Bioactive Compounds from Medicinal Plants in Myanmar
167
constituents have been reported from other Vitis species [185], there are few reports
concerning Vitis repens.
The phytochemical and pharmacological activities of the constituents of V. repens
from Myanmar were reported in 2004 [146], 2010 [186], and 2012 [187]. In 2004,
eight compounds, including bergenin (158) [188], isolariciresinol (159) [189], 1-[(3methylbutyryl)phloroglucinol]-β-d-glucopyranoside (160) [190], 4-O-methylgallic
acid (161) [191], protocatechuic acid (162) [192], gallic acid (105) [134], 2α,3β,23trihydroxyolean-12-en-28-oic-acid (120) [152], 4-O-galloylbergenin (163) (188),
and pallidol (164) [193] were isolated from the ethyl acetate and n-butanol extracts of
V. repens [146] (Fig. 34). In addition, according to the most potent antitrypanosomal
activity of the methanol extract of the dried root bark of V. repens, with an IC 50 value
of 8.6 ± 1.5 μg/cm
3 and the greatest selectivity index of 24.4 [186], bioactivityguided fractionation of an ethanolic extract of V. repens led to the isolation of three
compounds, comprising (E)-resveratrol (165) [194], 11-O-acetyl-bergenin (166)
[195], and stigmast-4-en-3-one (167) [196] in 2009 [187] (Fig. 35). The biological
160 (1-[(3-methylbutyryl)phloroglucinol]β -D-glucopyranoside)
OH
HO
O
O
O
H
OH
H
OH
H
H
HO H
COOH
HO
OR
1
R
2
105 (gallic acid) R
1 = H, R
2 = OH
161 (4-O-methylgallic acid) R
1 = Me, R
2 = OH
162 (protocatechuic acid) R
1 = R
2 = H
O
O
O
HO
O
HO
OH
O
O
OH
HO
OH
HO
163 (4-O-galloyl-bergenin )
HO
OH
HO
OH
OH
HO
164 (pallidol)
HO
O
O
OH
O
HO
O
OH
OH
158 (bergenin)
OH
OH
OH
O
HO
O
159 (isolariciresinol)
OH
Fig. 34 Structures of 158–164, 105, and 120 isolated from the ethyl acetate and n-butanol extracts
of the V. repens rhizomes