Y, Liu W et al. (2020) A map of the amine–carboxylic acid coupling system.
Nature 580 (7801):71–75
Mahmood HY, Jamshidi S, Sutton JM et al. (2016) Current advances in developing inhibitors of
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Maianti JP, Hanessian S (2016) Structural hybridization of three aminoglycoside antibiotics yields a
potent broad-spectrum bactericide that eludes bacterial resistance enzymes. Med Chem Commun
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Aliphatic rings, chirality, and sp 3 centers enhance target selectivity. Front Pharmacol 8:552
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Med Chem 49 (16):4961–4970
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Heterocycles 87 (1): 1–29
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115
Lovering F, Bikker J, Humblet C (2009) Escape from flatland: Increasing saturation as an approach
to improving clinical success. J Med Chem 52 (21):6752–6756
Lowe RA, Taylor D, Chibale K et al. (2020) Synthesis and evaluation of the performance of a small
molecule library based on diverse tropane-related scaffolds. Bioorg Med Chem 28 (9):115442
Ma Z, Lynch AS (2016) Development of a dual-acting antibacterial agent (TNP-2092) for the
treatment of persistent bacterial infections. J Med Chem 59 (14):6645–6657
Mahjour B, Shen Y, Liu W et al. (2020) A map of the amine–carboxylic acid coupling system.
Nature 580 (7801):71–75
Mahmood HY, Jamshidi S, Sutton JM et al. (2016) Current advances in developing inhibitors of
bacterial multidrug efflux pumps. Curr Med Chem 23 (10):1062–1081
Maianti JP, Hanessian S (2016) Structural hybridization of three aminoglycoside antibiotics yields a
potent broad-spectrum bactericide that eludes bacterial resistance enzymes. Med Chem Commun
7:170–176
Mari G, De Crescentini L, Benedetti S et al. (2020) Synthesis of new dihydroberberine and tetrahydroberberine analogues and evaluation of their antiproliferative activity on NCI-H1975 cells.
Beilstein J Org Chem 16:1606–1616
Martin JK, 2nd, Sheehan JP, Bratton BP et al. (2020) A dual-mechanism antibiotic kills Gramnegative bacteria and avoids drug resistance. Cell 181 (7):1518–1532
Meanwell NA (2011) Synopsis of some recent tactical application of bioisosteres in drug design. J
Med Chem 54 (8):2529–2591
Mehedi MAU, Molla A, Khondkar P et al. (2010) Pseurotin A: An antibacterial secondary metabolite
from Aspergillus fumigatus. Asian J Chem 22:2611–2614
Millan M (2009) Dual- and triple-acting agents for treating core and co-morbid symptoms of major
depression: novel concepts, new drugs. Neurotherapeutics 6 (1):53–77
Miller M, Zhu H, Xu Y et al. (2009) Utilization of microbial iron assimilation processes for the
development of new antibiotics and inspiration for the design of new anticancer agents. Biometals
22:61–75
Mishra SK, Tripathi G, Kishore N et al. (2017) Drug development against tuberculosis: Impact of
alkaloids. Eur J Med Chem 137: 504–544
Mistry B, Patel RV, Keum Y-S et al. (2017) Synthesis of N-Mannich bases of linking piperazine
moieties revealing anticancer and antioxidant effects. Saudi J Biol Sci 24:36–44
Monteleone S, Fuchs JE, Liedl KR (2017) Molecular connectivity predefines polypharmacology:
Aliphatic rings, chirality, and sp 3 centers enhance target selectivity. Front Pharmacol 8:552
Morgentin R, Dow M, Aimon A et al. (2018) Translation of innovative chemistry into screening
libraries: an exemplar partnership from the European Lead Factory. Drug Discov Today 23
(9):1578–1583
Morinaka A, Tsutsumi Y, Yamada M et al. 2015. OP0595, a new diazabicyclooctane: Mode of action
as a serine β-lactamase inhibitor, antibiotic and β-lactam ‘enhancer’. J Antimicrob Chemother
70(10): 2779–2786
Mori-Quiroz LM, Hedrick SL, De Los Santos AR et al. (2018) A unified strategy for the syntheses of
the isoquinolinium alkaloids berberine, coptisine, and jatrorrhizine. Org Lett 20 (14):4281–4284
Morphy R, Rankovic Z (2006) The physicochemical challenges of designing multiple ligands. J
Med Chem 49 (16):4961–4970
Mosaei H, Molodtsov V, Kepplinger B et al. (2018) Mode of action of kanglemycin A, an ansamycin
natural product that is active against rifampicin-resistant Mycobacterium tuberculosis. Mol Cell
72:263–274
Murphy AC, Gao S-S, Han L-C et al. (2014) Biosynthesis of thiomarinol A and related metabolites
of Pseudoalteromonas sp. SANK 73390. Chem Sci 5 (1):397–402
Nagao Y (2013) Chemical pharma-sciences that incorporate non-covalent bonded interactions.
Heterocycles 87 (1): 1–29
Nagao Y, Ilmori H, Nam KH et al. (2001) Synthesis and antibacterial activity of new 1bMethylcarbapenems having the potential for intramolecular nonbonded S···O interactions. Chem
Pharm Bull 49 (12):1660–1661