100
3 Single Molecule Non-cleavable Multiply Active Antibacterials
Fig. 3.26 Hybrid structure proposals from 8-oxodihydroberberine (a) and a related boronsubstituted analogue (b)
Scheme 3.3 Potential route to boron-based type (i) hybrids
A related boron-nitrogen framework for type (i) trihybrid design is that shown
in the product from the reaction of a substituted bis-imine with an arylboronic acid
(Scheme 3.3). This product type also allows for fluorescent variants to potentially
afford access to more detailed target tracking. Such compounds are based on those
described by Alcaide et al. (2017) and the synthesis should accommodate a range of
pharmacophoric groups for different bacterial target sites.
3.3.4.3 Type II. A---BC
This type is distinguished by only one multi-atom linking group being present
between A and BC, with the other two recognition units B and C being connected via
systems with a common atom in a ring, or at least two common atoms in fused rings,
3 Single Molecule Non-cleavable Multiply Active Antibacterials
Fig. 3.26 Hybrid structure proposals from 8-oxodihydroberberine (a) and a related boronsubstituted analogue (b)
Scheme 3.3 Potential route to boron-based type (i) hybrids
A related boron-nitrogen framework for type (i) trihybrid design is that shown
in the product from the reaction of a substituted bis-imine with an arylboronic acid
(Scheme 3.3). This product type also allows for fluorescent variants to potentially
afford access to more detailed target tracking. Such compounds are based on those
described by Alcaide et al. (2017) and the synthesis should accommodate a range of
pharmacophoric groups for different bacterial target sites.
3.3.4.3 Type II. A---BC
This type is distinguished by only one multi-atom linking group being present
between A and BC, with the other two recognition units B and C being connected via
systems with a common atom in a ring, or at least two common atoms in fused rings,