Human Endogenous Natural Products
335
20. Lee SP, Lester R, Pyrek JS (1987) Vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic
acid): a novel bile acid of a marsupial, Trichosurus vulpecula (Lesson). J Lipid Res 28:19
21. Roda A, Grigolo B, Minutello A, Pellicciari R, Natalini B (1990) Physicochemical and biological properties of natural and synthetic C-22 and C-23 hydroxylated bile acids. J Lipid Res
31:289
22. Hylemon PB, Melone PD, Franklund CV, Lund E, Björkhem I (1991) Mechanism of intestinal
7α-dehydroxylation of cholic acid: evidence that allo-deoxycholic acid is an inducible sideproduct. J Lipid Res 32:89
23. Craciun S, Balskus EP (2012) Microbial conversion of choline to trimethylamine requires a
glycyl radical enzyme. Proc Natl Acad Sci USA 109:21307
24. Wang Z, Roberts AB, Buffa JA, Levison BF, Zhu W, Org E, Gu X, Huang Y, ZamanianDaryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ,
Hazen SL (2015) Non-lethal inhibition of gut microbial trimethylamine production for the
treatment of atherosclerosis. Cell 163:1585
25. Dorrestein PC, Mazmanian SK, Knight R (2014) From microbiomess to metabolomes to
function during host-microbial interactions. Immunity 40:824
26. Dettmer K, Aronov PA, Hammock BD (2007) Mass spectrometry-based metabolomics. Mass
Spectrom Rev 26:51
27. Dunn WB, Broadhurst DI, Atherton HJ, Goodacre R, Griffin JL (2011) Systems level studies
of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance
spectroscopy. Chem Soc Rev 40:387
28. Theodoridis GA, Gika HG, Want EJ, Wilson ID (2012) Liquid chromatography–mass
spectrometry based global metabolite profiling: a review. Anal Chim Acta 711:7
29. Dettmer K, Aronov PA, Hammock BD (2007) Mass spectrometry-based metabolomics. Mass
Spectrom Rev 26:51
30. Lu W, Bennett BD, Rabinowitz JD (2008) Analytical strategies for LC-MS-based targeted
metabolomics. J Chromatogr, B: Anal Technol Biomed Life Sci 871:236
31. Gika HG, Theodoridis GA, Plumb RS, Wilson ID (2014) Current practice of liquid chromatography–mass spectrometry in metabolomics and metabonomics. J Pharm Biomed An
87:12
32. Chew WS, Torta F, Ji S, Choi H, Begum H, Sim X, Khoo CM, Khoo EYH, Ong W-Y, Van
Dam RM, Wenk MR, Tai ES, Herr DR (2019) Large-scale lipidomics identifies associations
between plasma sphingolipids and T2DM incidence. JCI Insight 5:e126925
33. Shah SH, Kraus WE, Newgard CB (2012) Metabolomic profiling for the identification of novel
biomarkers and mechanisms related to common cardiovascular diseases: form and function.
Circulation 126:1110
34. Markley JL, Bruschweiler R, Edison AS, Eghbalnia HR, Powers R, Raftery D, Wishart DS
(2017) The future of NMR-based metabolomics. Curr Opin Biotechnol 43:34
35. Larive CK, Barding G Jr, Dinges MM (2015) NMR spectroscopy for metabolomics and
metabolic profiling. Anal Chem 87:133
335
20. Lee SP, Lester R, Pyrek JS (1987) Vulpecholic acid (1α,3α,7α-trihydroxy-5β-cholan-24-oic
acid): a novel bile acid of a marsupial, Trichosurus vulpecula (Lesson). J Lipid Res 28:19
21. Roda A, Grigolo B, Minutello A, Pellicciari R, Natalini B (1990) Physicochemical and biological properties of natural and synthetic C-22 and C-23 hydroxylated bile acids. J Lipid Res
31:289
22. Hylemon PB, Melone PD, Franklund CV, Lund E, Björkhem I (1991) Mechanism of intestinal
7α-dehydroxylation of cholic acid: evidence that allo-deoxycholic acid is an inducible sideproduct. J Lipid Res 32:89
23. Craciun S, Balskus EP (2012) Microbial conversion of choline to trimethylamine requires a
glycyl radical enzyme. Proc Natl Acad Sci USA 109:21307
24. Wang Z, Roberts AB, Buffa JA, Levison BF, Zhu W, Org E, Gu X, Huang Y, ZamanianDaryoush M, Culley MK, DiDonato AJ, Fu X, Hazen JE, Krajcik D, DiDonato JA, Lusis AJ,
Hazen SL (2015) Non-lethal inhibition of gut microbial trimethylamine production for the
treatment of atherosclerosis. Cell 163:1585
25. Dorrestein PC, Mazmanian SK, Knight R (2014) From microbiomess to metabolomes to
function during host-microbial interactions. Immunity 40:824
26. Dettmer K, Aronov PA, Hammock BD (2007) Mass spectrometry-based metabolomics. Mass
Spectrom Rev 26:51
27. Dunn WB, Broadhurst DI, Atherton HJ, Goodacre R, Griffin JL (2011) Systems level studies
of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance
spectroscopy. Chem Soc Rev 40:387
28. Theodoridis GA, Gika HG, Want EJ, Wilson ID (2012) Liquid chromatography–mass
spectrometry based global metabolite profiling: a review. Anal Chim Acta 711:7
29. Dettmer K, Aronov PA, Hammock BD (2007) Mass spectrometry-based metabolomics. Mass
Spectrom Rev 26:51
30. Lu W, Bennett BD, Rabinowitz JD (2008) Analytical strategies for LC-MS-based targeted
metabolomics. J Chromatogr, B: Anal Technol Biomed Life Sci 871:236
31. Gika HG, Theodoridis GA, Plumb RS, Wilson ID (2014) Current practice of liquid chromatography–mass spectrometry in metabolomics and metabonomics. J Pharm Biomed An
87:12
32. Chew WS, Torta F, Ji S, Choi H, Begum H, Sim X, Khoo CM, Khoo EYH, Ong W-Y, Van
Dam RM, Wenk MR, Tai ES, Herr DR (2019) Large-scale lipidomics identifies associations
between plasma sphingolipids and T2DM incidence. JCI Insight 5:e126925
33. Shah SH, Kraus WE, Newgard CB (2012) Metabolomic profiling for the identification of novel
biomarkers and mechanisms related to common cardiovascular diseases: form and function.
Circulation 126:1110
34. Markley JL, Bruschweiler R, Edison AS, Eghbalnia HR, Powers R, Raftery D, Wishart DS
(2017) The future of NMR-based metabolomics. Curr Opin Biotechnol 43:34
35. Larive CK, Barding G Jr, Dinges MM (2015) NMR spectroscopy for metabolomics and
metabolic profiling. Anal Chem 87:133