170
N. N. Win and H. Morita
169 (panduratin E)
O
OH
O
168 (panduratin D)
O
OH
O
O
O
OH
O
O
170 (panduratin F)
171 (panduratin G)
O
O
O
OH
O
174 ((1'R,2'S,6'R)-2-hydroxyisopanduratin A)
R
1
R
2
172 (panduratin H)
R
1 = Phenyl, R
2 = COOMe
173 (panduratin I)
R
1 = COOMe, R
2 = Phenyl
O
OH
O
OH
Fig. 37 Structures of new cyclohexenyl chalcones 168–171 and 174 and cyclohexenyl derivatives
172 and 173 isolated from a chloroform extract of cultivated B. pandurata rhizomes in Myanmar
Myanmar. Among the isolated compounds, panduratins B1 (183) and B2 (184) were
obtained as diastereomers.
Anti-austerity assays revealed that a chloroform-soluble fraction of B. pandurata
rhizomes exhibited 100% preferential cytotoxicity (PC 100 ) against the human PANC1 pancreatic cancer cell line in a nutrient-deprived medium (NDM) at 10 μg/cm
3
[211]. Furthermore, in the same assay, the isolated compounds showed activity in
the order: 179, 186 (2.5 μM) > 185, 188 (8 μM)> 174, 175, 176, 180, 181 (16 μM)
> 178, 190, 193, 197, 198 (64 μM) > 168, 169, 171–173, 177, 183, 184, 187 (128
μM) > 170 (256 μM) > 182, 189, 191, 192, 194, 195, 196, 199 (> 256 μM). Among
the flavonoids, those compounds possessing a geranyl moiety showed more potent
activities (e.g, among the chalcones, 176 195, 196 and among the flavanones, 177,
N. N. Win and H. Morita
169 (panduratin E)
O
OH
O
168 (panduratin D)
O
OH
O
O
O
OH
O
O
170 (panduratin F)
171 (panduratin G)
O
O
O
OH
O
174 ((1'R,2'S,6'R)-2-hydroxyisopanduratin A)
R
1
R
2
172 (panduratin H)
R
1 = Phenyl, R
2 = COOMe
173 (panduratin I)
R
1 = COOMe, R
2 = Phenyl
O
OH
O
OH
Fig. 37 Structures of new cyclohexenyl chalcones 168–171 and 174 and cyclohexenyl derivatives
172 and 173 isolated from a chloroform extract of cultivated B. pandurata rhizomes in Myanmar
Myanmar. Among the isolated compounds, panduratins B1 (183) and B2 (184) were
obtained as diastereomers.
Anti-austerity assays revealed that a chloroform-soluble fraction of B. pandurata
rhizomes exhibited 100% preferential cytotoxicity (PC 100 ) against the human PANC1 pancreatic cancer cell line in a nutrient-deprived medium (NDM) at 10 μg/cm
3
[211]. Furthermore, in the same assay, the isolated compounds showed activity in
the order: 179, 186 (2.5 μM) > 185, 188 (8 μM)> 174, 175, 176, 180, 181 (16 μM)
> 178, 190, 193, 197, 198 (64 μM) > 168, 169, 171–173, 177, 183, 184, 187 (128
μM) > 170 (256 μM) > 182, 189, 191, 192, 194, 195, 196, 199 (> 256 μM). Among
the flavonoids, those compounds possessing a geranyl moiety showed more potent
activities (e.g, among the chalcones, 176 195, 196 and among the flavanones, 177,